Diammonium Glycyrrhizinate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.114652
RPS12 ribosomal protein S12 0.0968647
RACK1 receptor for activated C kinase 1 0.0887635
MT2A metallothionein 2A 0.0838363
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0813625
YBX1 Y box binding protein 1 0.0776907
FTL ferritin, light polypeptide 0.0763353
RPL11 ribosomal protein L11 0.0733845
RPL23 ribosomal protein L23 0.0611234
B2M beta-2-microglobulin 0.0602676
RPL26 ribosomal protein L26 0.0571484
EEF2 eukaryotic translation elongation factor 2 0.0519907
PTMA prothymosin, alpha 0.05041
ZFP36 ZFP36 ring finger protein 0.0496696
RPLP0 ribosomal protein, large, P0 0.0473816
RPL12 ribosomal protein L12 0.046728
RPL3 ribosomal protein L3 0.044165
RPS17 ribosomal protein S17 0.0438704
RPL37A ribosomal protein L37a 0.0425663
RPL30 ribosomal protein L30 0.0422534
DDIT4 DNA-damage-inducible transcript 4 0.041177
RPL7 ribosomal protein L7 0.0408375
RPL4 ribosomal protein L4 0.0408023
RPS19 ribosomal protein S19 0.0387964
RPS4X ribosomal protein S4, X-linked 0.0357534
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0354049
RPS2 ribosomal protein S2 0.0350809
TPI1 triosephosphate isomerase 1 0.033442
LDHA lactate dehydrogenase A 0.0333125
RPL37 ribosomal protein L37 0.032725
UQCRB ubiquinol-cytochrome c reductase binding protein 0.031668
ANGPTL4 angiopoietin-like 4 0.0314043
NAP1L1 nucleosome assembly protein 1-like 1 0.0312154
TMSB10 thymosin beta 10 0.0310711
EGR1 early growth response 1 0.030815
RPL9 ribosomal protein L9 0.0305023
NACA nascent polypeptide-associated complex alpha subunit 0.0298148
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0295064
HLA-A major histocompatibility complex, class I, A 0.0292443
EIF1 eukaryotic translation initiation factor 1 0.0289999
GARS1 glycyl-tRNA synthetase 1 0.0285317
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282549
ADM adrenomedullin 0.0280719
SRRM2 serine/arginine repetitive matrix 2 0.0279764
RPLP1 ribosomal protein, large, P1 0.0276233
COX6C cytochrome c oxidase subunit VIc 0.0276064
IFITM3 interferon induced transmembrane protein 3 0.0274363
RPL31 ribosomal protein L31 0.0271216
LOC112694756 uncharaterized LOC112694756 0.0263244
SFTPA2 surfactant protein A2 0.0259977
RPS27 ribosomal protein S27 0.0255256
RPL21 ribosomal protein L21 0.0253588
ARRDC3 arrestin domain containing 3 0.0248901
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0246803
RPS15A ribosomal protein S15a 0.0245486
RPS8 ribosomal protein S8 0.0245012
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.024422
SERINC1 serine incorporator 1 0.0240817
RPL36 ribosomal protein L36 0.0239831
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0239161
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0238497
RPS14 ribosomal protein S14 0.0232544
KLF6 Kruppel-like factor 6 0.0226841
RPS5 ribosomal protein S5 0.0225419
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0217255
SET SET nuclear proto-oncogene 0.0216146
EEF1G eukaryotic translation elongation factor 1 gamma 0.0210503
NFE2L1 nuclear factor, erythroid 2-like 1 0.0207342
MYH9 myosin, heavy chain 9, non-muscle 0.0204488
SOX9 SRY (sex determining region Y)-box 9 0.0202651
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0190959
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0188898
TPM3 tropomyosin 3 0.0186367
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0186244
RPL18 ribosomal protein L18 0.0185524
GPX4 glutathione peroxidase 4 0.0182714
CSDE1 cold shock domain containing E1, RNA-binding 0.01824
MLEC malectin 0.0181417
JUN jun proto-oncogene 0.0179998
PDCD5 programmed cell death 5 0.0179532
MFGE8 milk fat globule-EGF factor 8 protein 0.0177841
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0176459
C15ORF48 chromosome 15 open reading frame 48 0.0175848
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0175716
RPL13A ribosomal protein L13a 0.0175512
MKI67 marker of proliferation Ki-67 0.0175428
SEPTIN7 septin 7 0.0174568
S100A6 S100 calcium binding protein A6 0.0173879
NDRG1 N-myc downstream regulated 1 0.0171454
LOC102724023 ES1 protein homolog, mitochondrial 0.016334
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0158822
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0158354
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0157274
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.015695
ECH1 enoyl CoA hydratase 1, peroxisomal 0.0153759
RPS7 ribosomal protein S7 0.015291
STC2 stanniocalcin 2 0.0151254
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0150922
CRABP2 cellular retinoic acid binding protein 2 0.0148319
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0147893

decreased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.207131
TRIO trio Rho guanine nucleotide exchange factor -0.145984
RPS16 ribosomal protein S16 -0.128747
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113295
VIM vimentin -0.112087
FNDC3B fibronectin type III domain containing 3B -0.107919
PTK2 protein tyrosine kinase 2 -0.101387
THSD4 thrombospondin, type I, domain containing 4 -0.0998266
VCL vinculin -0.0972407
SLC35F3 solute carrier family 35, member F3 -0.0954076
SBF2 SET binding factor 2 -0.0876769
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0868559
MACF1 microtubule-actin crosslinking factor 1 -0.0847537
DST dystonin -0.0804548
SDK1 sidekick cell adhesion molecule 1 -0.080038
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0790576
ACTN4 actinin, alpha 4 -0.0718668
HMGA2 high mobility group AT-hook 2 -0.0695379
TNS3 tensin 3 -0.0693098
JMJD1C jumonji domain containing 1C -0.0657222
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0647957
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0642138
AHNAK AHNAK nucleoprotein -0.0624445
TM4SF1 transmembrane 4 L six family member 1 -0.0623768
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0598055
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0568071
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0561058
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0557467
CARD18 caspase recruitment domain family, member 18 -0.0556907
AFAP1 actin filament associated protein 1 -0.0556518
ATG7 autophagy related 7 -0.0552219
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0548685
USP34 ubiquitin specific peptidase 34 -0.054834
ASPH aspartate beta-hydroxylase -0.0547023
MED13L mediator complex subunit 13-like -0.0524037
SEPTIN9 septin 9 -0.0516115
CD44 CD44 molecule (Indian blood group) -0.0513272
EFNA5 ephrin-A5 -0.0512622
ZFAND3 zinc finger, AN1-type domain 3 -0.050966
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0508147
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0505773
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0502035
EGFR epidermal growth factor receptor -0.0501136
EXT1 exostosin glycosyltransferase 1 -0.0500063
EHBP1 EH domain binding protein 1 -0.048762
NF1 neurofibromin 1 -0.0485314
ACTG1 actin gamma 1 -0.0473408
LPP LIM domain containing preferred translocation partner in lipoma -0.0470667
ZNF780B zinc finger protein 780B -0.0464044
RASAL2 RAS protein activator like 2 -0.0463681
NAV2 neuron navigator 2 -0.0463473
FBL fibrillarin -0.0462695
NUP98 nucleoporin 98kDa -0.0456893
MYOF myoferlin -0.0454096
SMAD3 SMAD family member 3 -0.0453743
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0450412
NPAS2 neuronal PAS domain protein 2 -0.0450389
EXOC4 exocyst complex component 4 -0.0450149
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0449201
ATXN1 ataxin 1 -0.0448882
RNF220 ring finger protein 220 -0.0445595
RAD51B RAD51 paralog B -0.0437619
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.04376
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0435901
CDK19 cyclin-dependent kinase 19 -0.043252
FAF1 Fas (TNFRSF6) associated factor 1 -0.0418911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0418471
NHSL1 NHS-like 1 -0.0417249
DIAPH2 diaphanous-related formin 2 -0.0416074
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0412636
IGF1R insulin-like growth factor 1 receptor -0.0411904
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0411194
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0407785
SMYD3 SET and MYND domain containing 3 -0.0406966
PDE10A phosphodiesterase 10A -0.0405763
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0401692
AKAP12 A kinase (PRKA) anchor protein 12 -0.0397934
UBASH3B ubiquitin associated and SH3 domain containing B -0.0388562
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0385125
INTS6 integrator complex subunit 6 -0.0383869
ARHGAP32 Rho GTPase activating protein 32 -0.0379352
WWTR1 WW domain containing transcription regulator 1 -0.0378786
TCF12 transcription factor 12 -0.0374248
MAML3 mastermind-like 3 (Drosophila) -0.0371842
PHF14 PHD finger protein 14 -0.0369486
ZNF207 zinc finger protein 207 -0.0369197
MYO10 myosin X -0.036607
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0362609
TPM1 tropomyosin 1 (alpha) -0.0349575
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0349196
FUS FUS RNA binding protein -0.0346816
CTSD cathepsin D -0.0346738
SAMD4B sterile alpha motif domain containing 4B -0.0345426
CDK13 cyclin-dependent kinase 13 -0.0343893
SPIDR scaffolding protein involved in DNA repair -0.0339535
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0332729
AKAP13 A kinase (PRKA) anchor protein 13 -0.0332621
ARHGAP26 Rho GTPase activating protein 26 -0.0332306
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0327924
RABGAP1L RAB GTPase activating protein 1-like -0.0326618