Diammonium Glycyrrhizinate_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.128162
EEF2 eukaryotic translation elongation factor 2 0.103337
FRMD6 FERM domain containing 6 0.0960891
RPL3 ribosomal protein L3 0.0944599
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0912979
RPS3 ribosomal protein S3 0.0896005
RPL23 ribosomal protein L23 0.0850815
RPL11 ribosomal protein L11 0.0757025
DLC1 DLC1 Rho GTPase activating protein 0.0747314
MCTP1 multiple C2 domains, transmembrane 1 0.0742155
TMSB10 thymosin beta 10 0.0690953
TRIO trio Rho guanine nucleotide exchange factor 0.0673264
RUNX1 runt-related transcription factor 1 0.065088
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0605029
ENO2 enolase 2 (gamma, neuronal) 0.0590684
STC1 stanniocalcin 1 0.0584904
SAMD4A sterile alpha motif domain containing 4A 0.0570997
CALD1 caldesmon 1 0.0570627
RPS4X ribosomal protein S4, X-linked 0.0569256
HMGA1 high mobility group AT-hook 1 0.0558741
TTR transthyretin 0.0536131
RPL8 ribosomal protein L8 0.0525279
MCL1 myeloid cell leukemia 1 0.0523002
GARS1 glycyl-tRNA synthetase 1 0.0510281
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0505916
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.050575
BIRC6 baculoviral IAP repeat containing 6 0.049384
RACK1 receptor for activated C kinase 1 0.0477079
INTS6 integrator complex subunit 6 0.0469667
KMT2E lysine (K)-specific methyltransferase 2E 0.0468719
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0464789
NDRG1 N-myc downstream regulated 1 0.0445576
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0438515
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0434059
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0431377
ATP13A3 ATPase type 13A3 0.0429631
ZFP36L1 ZFP36 ring finger protein-like 1 0.0423552
RPL12 ribosomal protein L12 0.0418203
SRRM2 serine/arginine repetitive matrix 2 0.0415805
KMT2C lysine (K)-specific methyltransferase 2C 0.0414435
LAMB3 laminin, beta 3 0.0413604
RPL7 ribosomal protein L7 0.0410571
RPL21 ribosomal protein L21 0.0403901
PBX3 pre-B-cell leukemia homeobox 3 0.039332
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.039157
PCBP2 poly(rC) binding protein 2 0.039138
HLA-A major histocompatibility complex, class I, A 0.0379147
RPL18 ribosomal protein L18 0.0373747
NUP58 nucleoporin 58 0.0370202
RPL26 ribosomal protein L26 0.0367137
DENND1A DENN/MADD domain containing 1A 0.0364622
SBF2 SET binding factor 2 0.035654
FTL ferritin, light polypeptide 0.0347741
SETD5 SET domain containing 5 0.0346923
SON SON DNA binding protein 0.0340964
DIAPH3 diaphanous-related formin 3 0.0329334
SRRM1 serine/arginine repetitive matrix 1 0.0322326
GLS2 glutaminase 2 (liver, mitochondrial) 0.0321458
RCOR1 REST corepressor 1 0.0321121
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0320557
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0318829
PDIA6 protein disulfide isomerase family A, member 6 0.0317779
BRD4 bromodomain containing 4 0.03172
RPS19 ribosomal protein S19 0.0316622
LPP LIM domain containing preferred translocation partner in lipoma 0.0315723
ZSWIM6 zinc finger, SWIM-type containing 6 0.0315562
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0313681
SFPQ splicing factor proline/glutamine-rich 0.0312454
USP9X ubiquitin specific peptidase 9, X-linked 0.0312058
FMNL2 formin-like 2 0.030822
RPS17 ribosomal protein S17 0.030615
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300002
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0296686
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0295407
APLP2 amyloid beta (A4) precursor-like protein 2 0.0294854
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0293205
SND1 staphylococcal nuclease and tudor domain containing 1 0.0291182
VMP1 vacuole membrane protein 1 0.029047
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.028971
FOXO3 forkhead box O3 0.0289639
COG5 component of oligomeric golgi complex 5 0.0289631
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0288072
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0286986
HMGA2 high mobility group AT-hook 2 0.0285953
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0283684
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0281885
EEF1G eukaryotic translation elongation factor 1 gamma 0.0281274
CALU calumenin 0.0278602
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0277656
LOC112694756 uncharaterized LOC112694756 0.0275265
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273003
CORO1C coronin, actin binding protein, 1C 0.0272791
CCNL1 cyclin L1 0.0271222
B2M beta-2-microglobulin 0.0269592
FNDC3B fibronectin type III domain containing 3B 0.0268645
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0266206
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0265974
POTEF POTE ankyrin domain family, member F 0.0265426
CLTC clathrin, heavy chain (Hc) 0.0262577
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0262071

decreased expression

Symbol Name Standardized Value
ZNF438 zinc finger protein 438 -0.0993545
ARHGAP22 Rho GTPase activating protein 22 -0.0955788
TPT1 tumor protein, translationally-controlled 1 -0.0826388
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0727689
IFI16 interferon, gamma-inducible protein 16 -0.0697252
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0600938
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0581723
ACTG1 actin gamma 1 -0.0561476
ZEB1 zinc finger E-box binding homeobox 1 -0.0550944
MTAP methylthioadenosine phosphorylase -0.0547032
KPNB1 karyopherin (importin) beta 1 -0.0545813
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0539109
C2CD2 C2 calcium-dependent domain containing 2 -0.0531337
ASPH aspartate beta-hydroxylase -0.0488537
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0484821
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0452839
RAD51B RAD51 paralog B -0.0444885
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.044372
IFI6 interferon, alpha-inducible protein 6 -0.0431589
NAV3 neuron navigator 3 -0.0426688
TM4SF1 transmembrane 4 L six family member 1 -0.041438
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0411368
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.039695
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0396048
RPL38 ribosomal protein L38 -0.0393099
TMEM156 transmembrane protein 156 -0.0384143
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0376713
EXT1 exostosin glycosyltransferase 1 -0.0373021
SP100 SP100 nuclear antigen -0.036301
RIGI RNA sensor RIG-I -0.0355273
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0350069
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0345666
FRMD4A FERM domain containing 4A -0.0343692
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0342045
ANTXR2 anthrax toxin receptor 2 -0.0340972
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0332583
RPS24 ribosomal protein S24 -0.0329556
ANXA2 annexin A2 -0.0329252
ANK2 ankyrin 2, neuronal -0.0325126
SPIDR scaffolding protein involved in DNA repair -0.0324962
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.031501
HMGB1 high mobility group box 1 -0.0302527
AHNAK AHNAK nucleoprotein -0.0296906
PHC2 polyhomeotic homolog 2 (Drosophila) -0.029282
WWOX WW domain containing oxidoreductase -0.0290984
MX2 MX dynamin-like GTPase 2 -0.0287203
AOPEP aminopeptidase O (putative) -0.0284678
CCDC91 coiled-coil domain containing 91 -0.0284098
RSL1D1 ribosomal L1 domain containing 1 -0.0282262
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0281028
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0279402
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0276181
TPM4 tropomyosin 4 -0.0275754
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0272493
SERBP1 SERPINE1 mRNA binding protein 1 -0.0271113
TCF12 transcription factor 12 -0.0269866
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0266148
ZC3H12B zinc finger CCCH-type containing 12B -0.0264749
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0259834
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0255191
AK1 adenylate kinase 1 -0.0251704
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.025067
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.024924
CUL1 cullin 1 -0.024847
NASP nuclear autoantigenic sperm protein (histone-binding) -0.024369
CUX1 cut-like homeobox 1 -0.024256
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0240575
SGMS2 sphingomyelin synthase 2 -0.0236865
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.0236759
FOXP1 forkhead box P1 -0.0236044
RPS2 ribosomal protein S2 -0.0234776
RAB3IP RAB3A interacting protein -0.0234589
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.023417
SAMD9 sterile alpha motif domain containing 9 -0.0233188
EFL1 elongation factor like GTPase 1 -0.0232765
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.023257
RPLP0 ribosomal protein, large, P0 -0.0231516
RPS15 ribosomal protein S15 -0.0227561
ZNFX1 zinc finger, NFX1-type containing 1 -0.022655
GSTO1 glutathione S-transferase omega 1 -0.0223799
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.022151
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0220466
RAD21 RAD21 homolog (S. pombe) -0.0220388
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.021968
CENPP centromere protein P -0.0218248
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0216447
RASAL2 RAS protein activator like 2 -0.021494
MAPK8 mitogen-activated protein kinase 8 -0.0214333
AGO2 argonaute RISC catalytic component 2 -0.0211738
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0211127
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0209587
RAI14 retinoic acid induced 14 -0.0207491
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0205181
ATAD2 ATPase family, AAA domain containing 2 -0.0205053
RPS29 ribosomal protein S29 -0.0204956
BZW1 basic leucine zipper and W2 domains 1 -0.0203654
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0201864
PTBP2 polypyrimidine tract binding protein 2 -0.0198883
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0197426
FCHSD2 FCH and double SH3 domains 2 -0.0196632