Diammonium Glycyrrhizinate_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SHP-77 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0787528
RPS3 ribosomal protein S3 0.059087
RPL11 ribosomal protein L11 0.0511902
ZSWIM6 zinc finger, SWIM-type containing 6 0.0505329
EGR1 early growth response 1 0.0424451
RPS12 ribosomal protein S12 0.0395972
RPL37A ribosomal protein L37a 0.039427
RPL37 ribosomal protein L37 0.0388103
MT2A metallothionein 2A 0.0385167
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0377297
MCTP1 multiple C2 domains, transmembrane 1 0.0357525
RPL23 ribosomal protein L23 0.0353097
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0345255
SETX senataxin 0.034504
TTC19 tetratricopeptide repeat domain 19 0.0309411
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0295193
RPL26 ribosomal protein L26 0.0278067
SNTG1 syntrophin, gamma 1 0.0276503
RPS19 ribosomal protein S19 0.0273483
RPL31 ribosomal protein L31 0.026939
FTL ferritin, light polypeptide 0.0262146
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0259632
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0259607
ATF6 activating transcription factor 6 0.0251085
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0249082
INTS6 integrator complex subunit 6 0.0248238
EPHA6 EPH receptor A6 0.0247463
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0242163
RPS17 ribosomal protein S17 0.0240379
VCL vinculin 0.023906
RPL9 ribosomal protein L9 0.0238022
HM13 histocompatibility (minor) 13 0.0237003
SCFD1 sec1 family domain containing 1 0.0236603
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0231374
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0231053
TMSB10 thymosin beta 10 0.0225899
MCL1 myeloid cell leukemia 1 0.0225667
TOP1 topoisomerase (DNA) I 0.0223187
UQCRB ubiquinol-cytochrome c reductase binding protein 0.021792
ESRRG estrogen-related receptor gamma 0.021767
ANKRD36C ankyrin repeat domain 36C 0.021583
CSNK1A1 casein kinase 1, alpha 1 0.0212802
EYA2 EYA transcriptional coactivator and phosphatase 2 0.020479
MRPS6 mitochondrial ribosomal protein S6 0.0204245
PTCHD4 patched domain containing 4 0.0203629
ADIPOR2 adiponectin receptor 2 0.0202448
STC1 stanniocalcin 1 0.0200881
RAB7A RAB7A, member RAS oncogene family 0.0199932
RORA RAR-related orphan receptor A 0.01998
RACK1 receptor for activated C kinase 1 0.0196469
NALF1 NALCN channel auxiliary factor 1 0.0194071
HOMER1 homer scaffolding protein 1 0.0192638
KLHL29 kelch-like family member 29 0.0191609
POTEF POTE ankyrin domain family, member F 0.0190233
EXT1 exostosin glycosyltransferase 1 0.0190109
CRY1 cryptochrome circadian clock 1 0.0185832
SPRED2 sprouty-related, EVH1 domain containing 2 0.0183365
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0181489
RPS8 ribosomal protein S8 0.0178565
RPLP0 ribosomal protein, large, P0 0.0177379
ATP5F1E ATP synthase F1 subunit epsilon 0.0175868
TPP2 tripeptidyl peptidase II 0.017122
UTP4 UTP4 small subunit processome component 0.0167151
ISG15 ISG15 ubiquitin-like modifier 0.0166733
COPA coatomer protein complex, subunit alpha 0.016327
B2M beta-2-microglobulin 0.0163211
GPATCH2L G patch domain containing 2-like 0.0161755
EFNA5 ephrin-A5 0.0159454
RPL12 ribosomal protein L12 0.0157634
BLZF1 basic leucine zipper nuclear factor 1 0.015698
HSPH1 heat shock 105kDa/110kDa protein 1 0.015523
ZFHX3 zinc finger homeobox 3 0.0153442
RPS14 ribosomal protein S14 0.015174
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0150651
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0149487
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.014734
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0140778
RPL27 ribosomal protein L27 0.013981
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0139338
KLHL18 kelch-like family member 18 0.0139077
TOPBP1 topoisomerase (DNA) II binding protein 1 0.0138733
FERMT2 fermitin family member 2 0.0138253
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0138123
RPL36AL ribosomal protein L36a-like 0.0134801
TPT1 tumor protein, translationally-controlled 1 0.0134058
SIK3 SIK family kinase 3 0.0133012
TMEM165 transmembrane protein 165 0.0132725
RBM4 RNA binding motif protein 4 0.0132449
PGM3 phosphoglucomutase 3 0.0132031
RPL30 ribosomal protein L30 0.0130623
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0130481
HSPE1 heat shock 10kDa protein 1 0.0130145
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0130041
SKP1 S-phase kinase-associated protein 1 0.0129263
ACBD3 acyl-CoA binding domain containing 3 0.012912
SH3RF1 SH3 domain containing ring finger 1 0.0128792
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0128363
PALLD palladin, cytoskeletal associated protein 0.0127452
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0127385
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0127006

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.262403
VGF VGF nerve growth factor inducible -0.184393
PEG10 paternally expressed 10 -0.0960572
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0908806
CENPF centromere protein F, 350/400kDa -0.0888991
CALCA calcitonin-related polypeptide alpha -0.0763344
ELL2 elongation factor, RNA polymerase II, 2 -0.0724596
ENO1 enolase 1, (alpha) -0.0666239
NCOR1 nuclear receptor corepressor 1 -0.062866
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0622836
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0577237
MKI67 marker of proliferation Ki-67 -0.0566374
PDE4B phosphodiesterase 4B, cAMP-specific -0.0544871
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0539147
RIT2 Ras-like without CAAX 2 -0.0537224
PTMA prothymosin, alpha -0.0520343
TMSB4X thymosin beta 4, X-linked -0.0512395
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0506056
AOPEP aminopeptidase O (putative) -0.0505427
IGFBP5 insulin-like growth factor binding protein 5 -0.0479714
TXNRD1 thioredoxin reductase 1 -0.0478756
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0471104
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0450748
SASH1 SAM and SH3 domain containing 1 -0.0436377
MYH9 myosin, heavy chain 9, non-muscle -0.0433423
SINHCAF SIN3-HDAC complex associated factor -0.0432818
NIPSNAP2 nipsnap homolog 2 -0.043257
PGK1 phosphoglycerate kinase 1 -0.0421405
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0415385
H1-0 H1.0 linker histone -0.0410414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0408417
SMOC1 SPARC related modular calcium binding 1 -0.0408183
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0406894
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0398914
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0373361
RAD21 RAD21 homolog (S. pombe) -0.0373044
TNRC6B trinucleotide repeat containing 6B -0.0368632
SYT4 synaptotagmin IV -0.0368444
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.036629
ZNF292 zinc finger protein 292 -0.036537
KDM3A lysine (K)-specific demethylase 3A -0.0350507
CHGB chromogranin B -0.03463
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0341873
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0335229
KIF26B kinesin family member 26B -0.0334855
PCM1 pericentriolar material 1 -0.0329979
CHD7 chromodomain helicase DNA binding protein 7 -0.0328559
PDE4D phosphodiesterase 4D, cAMP-specific -0.032676
SCG2 secretogranin II -0.0326082
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0325414
ADAR adenosine deaminase, RNA-specific -0.032457
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0318633
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0315955
TRIO trio Rho guanine nucleotide exchange factor -0.031468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0311362
ST18 suppression of tumorigenicity 18, zinc finger -0.031103
RPH3AL rabphilin 3A-like (without C2 domains) -0.0302417
NOVA1 neuro-oncological ventral antigen 1 -0.0302304
MACF1 microtubule-actin crosslinking factor 1 -0.0301021
TENT5A terminal nucleotidyltransferase 5A -0.0300839
WDFY3 WD repeat and FYVE domain containing 3 -0.0299346
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0298506
FCHSD2 FCH and double SH3 domains 2 -0.0289352
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -0.0287759
CPE carboxypeptidase E -0.0287083
RAB30 RAB30, member RAS oncogene family -0.0285846
SYT1 synaptotagmin I -0.0285745
RTN4 reticulon 4 -0.0281639
MPRIP myosin phosphatase Rho interacting protein -0.0277325
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0276516
OGA O-GlcNAcase -0.0275324
MYH10 myosin, heavy chain 10, non-muscle -0.0275187
KAT6A K(lysine) acetyltransferase 6A -0.0270358
CANX calnexin -0.0268155
SMYD3 SET and MYND domain containing 3 -0.0266023
MATR3 matrin 3 -0.0265534
DGKD diacylglycerol kinase, delta 130kDa -0.0264289
PHIP pleckstrin homology domain interacting protein -0.026396
FOXC1 forkhead box C1 -0.0261954
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0261799
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0260451
NPEPPS aminopeptidase puromycin sensitive -0.0260219
LCORL ligand dependent nuclear receptor corepressor-like -0.0259586
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0258291
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0257422
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0256452
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.025553
CADM1 cell adhesion molecule 1 -0.0254304
BCAS3 breast carcinoma amplified sequence 3 -0.0253566
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0251612
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0251599
PEX5L peroxisomal biogenesis factor 5-like -0.0251457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0250149
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0250008
GRAMD4 GRAM domain containing 4 -0.0248791
WDR45B WD repeat domain 45B -0.0247637
TBC1D5 TBC1 domain family, member 5 -0.0247118
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0244263
SMC1A structural maintenance of chromosomes 1A -0.0243793
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0243262