Diammonium Glycyrrhizinate_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.179609
LSAMP limbic system-associated membrane protein 0.155281
NRG3 neuregulin 3 0.152299
RPS3 ribosomal protein S3 0.134752
FN1 fibronectin 1 0.123934
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.123021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114302
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.112855
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.110743
RPL23 ribosomal protein L23 0.0998587
FMN1 formin 1 0.0994961
ANGPTL4 angiopoietin-like 4 0.0929358
VIM vimentin 0.0885132
PTMA prothymosin, alpha 0.0860371
B2M beta-2-microglobulin 0.0856077
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0813037
FRMD4A FERM domain containing 4A 0.0756414
PKM pyruvate kinase, muscle 0.0753965
AKAP12 A kinase (PRKA) anchor protein 12 0.0743655
RPL3 ribosomal protein L3 0.0718987
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0710256
DST dystonin 0.0706884
RPS12 ribosomal protein S12 0.0695001
FMNL2 formin-like 2 0.0690432
RACK1 receptor for activated C kinase 1 0.0642288
TPI1 triosephosphate isomerase 1 0.0639715
SEPTIN9 septin 9 0.0636149
FNDC3B fibronectin type III domain containing 3B 0.0630288
IFI6 interferon, alpha-inducible protein 6 0.0628294
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0622183
IGF1R insulin-like growth factor 1 receptor 0.0612247
SLC39A11 solute carrier family 39, member 11 0.0596401
NAP1L1 nucleosome assembly protein 1-like 1 0.0591817
TMSB10 thymosin beta 10 0.0590229
RAD51B RAD51 paralog B 0.0579953
ENO1 enolase 1, (alpha) 0.0573171
EEF2 eukaryotic translation elongation factor 2 0.0570091
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0558918
ZBTB20 zinc finger and BTB domain containing 20 0.0552007
FLNA filamin A, alpha 0.0540218
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0531595
BACE2 beta-site APP-cleaving enzyme 2 0.0528156
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0522836
RPL11 ribosomal protein L11 0.0519539
EHBP1 EH domain binding protein 1 0.0513323
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0511762
TRIO trio Rho guanine nucleotide exchange factor 0.0509035
TNNC1 troponin C type 1 (slow) 0.0499221
MSI2 musashi RNA-binding protein 2 0.0490874
RNF213 ring finger protein 213 0.0479003
RPS4X ribosomal protein S4, X-linked 0.047869
FLNB filamin B, beta 0.0475724
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0465377
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0460635
HDAC4 histone deacetylase 4 0.0450678
ASPH aspartate beta-hydroxylase 0.0444319
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0441599
LRMDA leucine rich melanocyte differentiation associated 0.0438353
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0435569
TPM3 tropomyosin 3 0.0433028
PGK1 phosphoglycerate kinase 1 0.0429046
KTN1 kinectin 1 (kinesin receptor) 0.0425504
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0425457
RPS17 ribosomal protein S17 0.0419757
PARP14 poly (ADP-ribose) polymerase family, member 14 0.04137
ZMIZ1 zinc finger, MIZ-type containing 1 0.0406317
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0403738
HLA-A major histocompatibility complex, class I, A 0.0399467
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0399401
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0394492
SFTPA2 surfactant protein A2 0.0393282
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0389815
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0387011
PRRC2C proline-rich coiled-coil 2C 0.0381562
RRBP1 ribosome binding protein 1 0.0380448
FHIT fragile histidine triad 0.0378134
MAML3 mastermind-like 3 (Drosophila) 0.0377896
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0375955
IFI44L interferon-induced protein 44-like 0.0375402
ENO2 enolase 2 (gamma, neuronal) 0.0369757
CTBP2 C-terminal binding protein 2 0.0369125
RPL37A ribosomal protein L37a 0.0357258
PLEC plectin 0.0356042
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0355787
LDHA lactate dehydrogenase A 0.0355273
AHNAK AHNAK nucleoprotein 0.0327961
NDRG1 N-myc downstream regulated 1 0.032687
CNKSR3 CNKSR family member 3 0.032579
PHF21A PHD finger protein 21A 0.0325453
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0321593
SVIL supervillin 0.031601
SP100 SP100 nuclear antigen 0.0313305
RPS19 ribosomal protein S19 0.0313298
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.031114
DIAPH2 diaphanous-related formin 2 0.0302933
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0299242
NRP2 neuropilin 2 0.0297333
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0296994
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.029578
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0293986

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.189891
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0994278
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0881269
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0468766
TXNRD1 thioredoxin reductase 1 -0.0429006
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0428904
CANX calnexin -0.0357357
ACTG1 actin gamma 1 -0.032524
ERBIN erbb2 interacting protein -0.0296828
GARS1 glycyl-tRNA synthetase 1 -0.0285197
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0236476
TSC22D2 TSC22 domain family, member 2 -0.021678
RPL38 ribosomal protein L38 -0.0205143
BIRC6 baculoviral IAP repeat containing 6 -0.0201028
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0198897
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0198151
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0195797
RB1CC1 RB1-inducible coiled-coil 1 -0.0194642
EXT1 exostosin glycosyltransferase 1 -0.0190973
EIF1 eukaryotic translation initiation factor 1 -0.0187453
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0186204
ACBD3 acyl-CoA binding domain containing 3 -0.0183278
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0178672
RTN4 reticulon 4 -0.0178147
KPNB1 karyopherin (importin) beta 1 -0.0175802
SREBF2 sterol regulatory element binding transcription factor 2 -0.0174413
TMEM263 transmembrane protein 263 -0.0169391
ELL2 elongation factor, RNA polymerase II, 2 -0.0162551
ZFAND6 zinc finger, AN1-type domain 6 -0.0161961
NAMPT nicotinamide phosphoribosyltransferase -0.0161447
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0160215
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.015804
MT1X metallothionein 1X -0.0156834
KLHDC10 kelch domain containing 10 -0.0155137
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0155009
CDC27 cell division cycle 27 -0.0153666
EPS8 epidermal growth factor receptor pathway substrate 8 -0.015317
NEK7 NIMA-related kinase 7 -0.015204
TMEM41B transmembrane protein 41B -0.0151673
TFPI2 tissue factor pathway inhibitor 2 -0.0148946
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0148251
ANXA5 annexin A5 -0.0148057
NF1 neurofibromin 1 -0.0146786
KDM3A lysine (K)-specific demethylase 3A -0.0146191
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0144996
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0144872
BRWD3 bromodomain and WD repeat domain containing 3 -0.0143626
IL6ST interleukin 6 signal transducer -0.0143258
FBXL2 F-box and leucine-rich repeat protein 2 -0.0141852
IARS1 isoleucyl-tRNA synthetase 1 -0.0140881
GOLGA4 golgin A4 -0.0140231
FNIP1 folliculin interacting protein 1 -0.0139618
COPB1 coatomer protein complex, subunit beta 1 -0.0138475
SPAG9 sperm associated antigen 9 -0.0137015
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0136854
TPST1 tyrosylprotein sulfotransferase 1 -0.013562
VEZT vezatin, adherens junctions transmembrane protein -0.0135334
COPA coatomer protein complex, subunit alpha -0.0135215
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0135172
BLZF1 basic leucine zipper nuclear factor 1 -0.0135163
WAC WW domain containing adaptor with coiled-coil -0.0135073
TFG TRK-fused gene -0.0134606
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.013288
VDAC1 voltage-dependent anion channel 1 -0.0132281
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0129871
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0129531
ZNF207 zinc finger protein 207 -0.0129388
TENT2 terminal nucleotidyltransferase 2 -0.012926
USP3 ubiquitin specific peptidase 3 -0.0129199
ANXA2 annexin A2 -0.0128577
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0128181
SNX9 sorting nexin 9 -0.0126883
TBC1D23 TBC1 domain family, member 23 -0.0126572
RASAL2 RAS protein activator like 2 -0.0126502
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0125832
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.012537
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0124145
PRKCI protein kinase C, iota -0.0123992
IPO7 importin 7 -0.0123455
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0123058
C6ORF62 chromosome 6 open reading frame 62 -0.01229
SEC24D SEC24 family member D -0.0122051
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0121879
PDIA3 protein disulfide isomerase family A, member 3 -0.0121471
WDR26 WD repeat domain 26 -0.0121383
BZW1 basic leucine zipper and W2 domains 1 -0.0120994
RAD21 RAD21 homolog (S. pombe) -0.0120747
TTC3 tetratricopeptide repeat domain 3 -0.0120471
PAIP2 poly(A) binding protein interacting protein 2 -0.0120246
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0120163
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0119944
NAP1L4 nucleosome assembly protein 1-like 4 -0.0119081
RPS23 ribosomal protein S23 -0.0118966
EMP1 epithelial membrane protein 1 -0.0118133
TP63 tumor protein p63 -0.0118111
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0118017
TUBB6 tubulin, beta 6 class V -0.0117744
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.011772
SEC23A Sec23 homolog A (S. cerevisiae) -0.0117701
CCSER2 coiled-coil serine-rich protein 2 -0.0117544