Diammonium Glycyrrhizinate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.123072
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.103077
TXNRD1 thioredoxin reductase 1 0.0691315
GOLGA4 golgin A4 0.0684713
ZNF292 zinc finger protein 292 0.0666221
LDHA lactate dehydrogenase A 0.0633137
LOC112694756 uncharaterized LOC112694756 0.0613611
EEF2 eukaryotic translation elongation factor 2 0.0612805
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0588455
PKM pyruvate kinase, muscle 0.0583547
TMSB4X thymosin beta 4, X-linked 0.0576527
S100A6 S100 calcium binding protein A6 0.0560464
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0551084
B2M beta-2-microglobulin 0.0521146
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0500693
PFN1 profilin 1 0.0493101
GARS1 glycyl-tRNA synthetase 1 0.0489415
EZR ezrin 0.0470239
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0460598
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.045939
RNF145 ring finger protein 145 0.0445514
NAMPT nicotinamide phosphoribosyltransferase 0.0442166
MT2A metallothionein 2A 0.0440062
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0427386
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0426307
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0421967
TXNIP thioredoxin interacting protein 0.0419079
ECT2 epithelial cell transforming 2 0.0413591
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382792
CDC73 cell division cycle 73 0.0377513
MATR3 matrin 3 0.0376397
RTN4 reticulon 4 0.0372851
RACK1 receptor for activated C kinase 1 0.037094
RPL12 ribosomal protein L12 0.036306
NUP58 nucleoporin 58 0.0359705
RPL3 ribosomal protein L3 0.0347899
CCNL1 cyclin L1 0.0345033
QKI QKI, KH domain containing, RNA binding 0.0330667
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0330664
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0329248
PGK1 phosphoglycerate kinase 1 0.0324092
KDM3A lysine (K)-specific demethylase 3A 0.0322036
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0320101
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0320017
RPL11 ribosomal protein L11 0.0318086
PNISR PNN-interacting serine/arginine-rich protein 0.0308925
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0307569
HMGA1 high mobility group AT-hook 1 0.0295895
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0294214
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0287529
DSTN destrin (actin depolymerizing factor) 0.0283273
KIF5B kinesin family member 5B 0.0281439
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0281114
RAB6A RAB6A, member RAS oncogene family 0.0279534
NCKAP1 NCK-associated protein 1 0.0276221
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0274812
ADAM9 ADAM metallopeptidase domain 9 0.027262
CSDE1 cold shock domain containing E1, RNA-binding 0.0271117
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0266695
TPI1 triosephosphate isomerase 1 0.0257528
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0253827
RPL4 ribosomal protein L4 0.0245488
TMEM41B transmembrane protein 41B 0.024449
PNRC1 proline-rich nuclear receptor coactivator 1 0.0244046
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0243772
RBM39 RNA binding motif protein 39 0.0243599
EIF4A2 eukaryotic translation initiation factor 4A2 0.0242016
RPL18 ribosomal protein L18 0.0241738
USP3 ubiquitin specific peptidase 3 0.023978
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238168
RPLP0 ribosomal protein, large, P0 0.0232234
TFG TRK-fused gene 0.0230432
BRWD1 bromodomain and WD repeat domain containing 1 0.0224298
FLNB filamin B, beta 0.0223571
DDIT4 DNA-damage-inducible transcript 4 0.0223431
GNAS GNAS complex locus 0.0223275
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0218274
RPS19 ribosomal protein S19 0.0217085
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.021682
FXR1 fragile X mental retardation, autosomal homolog 1 0.0215258
PTMA prothymosin, alpha 0.0212653
UBA6 ubiquitin-like modifier activating enzyme 6 0.0211474
TMSB10 thymosin beta 10 0.0210875
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0208298
ENO1 enolase 1, (alpha) 0.0207077
HMGB2 high mobility group box 2 0.0206079
ELOVL5 ELOVL fatty acid elongase 5 0.0203113
PTBP2 polypyrimidine tract binding protein 2 0.0202365
RPS2 ribosomal protein S2 0.0202155
SMC3 structural maintenance of chromosomes 3 0.0200748
U2SURP U2 snRNP-associated SURP domain containing 0.0200381
ZMYM2 zinc finger, MYM-type 2 0.0199435
RPS12 ribosomal protein S12 0.0198455
PDIA3 protein disulfide isomerase family A, member 3 0.0197668
EIF1 eukaryotic translation initiation factor 1 0.0197105
CASC3 cancer susceptibility candidate 3 0.0196923
RPL36 ribosomal protein L36 0.0196859
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0196481
LMAN1 lectin, mannose-binding, 1 0.0195691
NOP58 NOP58 ribonucleoprotein 0.0195549

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.125464
CPED1 cadherin-like and PC-esterase domain containing 1 -0.104757
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0995544
FOXP1 forkhead box P1 -0.0909443
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0908841
PDE4D phosphodiesterase 4D, cAMP-specific -0.0828482
EGFR epidermal growth factor receptor -0.0603981
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0473564
ZMYND8 zinc finger, MYND-type containing 8 -0.0461859
VCL vinculin -0.045543
NBEA neurobeachin -0.0417312
DLG1 discs, large homolog 1 (Drosophila) -0.0408697
INTS6 integrator complex subunit 6 -0.0402326
BMP10 bone morphogenetic protein 10 -0.0402006
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0401142
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0375941
TPT1 tumor protein, translationally-controlled 1 -0.0359363
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0355061
NPAS2 neuronal PAS domain protein 2 -0.0341852
TTC28 tetratricopeptide repeat domain 28 -0.0319314
SOX6 SRY (sex determining region Y)-box 6 -0.0317628
GLI3 GLI family zinc finger 3 -0.0304351
EFNA5 ephrin-A5 -0.0303904
TAS2R14 taste receptor, type 2, member 14 -0.0301688
FER1L6 fer-1-like family member 6 -0.0298274
PDE7B phosphodiesterase 7B -0.0292877
CUX1 cut-like homeobox 1 -0.0290038
ANKRD17 ankyrin repeat domain 17 -0.0288802
RPL31 ribosomal protein L31 -0.0286072
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0284949
NFE2L2 nuclear factor, erythroid 2-like 2 -0.02801
SEPTIN9 septin 9 -0.0277
GSE1 Gse1 coiled-coil protein -0.0271934
AEBP2 AE binding protein 2 -0.0270901
RPS23 ribosomal protein S23 -0.0267856
ASPH aspartate beta-hydroxylase -0.0265124
RPL35A ribosomal protein L35a -0.026274
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0262547
RPS25 ribosomal protein S25 -0.026251
MBNL1 muscleblind-like splicing regulator 1 -0.0259242
MYOF myoferlin -0.0253014
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0248283
PATJ PATJ crumbs cell polarity complex component -0.0247671
UNC13A unc-13 homolog A (C. elegans) -0.0245942
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0242256
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0236849
RPL38 ribosomal protein L38 -0.0235218
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0235012
MYO5C myosin VC -0.0234718
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0231167
RPS13 ribosomal protein S13 -0.0230402
FNDC3B fibronectin type III domain containing 3B -0.02285
GLI2 GLI family zinc finger 2 -0.0228274
RFC3 replication factor C (activator 1) 3, 38kDa -0.0220102
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0217907
ZNF438 zinc finger protein 438 -0.0214653
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0213651
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0213418
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0212236
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0208828
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.020676
BCOR BCL6 corepressor -0.0206533
PRUNE2 prune homolog 2 (Drosophila) -0.0205766
EBNA1BP2 EBNA1 binding protein 2 -0.0204019
TSC22D1 TSC22 domain family, member 1 -0.0203673
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0200351
DENND1A DENN/MADD domain containing 1A -0.0198792
NOP56 NOP56 ribonucleoprotein -0.0197325
FHIT fragile histidine triad -0.0195825
PSD3 pleckstrin and Sec7 domain containing 3 -0.019556
SMYD3 SET and MYND domain containing 3 -0.0194679
NAV2 neuron navigator 2 -0.0193654
RAB10 RAB10, member RAS oncogene family -0.0192814
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0192799
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0190638
ARMH4 armadillo like helical domain containing 4 -0.0189399
LOC102724023 ES1 protein homolog, mitochondrial -0.0188378
ITGA10 integrin, alpha 10 -0.0187646
TAOK1 TAO kinase 1 -0.0186989
PCNX4 pecanex 4 -0.0184473
RPS27A ribosomal protein S27a -0.0184188
RPS24 ribosomal protein S24 -0.0180349
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0179959
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0177948
TUBA1B tubulin, alpha 1b -0.0176051
KPNB1 karyopherin (importin) beta 1 -0.0175133
COMMD10 COMM domain containing 10 -0.0174999
CAMKMT calmodulin-lysine N-methyltransferase -0.0174627
PHF14 PHD finger protein 14 -0.0174387
DIAPH3 diaphanous-related formin 3 -0.017338
SFPQ splicing factor proline/glutamine-rich -0.0172984
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0172953
FNIP1 folliculin interacting protein 1 -0.0170773
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.017063
MKI67 marker of proliferation Ki-67 -0.0170001
ATXN2 ataxin 2 -0.016839
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0167877
ZMYND11 zinc finger, MYND-type containing 11 -0.016787
CCND1 cyclin D1 -0.0167332
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0166323