Diammonium Glycyrrhizinate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.307909
COL6A3 collagen, type VI, alpha 3 0.253482
TMSB10 thymosin beta 10 0.154942
STC1 stanniocalcin 1 0.102122
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0890371
NRXN3 neurexin 3 0.0848735
ENO1 enolase 1, (alpha) 0.0750313
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0684645
MYH9 myosin, heavy chain 9, non-muscle 0.0650374
AHNAK AHNAK nucleoprotein 0.0639392
MT1X metallothionein 1X 0.0625829
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.062427
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0602311
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0602284
AKAP12 A kinase (PRKA) anchor protein 12 0.0589516
TRIO trio Rho guanine nucleotide exchange factor 0.0586663
TPI1 triosephosphate isomerase 1 0.0584613
CALU calumenin 0.0579597
GLIS3 GLIS family zinc finger 3 0.0529697
ERRFI1 ERBB receptor feedback inhibitor 1 0.0520847
TIMP1 TIMP metallopeptidase inhibitor 1 0.0517134
ARRDC3 arrestin domain containing 3 0.0514127
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0506607
CALD1 caldesmon 1 0.0501598
ANKRD11 ankyrin repeat domain 11 0.0495523
PRELID2 PRELI domain containing 2 0.0483008
IGFBP7 insulin-like growth factor binding protein 7 0.0479643
COL5A1 collagen, type V, alpha 1 0.0461324
FRMD6 FERM domain containing 6 0.04529
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0440848
TGFBI transforming growth factor, beta-induced, 68kDa 0.0426741
DST dystonin 0.0422445
F3 coagulation factor III (thromboplastin, tissue factor) 0.0417204
TPM1 tropomyosin 1 (alpha) 0.0415938
B2M beta-2-microglobulin 0.0410731
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.04001
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0398679
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0398409
HMGA2 high mobility group AT-hook 2 0.039695
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0395297
JMJD1C jumonji domain containing 1C 0.0387248
HDLBP high density lipoprotein binding protein 0.0385625
LOXL2 lysyl oxidase-like 2 0.0375617
VIM vimentin 0.0375213
RTN4 reticulon 4 0.037454
CAVIN1 caveolae associated protein 1 0.0371813
IGFBP3 insulin-like growth factor binding protein 3 0.0371629
MACF1 microtubule-actin crosslinking factor 1 0.0361843
RACK1 receptor for activated C kinase 1 0.0359351
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354515
CAV1 caveolin 1, caveolae protein, 22kDa 0.0352906
NPC1 Niemann-Pick disease, type C1 0.0350434
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.035012
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0347738
LOC112694756 uncharaterized LOC112694756 0.0341925
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0340494
ANKRD12 ankyrin repeat domain 12 0.0338341
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0338334
LGALS1 lectin, galactoside-binding, soluble, 1 0.0336016
WNT5A wingless-type MMTV integration site family, member 5A 0.0335669
CDK6 cyclin-dependent kinase 6 0.0332988
RPL37A ribosomal protein L37a 0.0331006
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0329074
ATP13A3 ATPase type 13A3 0.032879
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0322684
ZNF292 zinc finger protein 292 0.0315918
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0315537
ABLIM3 actin binding LIM protein family, member 3 0.0314105
PDLIM5 PDZ and LIM domain 5 0.0312369
ARHGAP24 Rho GTPase activating protein 24 0.0309235
MKI67 marker of proliferation Ki-67 0.0305228
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0302228
ELL2 elongation factor, RNA polymerase II, 2 0.0299495
NIBAN2 niban apoptosis regulator 2 0.0295391
COL6A2 collagen, type VI, alpha 2 0.0295118
NAP1L1 nucleosome assembly protein 1-like 1 0.029454
GOLGB1 golgin B1 0.0294422
RPL3 ribosomal protein L3 0.0294319
RNF145 ring finger protein 145 0.0293583
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0292807
LAMB1 laminin, beta 1 0.0290123
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.028715
VEGFC vascular endothelial growth factor C 0.0286496
SOD2 superoxide dismutase 2, mitochondrial 0.0283996
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0283826
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.028382
ANXA2 annexin A2 0.0282918
DDIT4 DNA-damage-inducible transcript 4 0.0282183
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0281236
PTPRF protein tyrosine phosphatase, receptor type, F 0.0280736
SLMAP sarcolemma associated protein 0.0280717
MAP4 microtubule-associated protein 4 0.0280083
CKAP4 cytoskeleton-associated protein 4 0.0279863
CXCL8 chemokine (C-X-C motif) ligand 8 0.0279547
MYO9A myosin IXA 0.0278557
BACE2 beta-site APP-cleaving enzyme 2 0.027799
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0277928
RPL23 ribosomal protein L23 0.0277681
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0277203
CD44 CD44 molecule (Indian blood group) 0.0275901

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131628
COL1A1 collagen, type I, alpha 1 -0.072886
CADM1 cell adhesion molecule 1 -0.0580785
CANX calnexin -0.0504713
TRA2A transformer 2 alpha homolog (Drosophila) -0.0437409
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0423722
ACTG1 actin gamma 1 -0.0397646
DTNA dystrobrevin, alpha -0.0390948
FUS FUS RNA binding protein -0.0385357
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0379237
MED13L mediator complex subunit 13-like -0.0368258
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0342317
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0337313
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0335894
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0324858
TPT1 tumor protein, translationally-controlled 1 -0.0324669
BIRC6 baculoviral IAP repeat containing 6 -0.0324294
PUM2 pumilio RNA-binding family member 2 -0.0308786
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0304841
RPS11 ribosomal protein S11 -0.0300236
RPL35A ribosomal protein L35a -0.0295916
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0287977
RPL38 ribosomal protein L38 -0.0287399
PSD3 pleckstrin and Sec7 domain containing 3 -0.0283952
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283583
RPLP1 ribosomal protein, large, P1 -0.0283389
HDAC8 histone deacetylase 8 -0.0281613
KMT2E lysine (K)-specific methyltransferase 2E -0.0281455
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0273612
UBAC2 UBA domain containing 2 -0.0267754
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0265673
NOP58 NOP58 ribonucleoprotein -0.0265113
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026471
PTGES2 prostaglandin E synthase 2 -0.0263863
CCNI cyclin I -0.0263675
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.026306
FTL ferritin, light polypeptide -0.0261068
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0260714
VDAC1 voltage-dependent anion channel 1 -0.0259123
PALLD palladin, cytoskeletal associated protein -0.0258997
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0256718
MORF4L2 mortality factor 4 like 2 -0.0256689
KTN1 kinectin 1 (kinesin receptor) -0.0255194
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0255143
RASAL2 RAS protein activator like 2 -0.0253861
SREBF2 sterol regulatory element binding transcription factor 2 -0.0253418
ECE1 endothelin converting enzyme 1 -0.0251977
LMAN2 lectin, mannose-binding 2 -0.0251923
RAB7A RAB7A, member RAS oncogene family -0.0248811
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0245268
PTMA prothymosin, alpha -0.0244306
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0239909
ANKRD17 ankyrin repeat domain 17 -0.0238845
PDE4D phosphodiesterase 4D, cAMP-specific -0.0238582
FNDC3B fibronectin type III domain containing 3B -0.0237168
PAIP2 poly(A) binding protein interacting protein 2 -0.0237165
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.023614
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0235257
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0232192
CDK13 cyclin-dependent kinase 13 -0.0231998
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0231566
CDC27 cell division cycle 27 -0.0230615
BMERB1 bMERB domain containing 1 -0.0228313
RABGAP1 RAB GTPase activating protein 1 -0.0224942
WSB1 WD repeat and SOCS box containing 1 -0.0224451
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0224193
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0223377
GIGYF2 GRB10 interacting GYF protein 2 -0.0221906
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0221455
RREB1 ras responsive element binding protein 1 -0.0220873
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0219036
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.021606
RAB1A RAB1A, member RAS oncogene family -0.0215815
MAGT1 magnesium transporter 1 -0.0212587
SP100 SP100 nuclear antigen -0.0212338
GLG1 golgi glycoprotein 1 -0.0211974
SRPK2 SRSF protein kinase 2 -0.0209849
CARD16 caspase recruitment domain family, member 16 -0.0208365
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0205913
PDIA3 protein disulfide isomerase family A, member 3 -0.0205337
RNF11 ring finger protein 11 -0.020527
C2CD2 C2 calcium-dependent domain containing 2 -0.0205254
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -0.0204874
GPBP1 GC-rich promoter binding protein 1 -0.0204756
TRAK1 trafficking protein, kinesin binding 1 -0.0204174
EPB41 erythrocyte membrane protein band 4.1 -0.0204016
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0203805
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0202731
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0200995
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0200272
FHIT fragile histidine triad -0.0200151
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -0.0199887
NT5DC3 5'-nucleotidase domain containing 3 -0.0199246
CD99 CD99 molecule -0.0197635
TMEM184B transmembrane protein 184B -0.0197395
MCUB mitochondrial calcium uniporter dominant negative subunit beta -0.0196255
TUT4 terminal uridylyl transferase 4 -0.0195789
PTMS parathymosin -0.019538
UBAP1 ubiquitin associated protein 1 -0.0195132
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0194816