Diammonium Glycyrrhizinate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.101675
DPYD dihydropyrimidine dehydrogenase 0.0803449
MACF1 microtubule-actin crosslinking factor 1 0.0746045
DSCAM Down syndrome cell adhesion molecule 0.0734614
AKAP13 A kinase (PRKA) anchor protein 13 0.0733318
FMNL2 formin-like 2 0.0688129
LDHA lactate dehydrogenase A 0.0681675
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.061637
MBNL1 muscleblind-like splicing regulator 1 0.0610144
IGFBP3 insulin-like growth factor binding protein 3 0.0607872
TPI1 triosephosphate isomerase 1 0.0571161
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0489779
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0475471
GPC6 glypican 6 0.0473495
NAP1L1 nucleosome assembly protein 1-like 1 0.0467332
CD44 CD44 molecule (Indian blood group) 0.0459692
RPS12 ribosomal protein S12 0.0456835
NAMPT nicotinamide phosphoribosyltransferase 0.0456639
ENO1 enolase 1, (alpha) 0.0432402
BASP1 brain abundant, membrane attached signal protein 1 0.0406772
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0402226
RBM25 RNA binding motif protein 25 0.038002
GSK3B glycogen synthase kinase 3 beta 0.037723
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0376899
CLTC clathrin, heavy chain (Hc) 0.0365468
CXCL8 chemokine (C-X-C motif) ligand 8 0.0359411
LOC112694756 uncharaterized LOC112694756 0.0344264
CALR calreticulin 0.0342375
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0340157
ANKRD28 ankyrin repeat domain 28 0.0337935
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0337355
RSF1 remodeling and spacing factor 1 0.0334976
BBX bobby sox homolog (Drosophila) 0.0333527
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0328354
FBXL17 F-box and leucine-rich repeat protein 17 0.032522
PBX3 pre-B-cell leukemia homeobox 3 0.0306129
WSB1 WD repeat and SOCS box containing 1 0.0305911
DERA deoxyribose-phosphate aldolase (putative) 0.0304489
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0302592
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0299943
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0299718
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.029688
VIM vimentin 0.0296279
RSRC1 arginine/serine-rich coiled-coil 1 0.0295432
FLNB filamin B, beta 0.0294579
SBF2 SET binding factor 2 0.0290952
KIAA1958 KIAA1958 0.0290229
PHF21A PHD finger protein 21A 0.0286451
AKAP9 A kinase (PRKA) anchor protein 9 0.0284644
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0282955
PGK1 phosphoglycerate kinase 1 0.0281113
KIAA1328 KIAA1328 0.0280983
ASXL1 additional sex combs like transcriptional regulator 1 0.0274665
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0273622
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0269013
MBNL2 muscleblind-like splicing regulator 2 0.0267862
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0266921
TRIO trio Rho guanine nucleotide exchange factor 0.0264435
ADGRG6 adhesion G protein-coupled receptor G6 0.0264257
OSMR oncostatin M receptor 0.0261159
BTG1 B-cell translocation gene 1, anti-proliferative 0.026079
DTNA dystrobrevin, alpha 0.0259123
THOC2 THO complex 2 0.0258122
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0257965
MAP1B microtubule-associated protein 1B 0.0257328
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0256681
ENO2 enolase 2 (gamma, neuronal) 0.0256657
FXR1 fragile X mental retardation, autosomal homolog 1 0.0255317
RPL11 ribosomal protein L11 0.0254768
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0252489
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.0252231
RASAL2 RAS protein activator like 2 0.0251917
RECQL RecQ helicase-like 0.0249533
ACER3 alkaline ceramidase 3 0.0248924
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0247681
CARD16 caspase recruitment domain family, member 16 0.0246187
GRB10 growth factor receptor-bound protein 10 0.0245729
RORA RAR-related orphan receptor A 0.024367
AHNAK2 AHNAK nucleoprotein 2 0.0240371
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0238836
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0238621
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0238538
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0238008
RPL9 ribosomal protein L9 0.0237056
DARS1 aspartyl-tRNA synthetase 1 0.0234153
INSR insulin receptor 0.0234051
B2M beta-2-microglobulin 0.0232553
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0231097
CPNE3 copine III 0.0228747
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0227731
HILPDA hypoxia inducible lipid droplet-associated 0.0227566
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0227301
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0226865
CSNK1G1 casein kinase 1, gamma 1 0.0226672
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0224769
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0224432
NDRG1 N-myc downstream regulated 1 0.0223426
SKIC3 SKI3 subunit of superkiller complex 0.0223292
EP400 E1A binding protein p400 0.0223013
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222768

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0954347
TPT1 tumor protein, translationally-controlled 1 -0.0800932
RIGI RNA sensor RIG-I -0.0672291
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0549226
OASL 2'-5'-oligoadenylate synthetase-like -0.0536151
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0519472
RPLP1 ribosomal protein, large, P1 -0.0517279
GOLGA4 golgin A4 -0.0477863
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0452297
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0442481
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0436017
RPS8 ribosomal protein S8 -0.0425381
S100A10 S100 calcium binding protein A10 -0.0421357
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0419966
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0397389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0391142
GNAS GNAS complex locus -0.0374273
RAB1A RAB1A, member RAS oncogene family -0.0370765
SDC4 syndecan 4 -0.0366958
MCTP1 multiple C2 domains, transmembrane 1 -0.036152
NGLY1 N-glycanase 1 -0.0356225
POM121C POM121 transmembrane nucleoporin C -0.0354118
RPL35A ribosomal protein L35a -0.0341386
SNX14 sorting nexin 14 -0.0340019
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0333971
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0333204
IFIH1 interferon induced with helicase C domain 1 -0.032423
ZNF638 zinc finger protein 638 -0.0311841
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0310509
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0310294
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0308701
SRPK2 SRSF protein kinase 2 -0.0308587
TLK1 tousled-like kinase 1 -0.0299921
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0297708
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0295971
HOOK2 hook microtubule-tethering protein 2 -0.0286451
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0285817
USP53 ubiquitin specific peptidase 53 -0.0285376
LOC102724023 ES1 protein homolog, mitochondrial -0.0284651
GLRX glutaredoxin (thioltransferase) -0.0282253
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0280345
IL6ST interleukin 6 signal transducer -0.02794
SAFB scaffold attachment factor B -0.0278475
CHSY1 chondroitin sulfate synthase 1 -0.0275165
ISG15 ISG15 ubiquitin-like modifier -0.0275048
H3-3B H3.3 histone B -0.0274375
GOLGA3 golgin A3 -0.0271281
RCOR1 REST corepressor 1 -0.0270459
KTN1 kinectin 1 (kinesin receptor) -0.0269409
UBE2O ubiquitin-conjugating enzyme E2O -0.0268855
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0268718
NUMB numb homolog (Drosophila) -0.0266421
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0266134
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.026374
RPL31 ribosomal protein L31 -0.0263455
SP100 SP100 nuclear antigen -0.0260983
MED13 mediator complex subunit 13 -0.0260877
LMO7 LIM domain 7 -0.0260001
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0257222
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0253773
SH3KBP1 SH3-domain kinase binding protein 1 -0.0253554
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0253133
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0252767
IFITM3 interferon induced transmembrane protein 3 -0.0249492
DEK DEK proto-oncogene -0.0249037
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0249035
RPS28 ribosomal protein S28 -0.0248928
EP300 E1A binding protein p300 -0.0248264
BRD4 bromodomain containing 4 -0.0247198
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.02451
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0245021
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0241959
RPS6 ribosomal protein S6 -0.0240737
NUP58 nucleoporin 58 -0.0240316
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0240265
RPL34 ribosomal protein L34 -0.0239884
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0239761
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0239425
RPL27A ribosomal protein L27a -0.0238631
NF1 neurofibromin 1 -0.0236394
FTH1 ferritin, heavy polypeptide 1 -0.0235651
PRELID2 PRELI domain containing 2 -0.0233804
GDI2 GDP dissociation inhibitor 2 -0.0233778
COMMD1 copper metabolism (Murr1) domain containing 1 -0.0232824
CCDC138 coiled-coil domain containing 138 -0.0231137
SRSF9 serine/arginine-rich splicing factor 9 -0.0230236
USP3 ubiquitin specific peptidase 3 -0.0229501
SRP54 signal recognition particle 54kDa -0.0229353
NFE2L2 nuclear factor, erythroid 2-like 2 -0.02279
RPS15 ribosomal protein S15 -0.0226993
PRKCE protein kinase C, epsilon -0.0226877
FAM53C family with sequence similarity 53, member C -0.0225421
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0224897
MRTFA myocardin related transcription factor A -0.0222634
UBC ubiquitin C -0.0222516
CTBP2 C-terminal binding protein 2 -0.0222443
FAM3C family with sequence similarity 3, member C -0.0222182
PARD3 par-3 family cell polarity regulator -0.0221912
NIBAN2 niban apoptosis regulator 2 -0.0220832
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.022079