Diammonium Glycyrrhizinate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.107112
RACK1 receptor for activated C kinase 1 0.0903059
FTL ferritin, light polypeptide 0.0898546
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0819055
FTH1 ferritin, heavy polypeptide 1 0.0783886
NDRG1 N-myc downstream regulated 1 0.0711933
RPS12 ribosomal protein S12 0.0702597
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0661441
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0613224
RPL23 ribosomal protein L23 0.0595532
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0586932
LOC112694756 uncharaterized LOC112694756 0.050067
RPS3 ribosomal protein S3 0.046865
RPS27 ribosomal protein S27 0.0468589
TPI1 triosephosphate isomerase 1 0.0464789
B2M beta-2-microglobulin 0.0439007
AKAP12 A kinase (PRKA) anchor protein 12 0.0413569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0412605
TXNIP thioredoxin interacting protein 0.0389267
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0372446
NAMPT nicotinamide phosphoribosyltransferase 0.0370406
STC2 stanniocalcin 2 0.0362947
RPS19 ribosomal protein S19 0.035226
RPL3 ribosomal protein L3 0.0351828
RPL26 ribosomal protein L26 0.0344975
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034275
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0342312
RPL11 ribosomal protein L11 0.0337296
TPM3 tropomyosin 3 0.0335817
PLIN2 perilipin 2 0.0331091
RPL31 ribosomal protein L31 0.0330216
AHR aryl hydrocarbon receptor 0.0327926
ENO2 enolase 2 (gamma, neuronal) 0.0322177
ACBD3 acyl-CoA binding domain containing 3 0.0319261
ARRDC3 arrestin domain containing 3 0.0310788
RPL36 ribosomal protein L36 0.0309109
MRPS6 mitochondrial ribosomal protein S6 0.0293334
CSDE1 cold shock domain containing E1, RNA-binding 0.02902
CD46 CD46 molecule, complement regulatory protein 0.0275481
RPL30 ribosomal protein L30 0.0271633
RPL18 ribosomal protein L18 0.0271091
GLUL glutamate-ammonia ligase 0.0262817
RPL37 ribosomal protein L37 0.0257385
SRRM2 serine/arginine repetitive matrix 2 0.0256821
CALR calreticulin 0.0252091
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0250034
EEF2 eukaryotic translation elongation factor 2 0.0248085
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0243396
BASP1 brain abundant, membrane attached signal protein 1 0.0238166
ZCCHC7 zinc finger, CCHC domain containing 7 0.0228514
PGK1 phosphoglycerate kinase 1 0.0227817
RPL7 ribosomal protein L7 0.0227184
ANGPTL4 angiopoietin-like 4 0.0223853
SON SON DNA binding protein 0.0222697
CANX calnexin 0.0222002
TXNRD1 thioredoxin reductase 1 0.0221424
MLEC malectin 0.0220993
HMGB3 high mobility group box 3 0.0217133
RPL12 ribosomal protein L12 0.0215899
RPL37A ribosomal protein L37a 0.0213011
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0210586
SOX9 SRY (sex determining region Y)-box 9 0.0207525
CD109 CD109 molecule 0.0205712
KMT2C lysine (K)-specific methyltransferase 2C 0.0204735
UBXN4 UBX domain protein 4 0.0201639
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0200369
SLTM SAFB-like, transcription modulator 0.0196728
SRRM1 serine/arginine repetitive matrix 1 0.0194839
SERINC1 serine incorporator 1 0.0194283
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0191564
FAM13A family with sequence similarity 13, member A 0.0190267
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0187473
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0182311
YBX1 Y box binding protein 1 0.01812
TTC3 tetratricopeptide repeat domain 3 0.0181091
CFB complement factor B 0.0178917
STC1 stanniocalcin 1 0.0178079
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0176416
SEC62 SEC62 homolog (S. cerevisiae) 0.0174614
TMSB10 thymosin beta 10 0.0174538
HLA-A major histocompatibility complex, class I, A 0.0172992
PDIA6 protein disulfide isomerase family A, member 6 0.017107
RPL13A ribosomal protein L13a 0.0170643
RPS17 ribosomal protein S17 0.0169861
GOLGA3 golgin A3 0.0167503
PRRC2C proline-rich coiled-coil 2C 0.0166797
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016674
IDS iduronate 2-sulfatase 0.016664
DDIT4 DNA-damage-inducible transcript 4 0.0166511
FBXO32 F-box protein 32 0.0165872
RPL21 ribosomal protein L21 0.0164644
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.016298
EREG epiregulin 0.0162759
AKAP9 A kinase (PRKA) anchor protein 9 0.0162734
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0162229
MCFD2 multiple coagulation factor deficiency 2 0.0161257
VIRMA vir like m6A methyltransferase associated 0.0160231
CD44 CD44 molecule (Indian blood group) 0.0159066
LDHA lactate dehydrogenase A 0.0158438
LIFR leukemia inhibitory factor receptor alpha 0.0157084

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.224397
ASPH aspartate beta-hydroxylase -0.170336
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168075
VCL vinculin -0.144874
EXT1 exostosin glycosyltransferase 1 -0.103522
HMGA2 high mobility group AT-hook 2 -0.101491
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0888394
ZSWIM6 zinc finger, SWIM-type containing 6 -0.085649
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0849059
FNDC3B fibronectin type III domain containing 3B -0.083492
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0823994
ACTG1 actin gamma 1 -0.0771288
AEBP2 AE binding protein 2 -0.0686147
INTS6 integrator complex subunit 6 -0.0676322
TPT1 tumor protein, translationally-controlled 1 -0.0654429
PTMA prothymosin, alpha -0.0650969
GRB10 growth factor receptor-bound protein 10 -0.0623057
PTK2 protein tyrosine kinase 2 -0.0601779
S100A6 S100 calcium binding protein A6 -0.057899
TAS2R14 taste receptor, type 2, member 14 -0.0574924
HLA-B major histocompatibility complex, class I, B -0.0550088
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.053782
S100A10 S100 calcium binding protein A10 -0.0537572
PALLD palladin, cytoskeletal associated protein -0.0508918
FN1 fibronectin 1 -0.048153
LRMDA leucine rich melanocyte differentiation associated -0.0471728
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.045512
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0446385
CADM1 cell adhesion molecule 1 -0.044475
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0437958
ITGA1 integrin, alpha 1 -0.0433142
EGR1 early growth response 1 -0.0428499
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0426522
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0419609
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0413895
PDLIM5 PDZ and LIM domain 5 -0.0400999
MAML2 mastermind-like 2 (Drosophila) -0.0400716
RAB7A RAB7A, member RAS oncogene family -0.0400595
TRIO trio Rho guanine nucleotide exchange factor -0.0393092
NCOA7 nuclear receptor coactivator 7 -0.0379548
RUNX1 runt-related transcription factor 1 -0.0379002
RPL38 ribosomal protein L38 -0.0377347
LOC102724023 ES1 protein homolog, mitochondrial -0.037169
RAB10 RAB10, member RAS oncogene family -0.0367503
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.036636
RPS24 ribosomal protein S24 -0.0366345
SYT1 synaptotagmin I -0.0366324
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0363633
RPS21 ribosomal protein S21 -0.0360135
SQSTM1 sequestosome 1 -0.0356868
NXN nucleoredoxin -0.0356542
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0352921
SOX5 SRY (sex determining region Y)-box 5 -0.0351288
KLHL5 kelch-like family member 5 -0.0349405
IER3 immediate early response 3 -0.0346879
RASAL2 RAS protein activator like 2 -0.0343517
PRKCA protein kinase C, alpha -0.0338113
RIGI RNA sensor RIG-I -0.0337308
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0336216
NTN4 netrin 4 -0.033415
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0330616
FUS FUS RNA binding protein -0.0326484
SPAG9 sperm associated antigen 9 -0.0322712
RNF213 ring finger protein 213 -0.0317059
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317024
LRRC23 leucine rich repeat containing 23 -0.0311698
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0309096
GPC6 glypican 6 -0.030889
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0307165
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0304109
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0303018
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0302451
RCOR1 REST corepressor 1 -0.0302359
LTBP1 latent transforming growth factor beta binding protein 1 -0.0300054
NPAS2 neuronal PAS domain protein 2 -0.0299788
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0298786
EXOC4 exocyst complex component 4 -0.0298729
TM4SF1 transmembrane 4 L six family member 1 -0.0296058
ATXN1 ataxin 1 -0.029581
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0294901
IFI27 interferon, alpha-inducible protein 27 -0.0294755
TMSB4X thymosin beta 4, X-linked -0.0293285
BICD1 bicaudal D homolog 1 (Drosophila) -0.0284571
FHIT fragile histidine triad -0.0284372
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0283514
SFRP1 secreted frizzled-related protein 1 -0.0283428
FBXO11 F-box protein 11 -0.0281868
IFIH1 interferon induced with helicase C domain 1 -0.0280727
MAP1B microtubule-associated protein 1B -0.0279407
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0278582
RAD51B RAD51 paralog B -0.0278445
LY6E lymphocyte antigen 6 complex, locus E -0.027696
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0275978
NAV1 neuron navigator 1 -0.0272671
PARD3 par-3 family cell polarity regulator -0.0272226
IL6ST interleukin 6 signal transducer -0.0271923
NRIP1 nuclear receptor interacting protein 1 -0.0271236
TMEM156 transmembrane protein 156 -0.0270931
ATF6 activating transcription factor 6 -0.0269741
PSD3 pleckstrin and Sec7 domain containing 3 -0.0267178