Diammonium Glycyrrhizinate_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.163284
RPL23 ribosomal protein L23 0.0928401
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0902083
RPS3 ribosomal protein S3 0.0875793
RPS12 ribosomal protein S12 0.0791691
VCL vinculin 0.0763102
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0753255
INTS6 integrator complex subunit 6 0.0740939
NCEH1 neutral cholesterol ester hydrolase 1 0.0698944
RACK1 receptor for activated C kinase 1 0.0692615
ZSWIM6 zinc finger, SWIM-type containing 6 0.0652611
EPCAM epithelial cell adhesion molecule 0.0649008
RPL26 ribosomal protein L26 0.0641217
RPL12 ribosomal protein L12 0.0592443
RPL37A ribosomal protein L37a 0.0560803
IFRD1 interferon-related developmental regulator 1 0.0554796
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.054255
RPL11 ribosomal protein L11 0.0522847
RPS17 ribosomal protein S17 0.0520179
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0512837
AHNAK AHNAK nucleoprotein 0.048404
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0483943
RPL31 ribosomal protein L31 0.0479936
SHB Src homology 2 domain containing adaptor protein B 0.0473057
CEMIP2 cell migration inducing hyaluronidase 2 0.0454628
RPL30 ribosomal protein L30 0.0454571
TMSB10 thymosin beta 10 0.0448962
HSPA8 heat shock 70kDa protein 8 0.0439182
RPS4X ribosomal protein S4, X-linked 0.0430413
MYO1E myosin IE 0.0422429
RPL13A ribosomal protein L13a 0.041804
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0414171
APLP2 amyloid beta (A4) precursor-like protein 2 0.0412212
LOC112694756 uncharaterized LOC112694756 0.0405802
RPL3 ribosomal protein L3 0.0395318
RPL18 ribosomal protein L18 0.0391861
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0388432
CSNK1A1 casein kinase 1, alpha 1 0.0387887
EEF2 eukaryotic translation elongation factor 2 0.03878
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0384511
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0368809
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0361266
GNAS GNAS complex locus 0.0355152
RPS19 ribosomal protein S19 0.0345045
NABP1 nucleic acid binding protein 1 0.0342114
RPL4 ribosomal protein L4 0.0340255
EXT1 exostosin glycosyltransferase 1 0.0340198
SMAD3 SMAD family member 3 0.0334091
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0333744
ZNF217 zinc finger protein 217 0.0332037
RPL36 ribosomal protein L36 0.0330526
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0329121
RPL37 ribosomal protein L37 0.0321689
SOX9 SRY (sex determining region Y)-box 9 0.0316751
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.031497
RPS15A ribosomal protein S15a 0.0310132
SAMD4A sterile alpha motif domain containing 4A 0.0307303
RAB7A RAB7A, member RAS oncogene family 0.030624
TUFT1 tuftelin 1 0.030414
TPI1 triosephosphate isomerase 1 0.0303977
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0300241
FAM107B family with sequence similarity 107, member B 0.0299846
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0294323
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0290718
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0285517
BZW2 basic leucine zipper and W2 domains 2 0.0283878
NDRG1 N-myc downstream regulated 1 0.0281526
HDLBP high density lipoprotein binding protein 0.028083
RPL27 ribosomal protein L27 0.0278923
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0274794
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0271189
EGR1 early growth response 1 0.0270984
PTPRK protein tyrosine phosphatase, receptor type, K 0.0269891
EGFR epidermal growth factor receptor 0.0266343
CTBP2 C-terminal binding protein 2 0.0265473
ZFP36L2 ZFP36 ring finger protein-like 2 0.0262009
GOLGB1 golgin B1 0.0261242
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259407
PGK1 phosphoglycerate kinase 1 0.0256818
LDHA lactate dehydrogenase A 0.0253603
PMM2 phosphomannomutase 2 0.024551
TJP1 tight junction protein 1 0.0243296
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0242314
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0237991
KLF5 Kruppel-like factor 5 (intestinal) 0.0237693
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0237138
B2M beta-2-microglobulin 0.0235379
ANXA2 annexin A2 0.0235149
TRIB1 tribbles pseudokinase 1 0.0233747
FAT1 FAT atypical cadherin 1 0.0233233
CALU calumenin 0.0232267
RPL7 ribosomal protein L7 0.0229284
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0228467
KLF6 Kruppel-like factor 6 0.0227933
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.022471
CEMIP cell migration inducing protein, hyaluronan binding 0.0223392
RPS27A ribosomal protein S27a 0.0223257
PDLIM5 PDZ and LIM domain 5 0.022233
GSTP1 glutathione S-transferase pi 1 0.0220333
COX6C cytochrome c oxidase subunit VIc 0.0219841

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.169097
FTH1 ferritin, heavy polypeptide 1 -0.0946102
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0854017
MACC1 metastasis associated in colon cancer 1 -0.0790697
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0758806
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0716908
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0707933
SDK1 sidekick cell adhesion molecule 1 -0.0685812
XPO1 exportin 1 -0.0613656
KMT2E lysine (K)-specific methyltransferase 2E -0.059179
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0535691
ZMYND8 zinc finger, MYND-type containing 8 -0.0533881
PERP PERP, TP53 apoptosis effector -0.0521964
SNX9 sorting nexin 9 -0.0519549
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0513719
BCL2L1 BCL2-like 1 -0.0510613
ZNRF3 zinc and ring finger 3 -0.0504692
RPS21 ribosomal protein S21 -0.0494439
ITCH itchy E3 ubiquitin protein ligase -0.0489596
MAML2 mastermind-like 2 (Drosophila) -0.0486134
SRPK2 SRSF protein kinase 2 -0.0481327
CCNL1 cyclin L1 -0.0479279
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0478923
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0473852
RPLP2 ribosomal protein, large, P2 -0.0467061
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0456332
USP3 ubiquitin specific peptidase 3 -0.0433043
RPS6 ribosomal protein S6 -0.042142
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0420428
ZNF292 zinc finger protein 292 -0.0407424
RBM39 RNA binding motif protein 39 -0.03991
KDM7A lysine (K)-specific demethylase 7A -0.0397297
ZFAND3 zinc finger, AN1-type domain 3 -0.0395372
MED13L mediator complex subunit 13-like -0.0393444
ADNP activity-dependent neuroprotector homeobox -0.0390219
ZNF148 zinc finger protein 148 -0.0387913
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0384442
FAM3C family with sequence similarity 3, member C -0.0381528
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0381126
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0380104
NPEPPS aminopeptidase puromycin sensitive -0.0379963
IPO7 importin 7 -0.0374057
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0372483
JMJD1C jumonji domain containing 1C -0.0371059
UBE2H ubiquitin-conjugating enzyme E2H -0.0366122
PLAUR plasminogen activator, urokinase receptor -0.0365594
DLG1 discs, large homolog 1 (Drosophila) -0.0364871
ESYT2 extended synaptotagmin-like protein 2 -0.0363445
RTN4 reticulon 4 -0.0363268
MATR3 matrin 3 -0.0360731
SBF2 SET binding factor 2 -0.0345511
SETD5 SET domain containing 5 -0.0344318
PDIA3 protein disulfide isomerase family A, member 3 -0.0343661
TMEM41B transmembrane protein 41B -0.0343646
GOLGA4 golgin A4 -0.0343608
ANKRD28 ankyrin repeat domain 28 -0.033871
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0337307
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0335496
THOC2 THO complex 2 -0.033401
ADAM17 ADAM metallopeptidase domain 17 -0.0330181
SEPTIN7 septin 7 -0.03275
GPSM2 G-protein signaling modulator 2 -0.0326294
FOSL1 FOS-like antigen 1 -0.0324728
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0324579
KPNB1 karyopherin (importin) beta 1 -0.0324133
PTBP3 polypyrimidine tract binding protein 3 -0.0321926
CCND1 cyclin D1 -0.032003
RBM25 RNA binding motif protein 25 -0.0310644
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0309772
LOC102724023 ES1 protein homolog, mitochondrial -0.0307054
MAP4 microtubule-associated protein 4 -0.0306094
OXR1 oxidation resistance 1 -0.0299768
RPL28 ribosomal protein L28 -0.0296532
LMTK2 lemur tyrosine kinase 2 -0.0295505
SCAF11 SR-related CTD-associated factor 11 -0.0294474
RAB6A RAB6A, member RAS oncogene family -0.0294323
PATJ PATJ crumbs cell polarity complex component -0.0292572
PTK2 protein tyrosine kinase 2 -0.0290876
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0289483
YAP1 Yes-associated protein 1 -0.0286013
CDCP1 CUB domain containing protein 1 -0.02854
GARS1 glycyl-tRNA synthetase 1 -0.0284506
KRT8 keratin 8, type II -0.0284283
PCBP2 poly(rC) binding protein 2 -0.0282969
KMT2C lysine (K)-specific methyltransferase 2C -0.0282738
ZNF207 zinc finger protein 207 -0.0282414
TXNIP thioredoxin interacting protein -0.028205
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0276833
CBX3 chromobox homolog 3 -0.0276316
FXR1 fragile X mental retardation, autosomal homolog 1 -0.02744
CUX1 cut-like homeobox 1 -0.02735
ATP5F1B ATP synthase F1 subunit beta -0.0272726
OSBPL10 oxysterol binding protein-like 10 -0.0271635
DEK DEK proto-oncogene -0.0269145
RNF149 ring finger protein 149 -0.026554
RBM6 RNA binding motif protein 6 -0.0265526
KTN1 kinectin 1 (kinesin receptor) -0.0265141
RPL36A ribosomal protein L36a -0.0264778
RREB1 ras responsive element binding protein 1 -0.0263085
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0262948