Diammonium Glycyrrhizinate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.102578
RPS3 ribosomal protein S3 0.101788
RPS12 ribosomal protein S12 0.0938986
AREG amphiregulin 0.0910877
RACK1 receptor for activated C kinase 1 0.0898302
RPL3 ribosomal protein L3 0.0842404
EEF2 eukaryotic translation elongation factor 2 0.0837468
RPL26 ribosomal protein L26 0.0779576
RPL23 ribosomal protein L23 0.0738644
TMSB10 thymosin beta 10 0.0734207
RPS19 ribosomal protein S19 0.0683568
ANXA1 annexin A1 0.0654605
MT2A metallothionein 2A 0.0609379
LMO7 LIM domain 7 0.0602149
RPS17 ribosomal protein S17 0.0564126
RPL12 ribosomal protein L12 0.0559328
TOP1 topoisomerase (DNA) I 0.0553921
PDE4B phosphodiesterase 4B, cAMP-specific 0.0545835
RPL11 ribosomal protein L11 0.0538276
RPL37A ribosomal protein L37a 0.0529627
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0500881
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0494317
RPS4X ribosomal protein S4, X-linked 0.048965
RPL4 ribosomal protein L4 0.04724
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0458533
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0444609
LOC112694756 uncharaterized LOC112694756 0.0439139
RPL36 ribosomal protein L36 0.0433559
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.041044
GOLGA4 golgin A4 0.0406375
TXNRD1 thioredoxin reductase 1 0.0396943
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.039511
RPL9 ribosomal protein L9 0.0390206
FAT1 FAT atypical cadherin 1 0.0389121
RNF43 ring finger protein 43 0.0379814
EREG epiregulin 0.0374915
RPS8 ribosomal protein S8 0.037334
SLTM SAFB-like, transcription modulator 0.0371676
RPL7 ribosomal protein L7 0.0365715
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0341224
LAMC2 laminin, gamma 2 0.0336218
LDHA lactate dehydrogenase A 0.0330284
EEF1G eukaryotic translation elongation factor 1 gamma 0.0329871
OXR1 oxidation resistance 1 0.032374
NAP1L1 nucleosome assembly protein 1-like 1 0.0322641
ITPRID2 ITPR interacting domain containing 2 0.0316514
RPS27 ribosomal protein S27 0.0316395
NCEH1 neutral cholesterol ester hydrolase 1 0.0314187
KTN1 kinectin 1 (kinesin receptor) 0.0302402
RPL37 ribosomal protein L37 0.029389
SRRM2 serine/arginine repetitive matrix 2 0.0288875
EZR ezrin 0.0286972
RPL21 ribosomal protein L21 0.0282351
KMT2C lysine (K)-specific methyltransferase 2C 0.0281414
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0280273
RPL30 ribosomal protein L30 0.0280015
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0277454
RPL31 ribosomal protein L31 0.0275303
NACA nascent polypeptide-associated complex alpha subunit 0.0272349
NDRG1 N-myc downstream regulated 1 0.0271742
RPS2 ribosomal protein S2 0.0269621
PLAUR plasminogen activator, urokinase receptor 0.0263349
YBX1 Y box binding protein 1 0.0261597
RPL18 ribosomal protein L18 0.0258283
KLF6 Kruppel-like factor 6 0.0256979
RPL35 ribosomal protein L35 0.0255215
ARRDC3 arrestin domain containing 3 0.0251584
LAMB3 laminin, beta 3 0.025128
SEPTIN7 septin 7 0.0238686
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0234039
RPL13A ribosomal protein L13a 0.0232694
YBX3 Y box binding protein 3 0.0230891
GCLC glutamate-cysteine ligase, catalytic subunit 0.0222561
CD46 CD46 molecule, complement regulatory protein 0.0220348
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0219992
SET SET nuclear proto-oncogene 0.0212999
RPLP0 ribosomal protein, large, P0 0.0208465
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.020791
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0207899
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0205513
KIF5B kinesin family member 5B 0.0205266
RPS7 ribosomal protein S7 0.0200537
ENO1 enolase 1, (alpha) 0.0198552
PRRC2C proline-rich coiled-coil 2C 0.0196156
NEBL nebulette 0.0193695
CSNK1A1 casein kinase 1, alpha 1 0.0193271
BRD2 bromodomain containing 2 0.0192468
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0190935
HMGA1 high mobility group AT-hook 1 0.0190335
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0184825
CSDE1 cold shock domain containing E1, RNA-binding 0.0183822
DSPP dentin sialophosphoprotein 0.018046
BIRC3 baculoviral IAP repeat containing 3 0.0179944
RNF145 ring finger protein 145 0.0179681
COX6C cytochrome c oxidase subunit VIc 0.0179415
RSRC2 arginine/serine-rich coiled-coil 2 0.0177511
RPS15A ribosomal protein S15a 0.0173959
RPL10A ribosomal protein L10a 0.0173888
RUNX2 runt-related transcription factor 2 0.017328
PCM1 pericentriolar material 1 0.0173252

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.155807
FHIT fragile histidine triad -0.115315
RCOR1 REST corepressor 1 -0.115149
HMGA2 high mobility group AT-hook 2 -0.102119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.100882
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.100195
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0862407
RAD51B RAD51 paralog B -0.0810055
FERMT1 fermitin family member 1 -0.0809616
LAMA4 laminin, alpha 4 -0.0652454
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0625867
IER3 immediate early response 3 -0.0572889
TPT1 tumor protein, translationally-controlled 1 -0.054452
GPHN gephyrin -0.0536934
CUX1 cut-like homeobox 1 -0.051491
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0509605
FOSL1 FOS-like antigen 1 -0.0504148
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.050403
EXOC4 exocyst complex component 4 -0.0503605
MPRIP myosin phosphatase Rho interacting protein -0.0500578
CCSER1 coiled-coil serine-rich protein 1 -0.0496158
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0469879
SMYD3 SET and MYND domain containing 3 -0.0469653
EGR1 early growth response 1 -0.0467005
AKAP13 A kinase (PRKA) anchor protein 13 -0.0451494
DIAPH2 diaphanous-related formin 2 -0.0410736
ITGB4 integrin, beta 4 -0.0401422
EHBP1 EH domain binding protein 1 -0.040033
ATP5F1B ATP synthase F1 subunit beta -0.0382355
S100A6 S100 calcium binding protein A6 -0.037964
FLOT1 flotillin 1 -0.0376203
SBF2 SET binding factor 2 -0.0374447
IARS1 isoleucyl-tRNA synthetase 1 -0.0363148
RPL35A ribosomal protein L35a -0.0362299
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0362091
ITPKC inositol-trisphosphate 3-kinase C -0.0360566
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0350691
RPS21 ribosomal protein S21 -0.0347374
GPC5 glypican 5 -0.0344653
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0344185
MTAP methylthioadenosine phosphorylase -0.034253
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0342055
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0340039
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0338825
HDAC2 histone deacetylase 2 -0.0337141
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0328052
CMIP c-Maf inducing protein -0.0321639
FTH1 ferritin, heavy polypeptide 1 -0.0320811
RAB10 RAB10, member RAS oncogene family -0.0318789
CCND1 cyclin D1 -0.0316406
TENM3 teneurin transmembrane protein 3 -0.0314129
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0307235
DENND1A DENN/MADD domain containing 1A -0.0304777
POTEF POTE ankyrin domain family, member F -0.0304671
OSBPL10 oxysterol binding protein-like 10 -0.0303902
SNX9 sorting nexin 9 -0.0302154
KRT18 keratin 18, type I -0.0301863
VCL vinculin -0.0300701
ABR active BCR-related -0.0300632
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0299854
RAB7A RAB7A, member RAS oncogene family -0.0299251
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0298813
CDK13 cyclin-dependent kinase 13 -0.0293858
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0291927
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0287846
ANKRD17 ankyrin repeat domain 17 -0.0287245
SMAD3 SMAD family member 3 -0.0287032
RPL7A ribosomal protein L7a -0.0285948
ZNRF3 zinc and ring finger 3 -0.0282775
S100A10 S100 calcium binding protein A10 -0.0279452
VMP1 vacuole membrane protein 1 -0.0278749
FAF1 Fas (TNFRSF6) associated factor 1 -0.0276525
RPS15 ribosomal protein S15 -0.02721
RBM25 RNA binding motif protein 25 -0.0271964
ZBTB7C zinc finger and BTB domain containing 7C -0.0267642
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0267623
SRPK2 SRSF protein kinase 2 -0.0266467
TRAF3 TNF receptor-associated factor 3 -0.0266411
TMEM123 transmembrane protein 123 -0.0266343
KLK6 kallikrein-related peptidase 6 -0.0265265
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0265044
RREB1 ras responsive element binding protein 1 -0.0262942
PDS5A PDS5 cohesin associated factor A -0.02609
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0260576
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0260548
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0259868
AK1 adenylate kinase 1 -0.0258036
ACTN4 actinin, alpha 4 -0.0255074
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0252406
TNS3 tensin 3 -0.0249616
DEK DEK proto-oncogene -0.0248935
SPIDR scaffolding protein involved in DNA repair -0.0248708
SGMS2 sphingomyelin synthase 2 -0.0247742
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0247351
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0244903
RASAL2 RAS protein activator like 2 -0.0243507
ZNF207 zinc finger protein 207 -0.0241678
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0240152
MAP4 microtubule-associated protein 4 -0.0240034
ANKRD11 ankyrin repeat domain 11 -0.0236935