Diammonium Glycyrrhizinate_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.246163
STC1 stanniocalcin 1 0.180379
AKAP12 A kinase (PRKA) anchor protein 12 0.105804
B2M beta-2-microglobulin 0.095725
NDRG1 N-myc downstream regulated 1 0.0901537
MYH9 myosin, heavy chain 9, non-muscle 0.0860427
MT2A metallothionein 2A 0.0765201
RPL23 ribosomal protein L23 0.0750968
FTL ferritin, light polypeptide 0.0735635
EEF2 eukaryotic translation elongation factor 2 0.0701801
CXCL8 chemokine (C-X-C motif) ligand 8 0.0673615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0561565
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0545895
INHBA inhibin, beta A 0.0530096
RACK1 receptor for activated C kinase 1 0.0516465
RPS12 ribosomal protein S12 0.0515904
RPL37A ribosomal protein L37a 0.0479395
HLA-A major histocompatibility complex, class I, A 0.0475494
RPS8 ribosomal protein S8 0.0458041
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0449015
LOX lysyl oxidase 0.0439423
SOD2 superoxide dismutase 2, mitochondrial 0.0435221
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0424753
ENO1 enolase 1, (alpha) 0.0422682
LDHA lactate dehydrogenase A 0.0414405
RPL11 ribosomal protein L11 0.0411518
TMSB10 thymosin beta 10 0.0401032
RPL12 ribosomal protein L12 0.039856
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0396495
RPS3 ribosomal protein S3 0.0381595
RPL3 ribosomal protein L3 0.0379162
RPL26 ribosomal protein L26 0.0379137
RPS6 ribosomal protein S6 0.0378932
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0367767
HLA-B major histocompatibility complex, class I, B 0.0360171
AHNAK AHNAK nucleoprotein 0.0357466
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0350107
RPS19 ribosomal protein S19 0.0330893
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0329338
LOC112694756 uncharaterized LOC112694756 0.0321874
SRRM2 serine/arginine repetitive matrix 2 0.0313389
TM4SF1 transmembrane 4 L six family member 1 0.0311191
COL6A1 collagen, type VI, alpha 1 0.0305941
RPL37 ribosomal protein L37 0.0305825
EIF1 eukaryotic translation initiation factor 1 0.0301955
TPI1 triosephosphate isomerase 1 0.0301039
PKM pyruvate kinase, muscle 0.0294956
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0290307
RPL31 ribosomal protein L31 0.0284495
CD44 CD44 molecule (Indian blood group) 0.0284483
RPLP1 ribosomal protein, large, P1 0.0281206
RPL7 ribosomal protein L7 0.0280709
NAP1L1 nucleosome assembly protein 1-like 1 0.0280343
RPL13A ribosomal protein L13a 0.0276245
TPT1 tumor protein, translationally-controlled 1 0.0274616
RPS17 ribosomal protein S17 0.0271077
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270446
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0268033
RPL9 ribosomal protein L9 0.026303
PLEC plectin 0.0260866
HLA-E major histocompatibility complex, class I, E 0.0257948
RPL35A ribosomal protein L35a 0.0256643
ERRFI1 ERBB receptor feedback inhibitor 1 0.0253808
FLNA filamin A, alpha 0.0253108
RPL4 ribosomal protein L4 0.0251972
UBC ubiquitin C 0.0250107
RPL19 ribosomal protein L19 0.0242152
RPL34 ribosomal protein L34 0.0240517
YBX1 Y box binding protein 1 0.0237579
TRIO trio Rho guanine nucleotide exchange factor 0.023695
HSPA8 heat shock 70kDa protein 8 0.0235556
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0231186
PGK1 phosphoglycerate kinase 1 0.0230901
ADM adrenomedullin 0.0225954
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0222522
RPS4X ribosomal protein S4, X-linked 0.0217205
RPS27 ribosomal protein S27 0.0215806
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0215775
RPS27A ribosomal protein S27a 0.0214272
IGFBP7 insulin-like growth factor binding protein 7 0.0213914
SEPTIN9 septin 9 0.0205463
PTMA prothymosin, alpha 0.0205077
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0203561
RPL30 ribosomal protein L30 0.0201109
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0198876
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198726
SQSTM1 sequestosome 1 0.0197089
NFE2L1 nuclear factor, erythroid 2-like 1 0.0195488
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195342
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.01945
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0193696
SFTPA2 surfactant protein A2 0.0190919
APLP2 amyloid beta (A4) precursor-like protein 2 0.0190278
HLA-C major histocompatibility complex, class I, C 0.0186587
GOLGB1 golgin B1 0.018619
TGFBI transforming growth factor, beta-induced, 68kDa 0.0185489
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0183757
RPL36 ribosomal protein L36 0.0182139
MCL1 myeloid cell leukemia 1 0.017677
TPM3 tropomyosin 3 0.017677

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.1551
COL1A1 collagen, type I, alpha 1 -0.152703
PRKG1 protein kinase, cGMP-dependent, type I -0.105188
COL1A2 collagen, type I, alpha 2 -0.0910817
ADGRB3 adhesion G protein-coupled receptor B3 -0.0898682
COL6A3 collagen, type VI, alpha 3 -0.0873924
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0763848
OXR1 oxidation resistance 1 -0.0704263
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0661025
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0589681
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0560376
CDH13 cadherin 13 -0.0548249
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0516427
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0505858
HMGA2 high mobility group AT-hook 2 -0.0505596
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0465243
EXT1 exostosin glycosyltransferase 1 -0.0463277
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0455655
SASH1 SAM and SH3 domain containing 1 -0.0447422
ATP13A3 ATPase type 13A3 -0.044676
ZEB1 zinc finger E-box binding homeobox 1 -0.0440097
KIAA1549L KIAA1549-like -0.0425331
COL6A2 collagen, type VI, alpha 2 -0.0391743
GLIS3 GLIS family zinc finger 3 -0.0386428
NAV1 neuron navigator 1 -0.0384627
PDE8A phosphodiesterase 8A -0.0370465
COL5A3 collagen, type V, alpha 3 -0.0365231
FRMD4A FERM domain containing 4A -0.0350747
RAI14 retinoic acid induced 14 -0.0345372
CLMP CXADR-like membrane protein -0.0331606
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0324508
ARHGAP24 Rho GTPase activating protein 24 -0.0312172
ANKRD28 ankyrin repeat domain 28 -0.0309986
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0306239
PRRX1 paired related homeobox 1 -0.0305731
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0284432
CCDC102B coiled-coil domain containing 102B -0.0282705
LYST lysosomal trafficking regulator -0.028009
PTPRG protein tyrosine phosphatase, receptor type, G -0.0278229
PRR16 proline rich 16 -0.0273983
TMEM165 transmembrane protein 165 -0.0273622
MED13L mediator complex subunit 13-like -0.0266682
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0257144
FOXP1 forkhead box P1 -0.0254041
GREM1 gremlin 1, DAN family BMP antagonist -0.0246835
CALD1 caldesmon 1 -0.0239151
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0232348
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0230424
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0228064
MYO10 myosin X -0.0227361
LTBP1 latent transforming growth factor beta binding protein 1 -0.0226323
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0222532
RASAL2 RAS protein activator like 2 -0.0207637
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0206215
NF1 neurofibromin 1 -0.0205082
PDE4B phosphodiesterase 4B, cAMP-specific -0.0204984
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0204086
DIAPH2 diaphanous-related formin 2 -0.020339
NRP1 neuropilin 1 -0.0200717
VCAN versican -0.0200686
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.019788
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0197697
ABI3BP ABI family, member 3 (NESH) binding protein -0.0197567
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0197357
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0193375
CAV1 caveolin 1, caveolae protein, 22kDa -0.0193152
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0188711
OSMR oncostatin M receptor -0.0187512
EDNRA endothelin receptor type A -0.0184353
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0183383
CHSY3 chondroitin sulfate synthase 3 -0.0182531
SORBS2 sorbin and SH3 domain containing 2 -0.0181789
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.018148
DNER delta/notch-like EGF repeat containing -0.0180312
ANTXR2 anthrax toxin receptor 2 -0.0178357
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0177837
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.0177208
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0176745
VEGFC vascular endothelial growth factor C -0.0173915
HAS2 hyaluronan synthase 2 -0.0173558
FBN1 fibrillin 1 -0.0172467
NCKAP5 NCK-associated protein 5 -0.0171742
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0168838
RTN4 reticulon 4 -0.0168369
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0165914
TCF12 transcription factor 12 -0.0165043
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0163176
NOTCH3 notch 3 -0.0162166
JMJD1C jumonji domain containing 1C -0.0161625
TUBB6 tubulin, beta 6 class V -0.0161243
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0161024
S100A6 S100 calcium binding protein A6 -0.0160016
MSRB3 methionine sulfoxide reductase B3 -0.0159977
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0159925
ZFAND3 zinc finger, AN1-type domain 3 -0.015962
GLI2 GLI family zinc finger 2 -0.0159529
SAMD3 sterile alpha motif domain containing 3 -0.0159103
SOCS5 suppressor of cytokine signaling 5 -0.0157249
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0156545
SEPTIN11 septin 11 -0.0154214