Diarrhea Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. (Human Disease Ontology, DOID_13250)
External Link https://www.disgenet.org/browser/0/1/0/C0474496
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Genes

129 genes associated with the disease Diarrhea in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADCY3 adenylate cyclase 3
ADIPOQ adiponectin, C1Q and collagen domain containing
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
APOE apolipoprotein E
AQP8 aquaporin 8
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
C4BPA complement component 4 binding protein, alpha
CASR calcium-sensing receptor
CCL11 chemokine (C-C motif) ligand 11
CCL20 chemokine (C-C motif) ligand 20
CD68 CD68 molecule
CDC42 cell division cycle 42
CFH complement factor H
CFL1 cofilin 1 (non-muscle)
CLDN15 claudin 15
CLDN2 claudin 2
CLDN7 claudin 7
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPE carboxypeptidase E
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DGAT1 diacylglycerol O-acyltransferase 1
EPCAM epithelial cell adhesion molecule
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FGF19 fibroblast growth factor 19
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FUT2 fucosyltransferase 2 (secretor status included)
GCG glucagon
GFAP glial fibrillary acidic protein
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRAP2 GRB2-related adaptor protein 2
GSK3B glycogen synthase kinase 3 beta
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GUCA2B guanylate cyclase activator 2B (uroguanylin)
GUCY2C guanylate cyclase 2C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL10 interleukin 10
IL6 interleukin 6
KLB klotho beta
LAMP3 lysosomal-associated membrane protein 3
LEP leptin
LSAMP limbic system-associated membrane protein
MAG myelin associated glycoprotein
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MLXIPL MLX interacting protein-like
MPO myeloperoxidase
MYLK myosin light chain kinase
MYLK2 myosin light chain kinase 2
MYLK3 myosin light chain kinase 3
NEUROG3 neurogenin 3
NGF nerve growth factor (beta polypeptide)
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NXPH1 neurexophilin 1
OCLN occludin
OPRM1 opioid receptor, mu 1
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene)
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PDZD2 PDZ domain containing 2
PDZD3 PDZ domain containing 3
PLG plasminogen
PLVAP plasmalemma vesicle associated protein
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PRF1 perforin 1 (pore forming protein)
PRKG2 protein kinase, cGMP-dependent, type II
PRNP prion protein
PRSS57 protease, serine, 57
RAP1A RAP1A, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBP2 retinol binding protein 2, cellular
RETN resistin
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
S100A10 S100 calcium binding protein A10
SAA1 serum amyloid A1
SAA2 serum amyloid A2
SCN9A sodium channel, voltage gated, type IX alpha subunit
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SGSM3 small G protein signaling modulator 3
SH2D3A SH2 domain containing 3A
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STX1A syntaxin 1A (brain)
STX2 syntaxin 2
STX3 syntaxin 3
SYNGR3 synaptogyrin 3
TAC1 tachykinin, precursor 1
TAPBP TAP binding protein (tapasin)
TARDBP TAR DNA binding protein
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TMEM106B transmembrane protein 106B
TNF tumor necrosis factor
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPH1 tryptophan hydroxylase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VIP vasoactive intestinal peptide
WNT2B wingless-type MMTV integration site family, member 2B