| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/20054892 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Dichlorisone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.62 |
| TTYH3 | tweety family member 3 | 0.56 |
| ALMS1 | Alstrom syndrome protein 1 | 0.56 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.54 |
| KLF2 | Kruppel-like factor 2 | 0.54 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.53 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.52 |
| ZBTB6 | zinc finger and BTB domain containing 6 | 0.5 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.47 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | 0.45 |
| CCDC15 | coiled-coil domain containing 15 | 0.44 |
| RPL26 | ribosomal protein L26 | 0.43 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.43 |
| LMTK2 | lemur tyrosine kinase 2 | 0.4 |
| ZNF707 | zinc finger protein 707 | 0.4 |
| FAT2 | FAT atypical cadherin 2 | 0.4 |
| ZNF525 | zinc finger protein 525 | 0.4 |
| C19ORF25 | chromosome 19 open reading frame 25 | 0.4 |
| M1AP | meiosis 1 associated protein | 0.4 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.39 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.36 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.36 |
| MICB | MHC class I polypeptide-related sequence B | 0.35 |
| PTGES | prostaglandin E synthase | 0.35 |
| ADSS1 | adenylosuccinate synthase 1 | 0.34 |
| RNF115 | ring finger protein 115 | 0.34 |
| PWWP2B | PWWP domain containing 2B | 0.34 |
| RAB24 | RAB24, member RAS oncogene family | 0.33 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.32 |
| EMC10 | ER membrane protein complex subunit 10 | 0.32 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | 0.32 |
| CDX2 | caudal type homeobox 2 | 0.32 |
| MIDN | midnolin | 0.31 |
| PER1 | period circadian clock 1 | 0.31 |
| FN1 | fibronectin 1 | 0.31 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.3 |
| COMMD8 | COMM domain containing 8 | 0.3 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.3 |
| DIPK1B | divergent protein kinase domain 1B | 0.3 |
| HES1 | hes family bHLH transcription factor 1 | 0.3 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.3 |
| LYST | lysosomal trafficking regulator | 0.29 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.29 |
| TRIM37 | tripartite motif containing 37 | 0.29 |
| GATA2 | GATA binding protein 2 | 0.29 |
| CIC | capicua transcriptional repressor | 0.29 |
| RARA | retinoic acid receptor, alpha | 0.29 |
| WRB | tryptophan rich basic protein | 0.28 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.28 |
| ZNF639 | zinc finger protein 639 | 0.28 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.28 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | 0.28 |
| ZNF496 | zinc finger protein 496 | 0.28 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.27 |
| FAM135B | family with sequence similarity 135, member B | 0.27 |
| PWWP3B | PWWP domain containing 3B | 0.27 |
| GRAMD1A | GRAM domain containing 1A | 0.27 |
| TMSB10 | thymosin beta 10 | 0.27 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.26 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 0.26 |
| ZFHX4 | zinc finger homeobox 4 | 0.26 |
| FKBP5 | FK506 binding protein 5 | 0.25 |
| ZNF618 | zinc finger protein 618 | 0.25 |
| KLHDC8B | kelch domain containing 8B | 0.25 |
| KIAA0556 | KIAA0556 | 0.25 |
| SH2B3 | SH2B adaptor protein 3 | 0.25 |
| KLHL18 | kelch-like family member 18 | 0.25 |
| COMMD6 | COMM domain containing 6 | 0.25 |
| HIST2H3A | histone cluster 2, H3a | 0.25 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.25 |
| TRAF5 | TNF receptor-associated factor 5 | 0.25 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.25 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.24 |
| MXRA7 | matrix-remodelling associated 7 | 0.24 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.24 |
| CCDC127 | coiled-coil domain containing 127 | 0.24 |
| FGA | fibrinogen alpha chain | 0.24 |
| MT2A | metallothionein 2A | 0.24 |
| PFDN1 | prefoldin subunit 1 | 0.24 |
| F2R | coagulation factor II (thrombin) receptor | 0.24 |
| SQLE | squalene epoxidase | 0.24 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.24 |
| SNX19 | sorting nexin 19 | 0.24 |
| DCTPP1 | dCTP pyrophosphatase 1 | 0.24 |
| ZC3H14 | zinc finger CCCH-type containing 14 | 0.24 |
| BANF1 | barrier to autointegration factor 1 | 0.23 |
| CCDC138 | coiled-coil domain containing 138 | 0.23 |
| HYPK | huntingtin interacting protein K | 0.23 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.23 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | 0.23 |
| SNRK | SNF related kinase | 0.23 |
| PHF1 | PHD finger protein 1 | 0.23 |
| CNTLN | centlein, centrosomal protein | 0.23 |
| SH3D19 | SH3 domain containing 19 | 0.23 |
| ABHD15 | abhydrolase domain containing 15 | 0.23 |
| TMEM40 | transmembrane protein 40 | 0.23 |
| E2F2 | E2F transcription factor 2 | 0.23 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.23 |
| KLHL2 | kelch-like family member 2 | 0.23 |
| PCNX3 | pecanex 3 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SKIL | SKI-like proto-oncogene | -2.83 |
| KALRN | kalirin, RhoGEF kinase | -1.98 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -1.93 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -1.92 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -1.9 |
| ADCY10 | adenylate cyclase 10 (soluble) | -1.67 |
| ICK | intestinal cell (MAK-like) kinase | -1.15 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -1.14 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.12 |
| SYN2 | synapsin II | -0.89 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.86 |
| ZNF444 | zinc finger protein 444 | -0.83 |
| TAF8 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | -0.8 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.76 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.73 |
| SULF2 | sulfatase 2 | -0.68 |
| FKTN | fukutin | -0.66 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.66 |
| CCDC158 | coiled-coil domain containing 158 | -0.66 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.64 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.62 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.6 |
| IFFO2 | intermediate filament family orphan 2 | -0.57 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.56 |
| COL6A2 | collagen, type VI, alpha 2 | -0.54 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.53 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.5 |
| ZFP30 | ZFP30 zinc finger protein | -0.5 |
| RNF220 | ring finger protein 220 | -0.5 |
| ZNF587 | zinc finger protein 587 | -0.48 |
| SELENOI | selenoprotein I | -0.47 |
| METTL22 | methyltransferase like 22 | -0.47 |
| CAPN6 | calpain 6 | -0.46 |
| NRXN3 | neurexin 3 | -0.46 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.46 |
| ICAM1 | intercellular adhesion molecule 1 | -0.45 |
| BCL9 | B-cell CLL/lymphoma 9 | -0.42 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.41 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | -0.41 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.41 |
| ZNF611 | zinc finger protein 611 | -0.41 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.41 |
| ZNF503 | zinc finger protein 503 | -0.41 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -0.4 |
| DES | desmin | -0.4 |
| CCNE1 | cyclin E1 | -0.4 |
| ZNF286B | zinc finger protein 286B | -0.39 |
| PRG4 | proteoglycan 4 | -0.39 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | -0.39 |
| ITPKB | inositol-trisphosphate 3-kinase B | -0.39 |
| BPTF | bromodomain PHD finger transcription factor | -0.38 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.37 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.37 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.37 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.37 |
| MCOLN3 | mucolipin 3 | -0.37 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.36 |
| CILP2 | cartilage intermediate layer protein 2 | -0.36 |
| ADAM21 | ADAM metallopeptidase domain 21 | -0.35 |
| TMEM173 | transmembrane protein 173 | -0.35 |
| DCAF17 | DDB1 and CUL4 associated factor 17 | -0.35 |
| ERCC6 | excision repair cross-complementation group 6 | -0.35 |
| NUDT12 | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | -0.35 |
| NRF1 | nuclear respiratory factor 1 | -0.35 |
| MKRN1 | makorin ring finger protein 1 | -0.34 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.34 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.34 |
| MOCS1 | molybdenum cofactor synthesis 1 | -0.33 |
| USP19 | ubiquitin specific peptidase 19 | -0.33 |
| TTC14 | tetratricopeptide repeat domain 14 | -0.33 |
| FHOD3 | formin homology 2 domain containing 3 | -0.33 |
| PLEK | pleckstrin | -0.33 |
| TBC1D25 | TBC1 domain family, member 25 | -0.32 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.32 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | -0.32 |
| DST | dystonin | -0.32 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.31 |
| ZNF317 | zinc finger protein 317 | -0.31 |
| MIS12 | MIS12 kinetochore complex component | -0.31 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.31 |
| FAM102B | family with sequence similarity 102, member B | -0.3 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.3 |
| CCDC112 | coiled-coil domain containing 112 | -0.3 |
| PLSCR3 | phospholipid scramblase 3 | -0.3 |
| RAB40C | RAB40C, member RAS oncogene family | -0.3 |
| PRDM4 | PR domain containing 4 | -0.3 |
| BDNF | brain-derived neurotrophic factor | -0.3 |
| NCOA1 | nuclear receptor coactivator 1 | -0.29 |
| EPHA5 | EPH receptor A5 | -0.29 |
| PPT2 | palmitoyl-protein thioesterase 2 | -0.29 |
| FBXO44 | F-box protein 44 | -0.29 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.29 |
| WASHC2C | WASH complex subunit 2C | -0.29 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.28 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | -0.28 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.28 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.28 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.28 |
| NCOA6 | nuclear receptor coactivator 6 | -0.28 |
| FAM122A | family with sequence similarity 122A | -0.28 |
