Diclofenac Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. (Chemical Entities of Biological Interest Ontology, CHEBI_47381)
External Link http://ctdbase.org/detail.go?type=chem&acc=D004008
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Genes

98 genes/proteins interacting with the chemical Diclofenac from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ALB albumin
AQP2 aquaporin 2 (collecting duct)
ASIC3 acid sensing (proton gated) ion channel 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BID BH3 interacting domain death agonist
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
EDN1 endothelin 1
EGF epidermal growth factor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
FABP1 fatty acid binding protein 1, liver
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL10 interleukin 10
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLK1 kallikrein 1
LCN2 lipocalin 2
MPO myeloperoxidase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCNA proliferating cell nuclear antigen
PLAU plasminogen activator, urokinase
PPARG peroxisome proliferator-activated receptor gamma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
TNF tumor necrosis factor
TTR transthyretin
TYR tyrosinase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VIM vimentin
ZEB1 zinc finger E-box binding homeobox 1