Diethylstilbestrol Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/448537
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Genes

197 proteins with high or low expression in Diethylstilbestrol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MYH4 myosin, heavy chain 4, skeletal muscle 1.87
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.0
NALCN sodium leak channel, non selective 0.68
ABHD2 abhydrolase domain containing 2 0.62
RNF4 ring finger protein 4 0.56
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.56
SYT17 synaptotagmin XVII 0.55
CCND3 cyclin D3 0.53
ANKRD10 ankyrin repeat domain 10 0.53
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.52
KIAA1210 KIAA1210 0.51
CYBA cytochrome b-245, alpha polypeptide 0.51
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.51
SYN1 synapsin I 0.49
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.49
GINM1 glycoprotein integral membrane 1 0.48
SEPTIN4 septin 4 0.48
ZNF160 zinc finger protein 160 0.47
ZNF766 zinc finger protein 766 0.47
ALPK3 alpha-kinase 3 0.46
GIN1 gypsy retrotransposon integrase 1 0.44
EPHA4 EPH receptor A4 0.44
MSX1 msh homeobox 1 0.43
ZNF136 zinc finger protein 136 0.43
DNLZ DNL-type zinc finger 0.43
CAV2 caveolin 2 0.41
USP19 ubiquitin specific peptidase 19 0.41
TACC3 transforming, acidic coiled-coil containing protein 3 0.4
PHPT1 phosphohistidine phosphatase 1 0.39
PPP1R2B PPP1R2 family member B 0.39
TP53 tumor protein p53 0.38
YAE1 YAE1 maturation factor of ABCE1 0.38
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.38
LMX1B LIM homeobox transcription factor 1, beta 0.38
FGB fibrinogen beta chain 0.38
PIP prolactin-induced protein 0.36
SKA3 spindle and kinetochore associated complex subunit 3 0.36
FGF19 fibroblast growth factor 19 0.35
SUMO1 small ubiquitin-like modifier 1 0.35
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.35
ZNF354B zinc finger protein 354B 0.35
CHPF chondroitin polymerizing factor 0.34
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.34
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.33
GK5 glycerol kinase 5 (putative) 0.33
CST6 cystatin E/M 0.33
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.33
MT1X metallothionein 1X 0.32
ADIPOR1 adiponectin receptor 1 0.32
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.32
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.31
F13A1 coagulation factor XIII, A1 polypeptide 0.31
ZFHX4 zinc finger homeobox 4 0.31
SPICE1 spindle and centriole associated protein 1 0.31
CCDC85C coiled-coil domain containing 85C 0.31
SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.31
BAG3 BCL2-associated athanogene 3 0.31
DERPC DERPC proline and glycine rich nuclear protein 0.3
HDIP1 HDAC and MIER1 interacting protein 1 0.3
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 0.3
MUC16 mucin 16, cell surface associated 0.3
FAM110C family with sequence similarity 110, member C 0.3
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 0.29
ZNF3 zinc finger protein 3 0.29
TMEM64 transmembrane protein 64 0.29
SPEG SPEG complex locus 0.29
STC2 stanniocalcin 2 0.29
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.29
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.29
FUBP1 far upstream element (FUSE) binding protein 1 0.29
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.28
ZNF729 zinc finger protein 729 0.28
ZNRD2 zinc ribbon domain containing 2 0.28
ZCCHC24 zinc finger, CCHC domain containing 24 0.28
GEMIN6 gem (nuclear organelle) associated protein 6 0.28
STMN1 stathmin 1 0.27
HIPK1 homeodomain interacting protein kinase 1 0.27
KMT5B lysine methyltransferase 5B 0.27
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.27
BSN bassoon presynaptic cytomatrix protein 0.27
ERMARD ER membrane-associated RNA degradation 0.27
VWA1 von Willebrand factor A domain containing 1 0.26
TROAP trophinin associated protein 0.26
RND3 Rho family GTPase 3 0.26
ZFAT zinc finger and AT hook domain containing 0.26
CLU clusterin 0.26
AK2 adenylate kinase 2 0.26
ZNF16 zinc finger protein 16 0.26
VIM vimentin 0.26
PHLDB3 pleckstrin homology-like domain, family B, member 3 0.26
CKM creatine kinase, muscle 0.26
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.25
CD58 CD58 molecule 0.25
AEN apoptosis enhancing nuclease 0.25
BHLHA15 basic helix-loop-helix family, member a15 0.25
DCAF10 DDB1 and CUL4 associated factor 10 0.25

low expression

Symbol Name Standardized Value
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -1.14
C5ORF24 chromosome 5 open reading frame 24 -0.78
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.61
DBNL drebrin-like -0.55
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.49
RAD52 RAD52 homolog (S. cerevisiae) -0.49
TRIM9 tripartite motif containing 9 -0.49
RNF145 ring finger protein 145 -0.48
JPT1 Jupiter microtubule associated homolog 1 -0.48
SH2B3 SH2B adaptor protein 3 -0.47
SCLT1 sodium channel and clathrin linker 1 -0.45
VCPKMT valosin containing protein lysine (K) methyltransferase -0.45
ZNF652 zinc finger protein 652 -0.44
FAR1 fatty acyl CoA reductase 1 -0.42
ZNF628 zinc finger protein 628 -0.41
BRWD3 bromodomain and WD repeat domain containing 3 -0.4
B2M beta-2-microglobulin -0.38
JDP2 Jun dimerization protein 2 -0.37
TMEM128 transmembrane protein 128 -0.35
FAM241A family with sequence similarity 241 member A -0.34
ATE1 arginyltransferase 1 -0.34
XIRP1 xin actin binding repeat containing 1 -0.33
JARID2 jumonji, AT rich interactive domain 2 -0.33
FURIN furin (paired basic amino acid cleaving enzyme) -0.32
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.32
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -0.32
TSKU tsukushi, small leucine rich proteoglycan -0.31
MEF2A myocyte enhancer factor 2A -0.3
TRMT61A tRNA methyltransferase 61A -0.3
PLIN2 perilipin 2 -0.3
DSTYK dual serine/threonine and tyrosine protein kinase -0.29
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.29
PRDM4 PR domain containing 4 -0.29
ZDHHC23 zinc finger, DHHC-type containing 23 -0.29
PDE7A phosphodiesterase 7A -0.28
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -0.28
ZNF444 zinc finger protein 444 -0.27
TMEM177 transmembrane protein 177 -0.27
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -0.27
TSPAN9 tetraspanin 9 -0.26
CCDC91 coiled-coil domain containing 91 -0.26
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -0.26
SOCS2 suppressor of cytokine signaling 2 -0.25
SAMD12 sterile alpha motif domain containing 12 -0.25
KLHL29 kelch-like family member 29 -0.25
NEU1 sialidase 1 (lysosomal sialidase) -0.24
DUSP6 dual specificity phosphatase 6 -0.24
ZNF428 zinc finger protein 428 -0.24
ABLIM3 actin binding LIM protein family, member 3 -0.24
FZD3 frizzled class receptor 3 -0.24
KIAA0232 KIAA0232 -0.24
MYH15 myosin, heavy chain 15 -0.24
ADCK1 aarF domain containing kinase 1 -0.24
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.23
TMEM260 transmembrane protein 260 -0.23
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -0.23
TACSTD2 tumor-associated calcium signal transducer 2 -0.23
HBA1 hemoglobin, alpha 1 -0.23
TMEM39B transmembrane protein 39B -0.23
REPS2 RALBP1 associated Eps domain containing 2 -0.23
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -0.23
NKAPD1 NKAP domain containing 1 -0.22
CIAO2B cytosolic iron-sulfur assembly component 2B -0.22
CALB2 calbindin 2 -0.22
EMC10 ER membrane protein complex subunit 10 -0.22
ZNF669 zinc finger protein 669 -0.22
NBEA neurobeachin -0.22
PDIA4 protein disulfide isomerase family A, member 4 -0.22
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.22
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.22
PARP16 poly (ADP-ribose) polymerase family, member 16 -0.22
MED31 mediator complex subunit 31 -0.22
FBXL4 F-box and leucine-rich repeat protein 4 -0.22
MST1R macrophage stimulating 1 receptor -0.22
SNAP91 synaptosomal-associated protein, 91kDa -0.21
HIPK2 homeodomain interacting protein kinase 2 -0.21
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -0.21
ZNF839 zinc finger protein 839 -0.21
ARG2 arginase 2 -0.21
ACY1 aminoacylase 1 -0.21
MRPL12 mitochondrial ribosomal protein L12 -0.21
EWSR1 EWS RNA-binding protein 1 -0.21
NEK3 NIMA-related kinase 3 -0.21
LMTK2 lemur tyrosine kinase 2 -0.21
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -0.21
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -0.2
MRPL16 mitochondrial ribosomal protein L16 -0.2
BCORL1 BCL6 corepressor-like 1 -0.2
RAB3IP RAB3A interacting protein -0.19
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -0.19
RTN1 reticulon 1 -0.19
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.19
REEP3 receptor accessory protein 3 -0.19
METTL7A methyltransferase like 7A -0.19
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.19
AGRN agrin -0.18
AARS alanyl-tRNA synthetase -0.18
CNTNAP1 contactin associated protein 1 -0.18
CREG1 cellular repressor of E1A-stimulated genes 1 -0.18
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.18