| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.22841 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.195908 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.15601 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.152343 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.130667 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.118398 |
| PODXL | podocalyxin-like | 0.118228 |
| COL5A1 | collagen, type V, alpha 1 | 0.101776 |
| CDH13 | cadherin 13 | 0.101383 |
| COL5A2 | collagen, type V, alpha 2 | 0.101277 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0945372 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0934502 |
| EGFR | epidermal growth factor receptor | 0.0908497 |
| NAV1 | neuron navigator 1 | 0.0884419 |
| AHNAK | AHNAK nucleoprotein | 0.0853935 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0829191 |
| COL3A1 | collagen, type III, alpha 1 | 0.08228 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0776123 |
| POTEF | POTE ankyrin domain family, member F | 0.0749397 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0707761 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0695189 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0684671 |
| TPM4 | tropomyosin 4 | 0.0678205 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0671288 |
| EFNA5 | ephrin-A5 | 0.0656945 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0634455 |
| APP | amyloid beta (A4) precursor protein | 0.0628053 |
| STC1 | stanniocalcin 1 | 0.0603062 |
| LDHA | lactate dehydrogenase A | 0.0580654 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0548649 |
| PKM | pyruvate kinase, muscle | 0.0545848 |
| FLNB | filamin B, beta | 0.0545429 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0538288 |
| NAV2 | neuron navigator 2 | 0.0529647 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0524786 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.052197 |
| SEPTIN9 | septin 9 | 0.051442 |
| TPM3 | tropomyosin 3 | 0.0513778 |
| MAP1B | microtubule-associated protein 1B | 0.0511958 |
| RUNX1 | runt-related transcription factor 1 | 0.0497673 |
| GLIS3 | GLIS family zinc finger 3 | 0.049448 |
| ENO1 | enolase 1, (alpha) | 0.0494093 |
| CENPF | centromere protein F, 350/400kDa | 0.0492725 |
| FSTL1 | follistatin-like 1 | 0.0490971 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0481384 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0466431 |
| UBC | ubiquitin C | 0.0465926 |
| ATP13A3 | ATPase type 13A3 | 0.0463815 |
| FN1 | fibronectin 1 | 0.04627 |
| LOX | lysyl oxidase | 0.0457862 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0457607 |
| ASPH | aspartate beta-hydroxylase | 0.0455765 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0440085 |
| HDAC9 | histone deacetylase 9 | 0.0435886 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0421228 |
| DST | dystonin | 0.0419978 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0413005 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0412418 |
| FLNA | filamin A, alpha | 0.0408149 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0404946 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0395847 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0386738 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0380854 |
| MYOF | myoferlin | 0.0371892 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0369574 |
| EXT1 | exostosin glycosyltransferase 1 | 0.03587 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0357081 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0348132 |
| SUCNR1 | succinate receptor 1 | 0.0346182 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0346061 |
| TENM3 | teneurin transmembrane protein 3 | 0.0344696 |
| FRMD4A | FERM domain containing 4A | 0.0344123 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0342082 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0338045 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0336129 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0334468 |
| MCL1 | myeloid cell leukemia 1 | 0.0327469 |
| CALR | calreticulin | 0.0324994 |
| CALU | calumenin | 0.0322754 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0317291 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0315097 |
| CD99 | CD99 molecule | 0.0304355 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0302383 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0302237 |
| NEK7 | NIMA-related kinase 7 | 0.0300909 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0300826 |
| TAGLN2 | transgelin 2 | 0.0298765 |
| PLAT | plasminogen activator, tissue | 0.0298648 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0292113 |
| JUN | jun proto-oncogene | 0.0287206 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.028513 |
| CDK6 | cyclin-dependent kinase 6 | 0.0283328 |
| CCND1 | cyclin D1 | 0.0282799 |
| TAOK1 | TAO kinase 1 | 0.0277879 |
| MSN | moesin | 0.02772 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0276306 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0270017 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.026945 |
| PGK1 | phosphoglycerate kinase 1 | 0.026924 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0267306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.156425 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0787935 |
| TMSB10 | thymosin beta 10 | -0.0419877 |
| PTMA | prothymosin, alpha | -0.0401017 |
| FTL | ferritin, light polypeptide | -0.036748 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0340661 |
| HLA-B | major histocompatibility complex, class I, B | -0.0334138 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0330901 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0286594 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0282256 |
| IER3 | immediate early response 3 | -0.0258362 |
| MT1X | metallothionein 1X | -0.0254313 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0246793 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0234589 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0230183 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.022807 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0226133 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0219574 |
| RPL35A | ribosomal protein L35a | -0.0218323 |
| IRF1 | interferon regulatory factor 1 | -0.0214011 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0209558 |
| RPS19 | ribosomal protein S19 | -0.0208685 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0203153 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0201835 |
| TMOD1 | tropomodulin 1 | -0.0199442 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0198896 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0194099 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0189561 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0186678 |
| FRMD5 | FERM domain containing 5 | -0.0186328 |
| RPL23 | ribosomal protein L23 | -0.0186058 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0183961 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0182995 |
| HIP1 | huntingtin interacting protein 1 | -0.0181343 |
| RPLP1 | ribosomal protein, large, P1 | -0.0174731 |
| RPL36 | ribosomal protein L36 | -0.0173691 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0171568 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.017121 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0167918 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0164917 |
| WTAP | Wilms tumor 1 associated protein | -0.0161474 |
| RPL34 | ribosomal protein L34 | -0.015966 |
| ADM | adrenomedullin | -0.0158428 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.015677 |
| OPTN | optineurin | -0.0156364 |
| FAM162A | family with sequence similarity 162, member A | -0.0151815 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0150725 |
| ANK2 | ankyrin 2, neuronal | -0.0149194 |
| ABI1 | abl-interactor 1 | -0.0147729 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0145892 |
| PRKD1 | protein kinase D1 | -0.0144846 |
| RPS3 | ribosomal protein S3 | -0.0143789 |
| RPL26 | ribosomal protein L26 | -0.0143343 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0141375 |
| UBTD2 | ubiquitin domain containing 2 | -0.0140864 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0140753 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0140402 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0139844 |
| CXXC5 | CXXC finger protein 5 | -0.0139775 |
| DENND4A | DENN/MADD domain containing 4A | -0.0139375 |
| FNBP1L | formin binding protein 1-like | -0.013768 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.013746 |
| RTN4 | reticulon 4 | -0.0136586 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0136368 |
| RPL12 | ribosomal protein L12 | -0.0133633 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0132377 |
| GNAS | GNAS complex locus | -0.0131495 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0130907 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0130657 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0129143 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0128953 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0126582 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0126223 |
| MEF2A | myocyte enhancer factor 2A | -0.012584 |
| CLINT1 | clathrin interactor 1 | -0.0125542 |
| RPL28 | ribosomal protein L28 | -0.0125048 |
| RPS6 | ribosomal protein S6 | -0.0124963 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0124898 |
| FAM13B | family with sequence similarity 13, member B | -0.0123837 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0123621 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0121697 |
| USP3 | ubiquitin specific peptidase 3 | -0.0121302 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0120947 |
| MATR3 | matrin 3 | -0.012017 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.011988 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0118224 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0117828 |
| TXNIP | thioredoxin interacting protein | -0.0116972 |
| FAM13A | family with sequence similarity 13, member A | -0.0114809 |
| KIF13A | kinesin family member 13A | -0.0113799 |
| SEC11A | SEC11 homolog A (S. cerevisiae) | -0.0110131 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0109793 |
| KLF6 | Kruppel-like factor 6 | -0.0108771 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0107911 |
| BBX | bobby sox homolog (Drosophila) | -0.010789 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.010772 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.0107585 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0106816 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0106209 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0106098 |
