Digitoxin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.190996
TXNRD1 thioredoxin reductase 1 0.120872
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.109348
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0996144
ERRFI1 ERBB receptor feedback inhibitor 1 0.0869234
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0861112
SLC38A2 solute carrier family 38, member 2 0.0779786
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0745616
UBC ubiquitin C 0.0729957
EEF2 eukaryotic translation elongation factor 2 0.0703695
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0632467
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0573148
EIF4A2 eukaryotic translation initiation factor 4A2 0.0529388
KDM3A lysine (K)-specific demethylase 3A 0.0524798
CXADR coxsackie virus and adenovirus receptor 0.0522248
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0520693
CPOX coproporphyrinogen oxidase 0.0487597
KIF5B kinesin family member 5B 0.0481524
CAMTA1 calmodulin binding transcription activator 1 0.0481115
BIRC6 baculoviral IAP repeat containing 6 0.0476892
NEK7 NIMA-related kinase 7 0.0470988
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0460204
PCBP2 poly(rC) binding protein 2 0.0460106
ECT2 epithelial cell transforming 2 0.0454557
XPO1 exportin 1 0.0453987
HSPA4 heat shock 70kDa protein 4 0.0419084
LDHA lactate dehydrogenase A 0.0417447
ASPH aspartate beta-hydroxylase 0.0416529
SQSTM1 sequestosome 1 0.0409052
FXR1 fragile X mental retardation, autosomal homolog 1 0.0408982
ATP11A ATPase, class VI, type 11A 0.0398863
RRM2 ribonucleotide reductase M2 0.039819
BIRC2 baculoviral IAP repeat containing 2 0.0395005
TENM3 teneurin transmembrane protein 3 0.0392263
LOC112694756 uncharaterized LOC112694756 0.0391236
IPO7 importin 7 0.0388859
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0384127
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0382939
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0378325
ZNF217 zinc finger protein 217 0.0377568
HSPA8 heat shock 70kDa protein 8 0.0373765
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0365937
ENO1 enolase 1, (alpha) 0.0354461
GASK1B golgi associated kinase 1B 0.0353553
GJA1 gap junction protein, alpha 1, 43kDa 0.0353079
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0350243
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0349135
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.034907
SPAG9 sperm associated antigen 9 0.0347583
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0346927
PUM2 pumilio RNA-binding family member 2 0.0346784
CEP192 centrosomal protein 192kDa 0.0346405
ADAM17 ADAM metallopeptidase domain 17 0.0344585
TNPO1 transportin 1 0.0342747
OXR1 oxidation resistance 1 0.0335782
ETNK1 ethanolamine kinase 1 0.0329292
EPHA6 EPH receptor A6 0.0323553
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0316962
EIF4A1 eukaryotic translation initiation factor 4A1 0.0312855
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0311283
CEP95 centrosomal protein 95kDa 0.0309498
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0304977
WRN Werner syndrome, RecQ helicase-like 0.030478
MARCHF6 membrane associated ring-CH-type finger 6 0.0302097
GSK3B glycogen synthase kinase 3 beta 0.0299534
USP9X ubiquitin specific peptidase 9, X-linked 0.0299454
CKAP5 cytoskeleton associated protein 5 0.0296174
GPBP1 GC-rich promoter binding protein 1 0.0293436
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0288096
PDE4B phosphodiesterase 4B, cAMP-specific 0.0287829
WDR43 WD repeat domain 43 0.0287708
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286332
ADGRG6 adhesion G protein-coupled receptor G6 0.0284353
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0283377
AXIN2 axin 2 0.0282605
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0281811
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0279625
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0278848
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0276291
HDLBP high density lipoprotein binding protein 0.0269519
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0268113
MATR3 matrin 3 0.0267712
MDN1 MDN1, midasin homolog (yeast) 0.0266795
THOC1 THO complex 1 0.0265679
APP amyloid beta (A4) precursor protein 0.0263729
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0263666
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0261509
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0256136
MTAP methylthioadenosine phosphorylase 0.0254621
BRD2 bromodomain containing 2 0.0254577
KLHL24 kelch-like family member 24 0.0254235
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0253992
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0253916
CHD1 chromodomain helicase DNA binding protein 1 0.0251583
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0250794
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0242495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0241498
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0238452
BRWD1 bromodomain and WD repeat domain containing 1 0.0236372
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0235598

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.146058
TMSB10 thymosin beta 10 -0.0794914
EGR1 early growth response 1 -0.0695972
PTMA prothymosin, alpha -0.0632657
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.061981
VIM vimentin -0.0592106
ANKRD12 ankyrin repeat domain 12 -0.0565734
RAB7A RAB7A, member RAS oncogene family -0.0554226
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0516293
EHBP1 EH domain binding protein 1 -0.0510153
ACTG1 actin gamma 1 -0.0504262
RPL35A ribosomal protein L35a -0.046707
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0456831
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0446245
RPS19 ribosomal protein S19 -0.0432949
RPS6 ribosomal protein S6 -0.0417625
TPT1 tumor protein, translationally-controlled 1 -0.0417301
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0405577
LOC102724023 ES1 protein homolog, mitochondrial -0.0400829
RPS8 ribosomal protein S8 -0.0394155
NHSL1 NHS-like 1 -0.0381266
RPL37A ribosomal protein L37a -0.0374998
DST dystonin -0.0372631
RPLP2 ribosomal protein, large, P2 -0.036295
FTL ferritin, light polypeptide -0.03514
RPLP1 ribosomal protein, large, P1 -0.0328769
KLF6 Kruppel-like factor 6 -0.0327801
JMJD1C jumonji domain containing 1C -0.0315205
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0310464
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304462
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0297491
DDIT3 DNA-damage-inducible transcript 3 -0.0286485
CUX1 cut-like homeobox 1 -0.027352
BABAM2 BRISC and BRCA1 A complex member 2 -0.0270591
DPYD dihydropyrimidine dehydrogenase -0.0265923
CSMD3 CUB and Sushi multiple domains 3 -0.026345
RPS23 ribosomal protein S23 -0.0262518
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0261887
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.025746
MACF1 microtubule-actin crosslinking factor 1 -0.0256114
TPM4 tropomyosin 4 -0.0253899
CNRIP1 cannabinoid receptor interacting protein 1 -0.0252079
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0247844
HMGA2 high mobility group AT-hook 2 -0.0245777
RAD51B RAD51 paralog B -0.0242955
RASAL2 RAS protein activator like 2 -0.0242563
RPS29 ribosomal protein S29 -0.024015
RIMS2 regulating synaptic membrane exocytosis 2 -0.0240115
RPS13 ribosomal protein S13 -0.0240056
DTNA dystrobrevin, alpha -0.0239495
RPS12 ribosomal protein S12 -0.0234659
LRRC23 leucine rich repeat containing 23 -0.022873
RPL36 ribosomal protein L36 -0.0227044
NAV3 neuron navigator 3 -0.0225427
KSR2 kinase suppressor of ras 2 -0.0221545
RPL34 ribosomal protein L34 -0.022116
S100A9 S100 calcium binding protein A9 -0.0210523
R3HDM2 R3H domain containing 2 -0.0207776
RPS27 ribosomal protein S27 -0.0205678
KPNB1 karyopherin (importin) beta 1 -0.0203972
RPL9 ribosomal protein L9 -0.020155
GNAS GNAS complex locus -0.0201062
S100A10 S100 calcium binding protein A10 -0.0197193
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0194892
PFN1 profilin 1 -0.0194016
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0193201
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0192162
MYL12B myosin, light chain 12B, regulatory -0.0190482
ANK2 ankyrin 2, neuronal -0.0189931
MYADM myeloid-associated differentiation marker -0.0189714
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0189652
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.018922
PHACTR4 phosphatase and actin regulator 4 -0.018827
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0187037
THSD4 thrombospondin, type I, domain containing 4 -0.0186685
MSRB3 methionine sulfoxide reductase B3 -0.0185583
RPL37 ribosomal protein L37 -0.0183667
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0182983
PRR16 proline rich 16 -0.0182564
RPS10 ribosomal protein S10 -0.0181634
SSH2 slingshot protein phosphatase 2 -0.018059
AFF4 AF4/FMR2 family, member 4 -0.0177469
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.017654
MAP1B microtubule-associated protein 1B -0.0173905
RPL12 ribosomal protein L12 -0.0173295
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0171176
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0169799
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168013
LRMDA leucine rich melanocyte differentiation associated -0.0167083
RPL31 ribosomal protein L31 -0.0166878
HMGA1 high mobility group AT-hook 1 -0.0161766
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0159409
HMGB1 high mobility group box 1 -0.0158357
RPS14 ribosomal protein S14 -0.0156596
INTS6 integrator complex subunit 6 -0.015537
PDE4D phosphodiesterase 4D, cAMP-specific -0.0154741
TUBA1B tubulin, alpha 1b -0.0154734
RPL36A ribosomal protein L36a -0.0152965
NEBL nebulette -0.0152764
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0152009