| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.212411 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.198779 |
| COL6A3 | collagen, type VI, alpha 3 | 0.171922 |
| ENO1 | enolase 1, (alpha) | 0.141106 |
| STC1 | stanniocalcin 1 | 0.139636 |
| MT2A | metallothionein 2A | 0.131794 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.129851 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.119041 |
| NDRG1 | N-myc downstream regulated 1 | 0.117389 |
| CD44 | CD44 molecule (Indian blood group) | 0.0966184 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0955835 |
| VEGFA | vascular endothelial growth factor A | 0.0917699 |
| CALU | calumenin | 0.0860117 |
| ATP13A3 | ATPase type 13A3 | 0.0848209 |
| UBC | ubiquitin C | 0.0801122 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0770865 |
| INHBA | inhibin, beta A | 0.0762413 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0722564 |
| GOLGA4 | golgin A4 | 0.0720106 |
| CDH13 | cadherin 13 | 0.0681915 |
| TMSB10 | thymosin beta 10 | 0.0659038 |
| NAV2 | neuron navigator 2 | 0.0643158 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0601478 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0598434 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0585254 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0562379 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0559289 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0547019 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0543443 |
| VIM | vimentin | 0.0528188 |
| SMAD3 | SMAD family member 3 | 0.0488928 |
| PTMA | prothymosin, alpha | 0.0473544 |
| SPAG9 | sperm associated antigen 9 | 0.0446983 |
| PTK2 | protein tyrosine kinase 2 | 0.0440928 |
| LDHA | lactate dehydrogenase A | 0.0440621 |
| JUN | jun proto-oncogene | 0.043383 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0432302 |
| EGFR | epidermal growth factor receptor | 0.04321 |
| LOXL2 | lysyl oxidase-like 2 | 0.0423146 |
| COG5 | component of oligomeric golgi complex 5 | 0.0410902 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0409596 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0395919 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0395617 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0394136 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0387841 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0382255 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0381852 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.038152 |
| ANLN | anillin, actin binding protein | 0.0373498 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.037346 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0372273 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0370956 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0367526 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0363422 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.035519 |
| AHNAK | AHNAK nucleoprotein | 0.0355042 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0352721 |
| CENPF | centromere protein F, 350/400kDa | 0.0352526 |
| FNIP1 | folliculin interacting protein 1 | 0.0351367 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0351026 |
| HMGA2 | high mobility group AT-hook 2 | 0.0346836 |
| APP | amyloid beta (A4) precursor protein | 0.0345999 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.034589 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0340568 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0339977 |
| FBN1 | fibrillin 1 | 0.0338031 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0336104 |
| TPX2 | TPX2, microtubule-associated | 0.0331405 |
| RPS27A | ribosomal protein S27a | 0.032561 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0325012 |
| CENPE | centromere protein E, 312kDa | 0.0324834 |
| IER3 | immediate early response 3 | 0.0321719 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0320583 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0319913 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0319824 |
| MKI67 | marker of proliferation Ki-67 | 0.0319389 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0317282 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0313438 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0312366 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.030944 |
| ARRDC3 | arrestin domain containing 3 | 0.0304342 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0301916 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.030143 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0291604 |
| NGLY1 | N-glycanase 1 | 0.0288735 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0287836 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0285331 |
| PKM | pyruvate kinase, muscle | 0.0284815 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0281858 |
| ACTN4 | actinin, alpha 4 | 0.0281808 |
| FLOT1 | flotillin 1 | 0.0276661 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0276646 |
| CALR | calreticulin | 0.0274256 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0270748 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0269594 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.026832 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0264888 |
| OGA | O-GlcNAcase | 0.0262912 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0262158 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0262104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.136025 |
| FN1 | fibronectin 1 | -0.116956 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0674136 |
| RIGI | RNA sensor RIG-I | -0.0395442 |
| VCL | vinculin | -0.038117 |
| GLIS3 | GLIS family zinc finger 3 | -0.0347881 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0316565 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0310678 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0310331 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0303918 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.030175 |
| PALLD | palladin, cytoskeletal associated protein | -0.0299654 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.029955 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0294606 |
| VCAN | versican | -0.0281206 |
| CALD1 | caldesmon 1 | -0.027134 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0268732 |
| IL6ST | interleukin 6 signal transducer | -0.026532 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0263847 |
| NREP | neuronal regeneration related protein | -0.0259107 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0258411 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0254674 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0252743 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0239484 |
| EGR1 | early growth response 1 | -0.0233593 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0218925 |
| JAG1 | jagged 1 | -0.0211425 |
| SVIL | supervillin | -0.0205943 |
| POSTN | periostin, osteoblast specific factor | -0.0198514 |
| CADM1 | cell adhesion molecule 1 | -0.0197298 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0196843 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0193142 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0186094 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0184185 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0181232 |
| SP100 | SP100 nuclear antigen | -0.0176703 |
| PDLIM5 | PDZ and LIM domain 5 | -0.017646 |
| EBF1 | early B-cell factor 1 | -0.0158722 |
| JAZF1 | JAZF zinc finger 1 | -0.0153734 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.015346 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0151107 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0148964 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0147809 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0147092 |
| MACROD2 | MACRO domain containing 2 | -0.0145388 |
| KLF12 | Kruppel-like factor 12 | -0.0143788 |
| EPHB1 | EPH receptor B1 | -0.0142082 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0140376 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0139636 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0139199 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0138457 |
| IGSF1 | immunoglobulin superfamily, member 1 | -0.0135026 |
| MAP1B | microtubule-associated protein 1B | -0.0133882 |
| PRSS23 | protease, serine, 23 | -0.0133873 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0133701 |
| ZNF804A | zinc finger protein 804A | -0.0132732 |
| HIP1 | huntingtin interacting protein 1 | -0.013241 |
| CFB | complement factor B | -0.0128156 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0128138 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0126958 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0126696 |
| CNTN5 | contactin 5 | -0.0126506 |
| FRMD5 | FERM domain containing 5 | -0.0126006 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.0125378 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0123404 |
| INSIG1 | insulin induced gene 1 | -0.0121368 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0120269 |
| LIPG | lipase, endothelial | -0.0119168 |
| SUMF1 | sulfatase modifying factor 1 | -0.0119117 |
| RAD51B | RAD51 paralog B | -0.0115384 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.0115128 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0114611 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0114171 |
| GPC6 | glypican 6 | -0.0113986 |
| BNC2 | basonuclin 2 | -0.0113651 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0112407 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0112222 |
| WWOX | WW domain containing oxidoreductase | -0.0111963 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0111655 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0111317 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0111221 |
| PCDH7 | protocadherin 7 | -0.0111206 |
| RORA | RAR-related orphan receptor A | -0.0110793 |
| VEGFC | vascular endothelial growth factor C | -0.0107519 |
| SULF1 | sulfatase 1 | -0.0106656 |
| KIAA1217 | KIAA1217 | -0.0105712 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0105232 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0104377 |
| PLSCR1 | phospholipid scramblase 1 | -0.0103884 |
| LIMA1 | LIM domain and actin binding 1 | -0.0103472 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0103283 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0102645 |
| PTX3 | pentraxin 3, long | -0.0102364 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0102266 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.010166 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0101648 |
| MLF1 | myeloid leukemia factor 1 | -0.0100759 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.010055 |
| KALRN | kalirin, RhoGEF kinase | -0.00984575 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00983326 |
