Digitoxin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.237656
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.165986
SAMD4A sterile alpha motif domain containing 4A 0.139241
SLC38A2 solute carrier family 38, member 2 0.124164
EHBP1 EH domain binding protein 1 0.122794
FNDC3B fibronectin type III domain containing 3B 0.122761
ENO1 enolase 1, (alpha) 0.114615
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0998272
ASPH aspartate beta-hydroxylase 0.0978489
FRMD5 FERM domain containing 5 0.0956928
MAML2 mastermind-like 2 (Drosophila) 0.0838347
FAT1 FAT atypical cadherin 1 0.0788251
ATXN1 ataxin 1 0.0782913
GMDS GDP-mannose 4,6-dehydratase 0.0776265
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0750369
DSPP dentin sialophosphoprotein 0.0733032
UBC ubiquitin C 0.0714667
NPAS2 neuronal PAS domain protein 2 0.0713237
SVIL supervillin 0.0668189
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0640943
DST dystonin 0.0623206
FLNB filamin B, beta 0.0611177
FN1 fibronectin 1 0.0561674
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0558426
MBNL2 muscleblind-like splicing regulator 2 0.0531532
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0519248
EEF2 eukaryotic translation elongation factor 2 0.0483319
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0463971
AFDN afadin, adherens junction formation factor 0.0462219
VMP1 vacuole membrane protein 1 0.0454112
FAM135A family with sequence similarity 135, member A 0.0454002
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0453147
SMAD3 SMAD family member 3 0.0452209
TRIO trio Rho guanine nucleotide exchange factor 0.0450096
DOCK5 dedicator of cytokinesis 5 0.0438841
BCL2L1 BCL2-like 1 0.0433737
OSBPL10 oxysterol binding protein-like 10 0.0428534
ELL2 elongation factor, RNA polymerase II, 2 0.0422973
ITCH itchy E3 ubiquitin protein ligase 0.0411878
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0404477
APLP2 amyloid beta (A4) precursor-like protein 2 0.0401912
FMNL2 formin-like 2 0.0400197
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0393251
AHR aryl hydrocarbon receptor 0.0393195
GPC6 glypican 6 0.0384818
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0381018
RPS27A ribosomal protein S27a 0.0376874
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0374761
TPM4 tropomyosin 4 0.0366107
LRMDA leucine rich melanocyte differentiation associated 0.036387
PARD3 par-3 family cell polarity regulator 0.0363568
PCBP2 poly(rC) binding protein 2 0.0357873
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.03575
ITGAV integrin, alpha V 0.0353228
SESTD1 SEC14 and spectrin domains 1 0.0348048
HSPA1A heat shock 70kDa protein 1A 0.0343986
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0343702
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0343377
MCL1 myeloid cell leukemia 1 0.0342645
UBASH3B ubiquitin associated and SH3 domain containing B 0.0340018
ARHGAP9 Rho GTPase activating protein 9 0.0339768
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0336904
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0334271
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0330986
ACSL5 acyl-CoA synthetase long-chain family member 5 0.032898
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0327657
MBNL1 muscleblind-like splicing regulator 1 0.0327557
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0321352
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0314349
JAG1 jagged 1 0.0314305
DLC1 DLC1 Rho GTPase activating protein 0.0308789
FAM107B family with sequence similarity 107, member B 0.0308202
MYH9 myosin, heavy chain 9, non-muscle 0.0301274
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0301043
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0295969
LPP LIM domain containing preferred translocation partner in lipoma 0.0294919
ARHGAP21 Rho GTPase activating protein 21 0.0294432
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0294281
STK39 serine threonine kinase 39 0.0294203
C3 complement component 3 0.0291226
KYNU kynureninase 0.0287817
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0285892
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0280906
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0278449
ADAM9 ADAM metallopeptidase domain 9 0.0277173
KIZ kizuna centrosomal protein 0.0274805
RNASET2 ribonuclease T2 0.027268
OSMR oncostatin M receptor 0.0272475
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0271622
FNDC3A fibronectin type III domain containing 3A 0.0270285
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0262106
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0261988
ZMYND8 zinc finger, MYND-type containing 8 0.0261023
PKM pyruvate kinase, muscle 0.0259892
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0259788
RAB3B RAB3B, member RAS oncogene family 0.0258309
TBC1D22A TBC1 domain family, member 22A 0.0258188
ABAT 4-aminobutyrate aminotransferase 0.0256355
ZBTB20 zinc finger and BTB domain containing 20 0.025416
PDLIM5 PDZ and LIM domain 5 0.0253074

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.162192
FBF1 Fas (TNFRSF6) binding factor 1 -0.114461
TPT1 tumor protein, translationally-controlled 1 -0.0520508
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0511414
IGF2 insulin-like growth factor 2 -0.0506793
MT2A metallothionein 2A -0.0474139
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0465184
RPL11 ribosomal protein L11 -0.0463796
APOA2 apolipoprotein A-II -0.0425284
DDIT4 DNA-damage-inducible transcript 4 -0.0402146
APOB apolipoprotein B -0.0371783
IGFBP1 insulin-like growth factor binding protein 1 -0.0369396
FTL ferritin, light polypeptide -0.0355664
RPLP0 ribosomal protein, large, P0 -0.0318506
AHSG alpha-2-HS-glycoprotein -0.031769
RPL35A ribosomal protein L35a -0.0295465
RPS6 ribosomal protein S6 -0.0281805
RPS8 ribosomal protein S8 -0.0272924
GDF15 growth differentiation factor 15 -0.0272044
IER3 immediate early response 3 -0.0255188
RPL34 ribosomal protein L34 -0.0253699
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0248005
RPS24 ribosomal protein S24 -0.024297
RPL12 ribosomal protein L12 -0.0241479
APOA1 apolipoprotein A-I -0.02391
A2M alpha-2-macroglobulin -0.0230253
RPLP1 ribosomal protein, large, P1 -0.0226877
BHLHE40 basic helix-loop-helix family, member e40 -0.0226848
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0212542
RRBP1 ribosome binding protein 1 -0.0211037
GNAS GNAS complex locus -0.0206813
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0204316
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0197945
GPC3 glypican 3 -0.0196568
EIF1 eukaryotic translation initiation factor 1 -0.0193531
ADM adrenomedullin -0.0192425
AMBP alpha-1-microglobulin/bikunin precursor -0.0184212
ARF1 ADP-ribosylation factor 1 -0.017499
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0173498
RPS19 ribosomal protein S19 -0.0173141
RYBP RING1 and YY1 binding protein -0.0165043
SELENOP selenoprotein P -0.0163424
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0162717
FABP1 fatty acid binding protein 1, liver -0.0160852
RACK1 receptor for activated C kinase 1 -0.0160251
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0159371
RPS21 ribosomal protein S21 -0.015135
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0151199
RPS2 ribosomal protein S2 -0.015065
RPS16 ribosomal protein S16 -0.0148858
RPS20 ribosomal protein S20 -0.0148283
KLF6 Kruppel-like factor 6 -0.0145862
NIPBL Nipped-B homolog (Drosophila) -0.0145154
RPL27A ribosomal protein L27a -0.0142916
RPL28 ribosomal protein L28 -0.0142844
KDM5B lysine (K)-specific demethylase 5B -0.0141352
AGXT alanine-glyoxylate aminotransferase -0.0137728
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0137075
RPL13A ribosomal protein L13a -0.0135788
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0134595
RPS25 ribosomal protein S25 -0.0133364
PHF21A PHD finger protein 21A -0.0132683
RPL8 ribosomal protein L8 -0.0130916
TRIM26 tripartite motif containing 26 -0.0129234
TXNIP thioredoxin interacting protein -0.0126397
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0125789
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0123168
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0122188
RPS23 ribosomal protein S23 -0.0122012
B2M beta-2-microglobulin -0.0121123
RPL19 ribosomal protein L19 -0.0120102
APOC1 apolipoprotein C-I -0.0119184
RPL32 ribosomal protein L32 -0.0112104
RPL7 ribosomal protein L7 -0.0110922
MIMS1 mitochondrial inner membrane scaffold 1 -0.0110175
RPL38 ribosomal protein L38 -0.0109727
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0109318
TFRC transferrin receptor -0.0108651
MARCKS myristoylated alanine-rich protein kinase C substrate -0.010642
STAU1 staufen double-stranded RNA binding protein 1 -0.0105664
LOC102724023 ES1 protein homolog, mitochondrial -0.0104466
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0104308
RPL31 ribosomal protein L31 -0.0103067
DUSP12 dual specificity phosphatase 12 -0.0102486
FTH1 ferritin, heavy polypeptide 1 -0.0102473
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0102248
ZFR zinc finger RNA binding protein -0.0102205
BTG1 B-cell translocation gene 1, anti-proliferative -0.0101827
FGG fibrinogen gamma chain -0.0101453
RBP4 retinol binding protein 4, plasma -0.0100305
TNRC6B trinucleotide repeat containing 6B -0.00995124
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.00981447
PHF3 PHD finger protein 3 -0.00979734
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00978018
SDC4 syndecan 4 -0.00953244
RPL37 ribosomal protein L37 -0.00947436
SBF2 SET binding factor 2 -0.00938127
WDR45B WD repeat domain 45B -0.00937377
ISG15 ISG15 ubiquitin-like modifier -0.00936749
RPL30 ribosomal protein L30 -0.00935338