| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.321873 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.274949 |
| NPSR1 | neuropeptide S receptor 1 | 0.137124 |
| UBC | ubiquitin C | 0.0719763 |
| PTMA | prothymosin, alpha | 0.0666421 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0607316 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0587044 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0558347 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0541156 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0538982 |
| AHR | aryl hydrocarbon receptor | 0.0455507 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0447705 |
| KRT8 | keratin 8, type II | 0.0433066 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0430508 |
| POTEF | POTE ankyrin domain family, member F | 0.0417783 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.040971 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0409574 |
| TMSB10 | thymosin beta 10 | 0.0408166 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0372786 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0370122 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0363361 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0359152 |
| ANLN | anillin, actin binding protein | 0.0353004 |
| RBM39 | RNA binding motif protein 39 | 0.0346242 |
| PCBP2 | poly(rC) binding protein 2 | 0.0344462 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0341025 |
| ZNF207 | zinc finger protein 207 | 0.033439 |
| MGAM2 | maltase-glucoamylase 2 (putative) | 0.0330847 |
| GOLGA4 | golgin A4 | 0.0328304 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0326423 |
| RLF | rearranged L-myc fusion | 0.0324579 |
| TRIM31 | tripartite motif containing 31 | 0.0320018 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0312889 |
| KRT17 | keratin 17, type I | 0.0312849 |
| SIK3 | SIK family kinase 3 | 0.0308008 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0305702 |
| POF1B | premature ovarian failure, 1B | 0.0298455 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0298452 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0297894 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0297622 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0296629 |
| FLNB | filamin B, beta | 0.0295569 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0294279 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0293368 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0289798 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0286846 |
| VMP1 | vacuole membrane protein 1 | 0.0284044 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0281585 |
| CCNL1 | cyclin L1 | 0.0280857 |
| CALU | calumenin | 0.0278969 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0275509 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0274886 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0274467 |
| FAT1 | FAT atypical cadherin 1 | 0.0269094 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0265234 |
| FAM135A | family with sequence similarity 135, member A | 0.0263174 |
| DSPP | dentin sialophosphoprotein | 0.0262161 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0259173 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0258979 |
| NBAS | neuroblastoma amplified sequence | 0.0258886 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0252431 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.025203 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0251418 |
| RPS27A | ribosomal protein S27a | 0.0251379 |
| SHROOM3 | shroom family member 3 | 0.0249976 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0249382 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0247388 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0244903 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0244861 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0244255 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0244121 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0242164 |
| TOP1 | topoisomerase (DNA) I | 0.0238278 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0238138 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.023686 |
| ACTN4 | actinin, alpha 4 | 0.023652 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0232689 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0230704 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0229984 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0229724 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0228663 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0227516 |
| CALR | calreticulin | 0.0226929 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.022156 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0220709 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0218426 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0216474 |
| ENO1 | enolase 1, (alpha) | 0.0216332 |
| PAPOLA | poly(A) polymerase alpha | 0.021389 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.021211 |
| BRD2 | bromodomain containing 2 | 0.0208667 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0208383 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0208083 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0207488 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0205481 |
| ANXA3 | annexin A3 | 0.0203791 |
| TXNRD1 | thioredoxin reductase 1 | 0.0203414 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0202572 |
| ETNK1 | ethanolamine kinase 1 | 0.020191 |
| PTK2 | protein tyrosine kinase 2 | 0.020116 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.0656634 |
| RPL35A | ribosomal protein L35a | -0.0440704 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0431664 |
| NDRG1 | N-myc downstream regulated 1 | -0.0398012 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0388058 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.038138 |
| RPS6 | ribosomal protein S6 | -0.0356103 |
| ITGA6 | integrin, alpha 6 | -0.0340256 |
| LCN2 | lipocalin 2 | -0.0323212 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0315367 |
| S100A10 | S100 calcium binding protein A10 | -0.0314918 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0310557 |
| TMSB4X | thymosin beta 4, X-linked | -0.026467 |
| AGR2 | anterior gradient 2 | -0.0238224 |
| MMP1 | matrix metallopeptidase 1 | -0.0232413 |
| ASPH | aspartate beta-hydroxylase | -0.0232068 |
| RPL19 | ribosomal protein L19 | -0.0223991 |
| RPS25 | ribosomal protein S25 | -0.0221215 |
| SLC38A1 | solute carrier family 38, member 1 | -0.021245 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0207026 |
| S100A11 | S100 calcium binding protein A11 | -0.0206496 |
| H1-0 | H1.0 linker histone | -0.0202277 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0200058 |
| PGK1 | phosphoglycerate kinase 1 | -0.0192726 |
| RPLP0 | ribosomal protein, large, P0 | -0.0189048 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0187675 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0185742 |
| HLA-C | major histocompatibility complex, class I, C | -0.0184229 |
| JUN | jun proto-oncogene | -0.0181964 |
| SNX9 | sorting nexin 9 | -0.01816 |
| TFRC | transferrin receptor | -0.0178846 |
| FTL | ferritin, light polypeptide | -0.0175171 |
| S100P | S100 calcium binding protein P | -0.0174642 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0170817 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0170419 |
| AGR3 | anterior gradient 3 | -0.0168094 |
| DST | dystonin | -0.0167936 |
| RPS8 | ribosomal protein S8 | -0.0164544 |
| TXNIP | thioredoxin interacting protein | -0.0161978 |
| RPL38 | ribosomal protein L38 | -0.016186 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0161385 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0153712 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0153626 |
| RPS2 | ribosomal protein S2 | -0.0153485 |
| RPL11 | ribosomal protein L11 | -0.015129 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0144655 |
| S100A6 | S100 calcium binding protein A6 | -0.0143481 |
| HLA-A | major histocompatibility complex, class I, A | -0.0142437 |
| RPL34 | ribosomal protein L34 | -0.0140761 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0139915 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0138039 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0133731 |
| CUX1 | cut-like homeobox 1 | -0.0132066 |
| CD63 | CD63 molecule | -0.0130864 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0130167 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0129135 |
| EXPH5 | exophilin 5 | -0.0128071 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0127863 |
| ARF1 | ADP-ribosylation factor 1 | -0.0127318 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0126764 |
| RPS29 | ribosomal protein S29 | -0.012251 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0122111 |
| RPL30 | ribosomal protein L30 | -0.0121571 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -0.0121229 |
| EGFR | epidermal growth factor receptor | -0.0120027 |
| H3-3B | H3.3 histone B | -0.0119909 |
| RNASET2 | ribonuclease T2 | -0.0119395 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0119067 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0118212 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0117051 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0116626 |
| SEC61G | Sec61 gamma subunit | -0.0116583 |
| AREG | amphiregulin | -0.0116526 |
| RPS19 | ribosomal protein S19 | -0.0115113 |
| CCND1 | cyclin D1 | -0.0113876 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0113374 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0113311 |
| DUSP6 | dual specificity phosphatase 6 | -0.0112925 |
| ZFHX3 | zinc finger homeobox 3 | -0.0112001 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0111804 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0110968 |
| WWOX | WW domain containing oxidoreductase | -0.0110197 |
| HLA-E | major histocompatibility complex, class I, E | -0.0110156 |
| RAD51B | RAD51 paralog B | -0.0109975 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0109692 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0108769 |
| RPL32 | ribosomal protein L32 | -0.0107844 |
| ATF5 | activating transcription factor 5 | -0.0107814 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0107457 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0105191 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0105118 |
| JMJD1C | jumonji domain containing 1C | -0.0104894 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0103548 |
| NOP56 | NOP56 ribonucleoprotein | -0.0103319 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0103185 |
| RPS20 | ribosomal protein S20 | -0.0102731 |
| RPS24 | ribosomal protein S24 | -0.0101705 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0101425 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.01006 |
| RPLP1 | ribosomal protein, large, P1 | -0.00997833 |
