Digitoxin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.145834
EREG epiregulin 0.123378
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.114301
DSCAM Down syndrome cell adhesion molecule 0.0873503
FAT1 FAT atypical cadherin 1 0.0834894
GOLGA4 golgin A4 0.0820234
LMO7 LIM domain 7 0.0788607
PDIA4 protein disulfide isomerase family A, member 4 0.070597
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0692533
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0647164
MED13L mediator complex subunit 13-like 0.0597058
ZFAND3 zinc finger, AN1-type domain 3 0.0596082
RNF145 ring finger protein 145 0.0593479
EEF2 eukaryotic translation elongation factor 2 0.0572802
OGA O-GlcNAcase 0.0570399
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0555411
UBC ubiquitin C 0.0550155
CANX calnexin 0.0517518
HDLBP high density lipoprotein binding protein 0.0510068
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0501584
SPAG9 sperm associated antigen 9 0.0493963
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0493718
SEC31A SEC31 homolog A (S. cerevisiae) 0.0479411
KDM3A lysine (K)-specific demethylase 3A 0.0470831
RNF43 ring finger protein 43 0.0460952
ENO1 enolase 1, (alpha) 0.0460371
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0431369
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0429777
CALR calreticulin 0.0425525
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0424533
ZFC3H1 zinc finger, C3H1-type containing 0.0419447
PKM pyruvate kinase, muscle 0.0414619
AFDN afadin, adherens junction formation factor 0.0414209
SLC38A2 solute carrier family 38, member 2 0.0409683
COG5 component of oligomeric golgi complex 5 0.040648
NBAS neuroblastoma amplified sequence 0.040645
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0402594
USP34 ubiquitin specific peptidase 34 0.0397503
FRYL FRY-like 0.0393292
GSK3B glycogen synthase kinase 3 beta 0.0392291
RAB1A RAB1A, member RAS oncogene family 0.038979
MBNL2 muscleblind-like splicing regulator 2 0.0387915
WAC WW domain containing adaptor with coiled-coil 0.0387102
GDF15 growth differentiation factor 15 0.0380139
MARCHF6 membrane associated ring-CH-type finger 6 0.0373115
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0368429
FAM13A family with sequence similarity 13, member A 0.0365888
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.036336
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0362776
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0361392
CCNY cyclin Y 0.0361305
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0360978
CD2AP CD2-associated protein 0.0358694
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0355162
LDHA lactate dehydrogenase A 0.0354302
BIRC6 baculoviral IAP repeat containing 6 0.0349511
KITLG KIT ligand 0.0348155
ZC3H11A zinc finger CCCH-type containing 11A 0.0347008
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0342921
UBA6 ubiquitin-like modifier activating enzyme 6 0.0342871
MYO5B myosin VB 0.0340641
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0338733
WDR45B WD repeat domain 45B 0.0331121
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.033072
COPB1 coatomer protein complex, subunit beta 1 0.03285
COPA coatomer protein complex, subunit alpha 0.0328043
SRP54 signal recognition particle 54kDa 0.0327175
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0322377
SUCO SUN domain containing ossification factor 0.0322289
TM9SF3 transmembrane 9 superfamily member 3 0.0322196
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.03216
RBM39 RNA binding motif protein 39 0.0319899
MARK3 MAP/microtubule affinity-regulating kinase 3 0.031733
PNISR PNN-interacting serine/arginine-rich protein 0.0313738
CEMIP2 cell migration inducing hyaluronidase 2 0.0312224
EHF ets homologous factor 0.0310917
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0306067
NIPBL Nipped-B homolog (Drosophila) 0.0305558
XPOT exportin, tRNA 0.0303971
TFG TRK-fused gene 0.0301744
ZMYM2 zinc finger, MYM-type 2 0.0301015
ADAM17 ADAM metallopeptidase domain 17 0.0299173
TXNIP thioredoxin interacting protein 0.0297947
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0297706
EPS8 epidermal growth factor receptor pathway substrate 8 0.0297206
CLTC clathrin, heavy chain (Hc) 0.0296387
ESRP1 epithelial splicing regulatory protein 1 0.0295185
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0292266
DERA deoxyribose-phosphate aldolase (putative) 0.028933
KDM6A lysine (K)-specific demethylase 6A 0.0288086
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0287905
BBX bobby sox homolog (Drosophila) 0.0286911
PRRC2C proline-rich coiled-coil 2C 0.028661
MAP2K4 mitogen-activated protein kinase kinase 4 0.0285491
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0284191
GRB10 growth factor receptor-bound protein 10 0.0282674
PDIA6 protein disulfide isomerase family A, member 6 0.0280853
PRRC1 proline-rich coiled-coil 1 0.0280742
EXOC1 exocyst complex component 1 0.0277465
GIGYF2 GRB10 interacting GYF protein 2 0.0276071

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.228936
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.120347
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.109007
NALF1 NALCN channel auxiliary factor 1 -0.10687
RPS6 ribosomal protein S6 -0.100595
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0867806
TMSB10 thymosin beta 10 -0.0817307
TPT1 tumor protein, translationally-controlled 1 -0.0718489
ACTG1 actin gamma 1 -0.0666312
ALCAM activated leukocyte cell adhesion molecule -0.0655473
MYO1E myosin IE -0.0653149
LOC102724023 ES1 protein homolog, mitochondrial -0.0630429
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0624281
VCL vinculin -0.0598291
FHIT fragile histidine triad -0.0575638
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0545159
ONECUT3 one cut homeobox 3 -0.0541675
RPL35A ribosomal protein L35a -0.0540237
GMDS GDP-mannose 4,6-dehydratase -0.0498873
RAD51B RAD51 paralog B -0.0498765
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0466889
RPS19 ribosomal protein S19 -0.0462945
PDE4D phosphodiesterase 4D, cAMP-specific -0.0461721
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0451868
CEMIP cell migration inducing protein, hyaluronan binding -0.0451363
RPS8 ribosomal protein S8 -0.0449745
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0432649
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.042441
GREB1L growth regulation by estrogen in breast cancer-like -0.0423906
PSD3 pleckstrin and Sec7 domain containing 3 -0.0420781
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0412307
TNS4 tensin 4 -0.040889
GPHN gephyrin -0.0401487
ANTXR2 anthrax toxin receptor 2 -0.0393556
SOX4 SRY (sex determining region Y)-box 4 -0.0377818
S100A6 S100 calcium binding protein A6 -0.0376536
TUBB4B tubulin, beta 4B class IVb -0.0366056
POTEF POTE ankyrin domain family, member F -0.0353655
TFF3 trefoil factor 3 (intestinal) -0.0344221
MAML2 mastermind-like 2 (Drosophila) -0.0342853
KRT18 keratin 18, type I -0.0342239
PTMA prothymosin, alpha -0.0340948
KRT19 keratin 19, type I -0.0340742
TPM4 tropomyosin 4 -0.0338698
LAMA4 laminin, alpha 4 -0.0335659
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0335178
CCSER1 coiled-coil serine-rich protein 1 -0.0328454
RPLP1 ribosomal protein, large, P1 -0.0325347
SMYD3 SET and MYND domain containing 3 -0.0325045
RPLP2 ribosomal protein, large, P2 -0.0324619
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0320758
RNF217 ring finger protein 217 -0.0319745
EGR1 early growth response 1 -0.0317903
SLC35F3 solute carrier family 35, member F3 -0.0314375
KLF6 Kruppel-like factor 6 -0.0310955
JUN jun proto-oncogene -0.0310308
TFF1 trefoil factor 1 -0.0305199
CCND1 cyclin D1 -0.030011
RIN2 Ras and Rab interactor 2 -0.0294754
S100A9 S100 calcium binding protein A9 -0.0294479
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0294393
FOSL1 FOS-like antigen 1 -0.0294163
HMGA1 high mobility group AT-hook 1 -0.0293136
RPL34 ribosomal protein L34 -0.0288323
RPS25 ribosomal protein S25 -0.0286604
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0275907
RPL9 ribosomal protein L9 -0.0275384
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0275375
RPS21 ribosomal protein S21 -0.0271079
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0270693
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.026885
SH3D19 SH3 domain containing 19 -0.0268262
ZBTB20 zinc finger and BTB domain containing 20 -0.0266766
PFN1 profilin 1 -0.0266442
CALB1 calbindin 1, 28kDa -0.0260952
FOXP1 forkhead box P1 -0.0258449
RPL36 ribosomal protein L36 -0.0254526
HMGB1 high mobility group box 1 -0.0253925
KLK10 kallikrein-related peptidase 10 -0.0253658
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0250971
FERMT1 fermitin family member 1 -0.0245135
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.024268
MAML3 mastermind-like 3 (Drosophila) -0.024147
S100A10 S100 calcium binding protein A10 -0.0241214
PRSS3 protease, serine, 3 -0.023375
EXOC4 exocyst complex component 4 -0.0232831
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0228344
MUC17 mucin 17, cell surface associated -0.022737
SAMD5 sterile alpha motif domain containing 5 -0.022699
LSAMP limbic system-associated membrane protein -0.0226743
RPL7A ribosomal protein L7a -0.0225676
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0223381
TUBA1B tubulin, alpha 1b -0.0222826
MECOM MDS1 and EVI1 complex locus -0.0221591
SERBP1 SERPINE1 mRNA binding protein 1 -0.0217849
DEK DEK proto-oncogene -0.0217123
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0216489
EHBP1 EH domain binding protein 1 -0.0213679
ITGB4 integrin, beta 4 -0.0211362
EPHB2 EPH receptor B2 -0.0210445