| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CAPRIN2 | caprin family member 2 | 0.133659 |
| PTMA | prothymosin, alpha | 0.133381 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.114226 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109573 |
| UBC | ubiquitin C | 0.105237 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.103405 |
| CENPF | centromere protein F, 350/400kDa | 0.101017 |
| ENO1 | enolase 1, (alpha) | 0.0985071 |
| MKI67 | marker of proliferation Ki-67 | 0.0920938 |
| DST | dystonin | 0.0917205 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0905584 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0831866 |
| FNIP1 | folliculin interacting protein 1 | 0.0796299 |
| POTEF | POTE ankyrin domain family, member F | 0.0779687 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0747523 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0717837 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0710792 |
| TP63 | tumor protein p63 | 0.069971 |
| RPS27A | ribosomal protein S27a | 0.066012 |
| APP | amyloid beta (A4) precursor protein | 0.064546 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0634803 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0630837 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0629108 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0625562 |
| EFNA5 | ephrin-A5 | 0.0624698 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.062361 |
| NAV2 | neuron navigator 2 | 0.0619967 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0611182 |
| FMNL2 | formin-like 2 | 0.0604402 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.058527 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.056633 |
| PDE10A | phosphodiesterase 10A | 0.0552945 |
| TNS3 | tensin 3 | 0.0550105 |
| EPHA4 | EPH receptor A4 | 0.0515522 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0510013 |
| CD44 | CD44 molecule (Indian blood group) | 0.049954 |
| TMSB10 | thymosin beta 10 | 0.0489973 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0486969 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0486851 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0484393 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0479513 |
| EREG | epiregulin | 0.0465419 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0464309 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0464076 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0450193 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0448879 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0448076 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0447103 |
| CMIP | c-Maf inducing protein | 0.0438019 |
| PUS7 | pseudouridylate synthase 7 (putative) | 0.0420927 |
| PLK2 | polo-like kinase 2 | 0.041912 |
| ATP13A3 | ATPase type 13A3 | 0.0417503 |
| JUN | jun proto-oncogene | 0.0406805 |
| MYOF | myoferlin | 0.0404662 |
| USP34 | ubiquitin specific peptidase 34 | 0.040422 |
| DNER | delta/notch-like EGF repeat containing | 0.0397 |
| EHBP1 | EH domain binding protein 1 | 0.0394011 |
| MCL1 | myeloid cell leukemia 1 | 0.0393662 |
| DENND1A | DENN/MADD domain containing 1A | 0.0389875 |
| CADM2 | cell adhesion molecule 2 | 0.0385728 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0384376 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.03836 |
| CANX | calnexin | 0.0380407 |
| SET | SET nuclear proto-oncogene | 0.0378021 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0375999 |
| ECT2 | epithelial cell transforming 2 | 0.0375945 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0372833 |
| SPAG9 | sperm associated antigen 9 | 0.0372643 |
| ANLN | anillin, actin binding protein | 0.0372053 |
| PGK1 | phosphoglycerate kinase 1 | 0.0369411 |
| PKM | pyruvate kinase, muscle | 0.0368394 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0361512 |
| TPX2 | TPX2, microtubule-associated | 0.035695 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0354638 |
| AHNAK | AHNAK nucleoprotein | 0.0350217 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.034754 |
| HMGB2 | high mobility group box 2 | 0.0343576 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0341964 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0338497 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0336035 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0335668 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0334717 |
| MOK | MOK protein kinase | 0.033322 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0332973 |
| SMAD3 | SMAD family member 3 | 0.0332566 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0332397 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0328683 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0328607 |
| CKAP5 | cytoskeleton associated protein 5 | 0.032794 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0327522 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0326572 |
| RUNX1 | runt-related transcription factor 1 | 0.0325003 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0319658 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0317366 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0315754 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0313849 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0312532 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0311839 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0311443 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0307326 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.104877 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0767659 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0612985 |
| RPL35A | ribosomal protein L35a | -0.0572608 |
| ANXA1 | annexin A1 | -0.055741 |
| RTN4 | reticulon 4 | -0.0524687 |
| TXNRD1 | thioredoxin reductase 1 | -0.0521601 |
| KLF6 | Kruppel-like factor 6 | -0.0486197 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0485072 |
| FTL | ferritin, light polypeptide | -0.0473051 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0465861 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0451093 |
| JMJD1C | jumonji domain containing 1C | -0.0432898 |
| VIM | vimentin | -0.0427691 |
| MT1E | metallothionein 1E | -0.0414499 |
| RPS8 | ribosomal protein S8 | -0.03935 |
| RPS6 | ribosomal protein S6 | -0.0378706 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0369548 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0363179 |
| RPS19 | ribosomal protein S19 | -0.0360852 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0326188 |
| FOSL1 | FOS-like antigen 1 | -0.0321824 |
| RPLP1 | ribosomal protein, large, P1 | -0.0320495 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0313785 |
| RPLP0 | ribosomal protein, large, P0 | -0.0307658 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.030648 |
| YBX3 | Y box binding protein 3 | -0.030115 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0300845 |
| ANGPTL4 | angiopoietin-like 4 | -0.0280055 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0279436 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.027904 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0272044 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0269544 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0265141 |
| ANXA2 | annexin A2 | -0.0264078 |
| S100A10 | S100 calcium binding protein A10 | -0.0262348 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0252388 |
| RRBP1 | ribosome binding protein 1 | -0.0250891 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0248722 |
| MT1X | metallothionein 1X | -0.0243545 |
| SMYD3 | SET and MYND domain containing 3 | -0.0234549 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0231783 |
| NDRG1 | N-myc downstream regulated 1 | -0.0230634 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0226466 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.022332 |
| ACTG1 | actin gamma 1 | -0.0222767 |
| RPL11 | ribosomal protein L11 | -0.0222637 |
| ATF4 | activating transcription factor 4 | -0.021698 |
| PHF21A | PHD finger protein 21A | -0.0213977 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0208014 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0207768 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0206128 |
| CALD1 | caldesmon 1 | -0.0205991 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0204704 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0202643 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0201471 |
| SEPTIN7 | septin 7 | -0.0200053 |
| FBXO11 | F-box protein 11 | -0.0195083 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0191753 |
| SYAP1 | synapse associated protein 1 | -0.0191715 |
| RPS20 | ribosomal protein S20 | -0.0190317 |
| HM13 | histocompatibility (minor) 13 | -0.0187497 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0186349 |
| RPL36 | ribosomal protein L36 | -0.018509 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0184823 |
| RPL34 | ribosomal protein L34 | -0.0181571 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0179003 |
| ARF1 | ADP-ribosylation factor 1 | -0.0176133 |
| CAVIN1 | caveolae associated protein 1 | -0.0175673 |
| ANK2 | ankyrin 2, neuronal | -0.0175232 |
| PODXL | podocalyxin-like | -0.0172468 |
| PRDX1 | peroxiredoxin 1 | -0.0171454 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0170484 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0167388 |
| SESN2 | sestrin 2 | -0.0165806 |
| RPS4X | ribosomal protein S4, X-linked | -0.0165337 |
| RPL32 | ribosomal protein L32 | -0.0161779 |
| SLC38A1 | solute carrier family 38, member 1 | -0.016158 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0161056 |
| RPL12 | ribosomal protein L12 | -0.0160832 |
| KRT18 | keratin 18, type I | -0.0160294 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0160241 |
| H1-0 | H1.0 linker histone | -0.0159011 |
| EZR | ezrin | -0.0158112 |
| RPS28 | ribosomal protein S28 | -0.0156135 |
| EMP1 | epithelial membrane protein 1 | -0.015519 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0150525 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0150249 |
| PYGB | phosphorylase, glycogen; brain | -0.0148019 |
| FNDC3B | fibronectin type III domain containing 3B | -0.014789 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0146847 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0146511 |
| RPL35 | ribosomal protein L35 | -0.0146334 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0144549 |
| RAD51B | RAD51 paralog B | -0.0143973 |
| RPS27 | ribosomal protein S27 | -0.0143818 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0143347 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0139949 |
| RLF | rearranged L-myc fusion | -0.0138529 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0137943 |
