| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.239871 |
| EGFR | epidermal growth factor receptor | 0.235705 |
| LAMC2 | laminin, gamma 2 | 0.137511 |
| UBC | ubiquitin C | 0.12812 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.123214 |
| FAM13A | family with sequence similarity 13, member A | 0.104652 |
| SPAG9 | sperm associated antigen 9 | 0.0940317 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0936415 |
| NGLY1 | N-glycanase 1 | 0.0890139 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0877957 |
| ATP13A3 | ATPase type 13A3 | 0.0779036 |
| LAMB3 | laminin, beta 3 | 0.0754562 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0741576 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0740393 |
| HDLBP | high density lipoprotein binding protein | 0.0718611 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0669768 |
| PGK1 | phosphoglycerate kinase 1 | 0.0668423 |
| WDR45B | WD repeat domain 45B | 0.0667268 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.065922 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0647832 |
| USP34 | ubiquitin specific peptidase 34 | 0.0645953 |
| ANXA5 | annexin A5 | 0.0628196 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0627292 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0621448 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0616376 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0615069 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0613294 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0606658 |
| TMEM165 | transmembrane protein 165 | 0.0606048 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0604458 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0600149 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0598798 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0586477 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0580478 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0576317 |
| SMAD3 | SMAD family member 3 | 0.0575779 |
| RUNX1 | runt-related transcription factor 1 | 0.0568341 |
| PUM2 | pumilio RNA-binding family member 2 | 0.055628 |
| SLTM | SAFB-like, transcription modulator | 0.0551746 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0545771 |
| ENO1 | enolase 1, (alpha) | 0.0544796 |
| CES1 | carboxylesterase 1 | 0.0543815 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.054207 |
| OGA | O-GlcNAcase | 0.053455 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0529812 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0526957 |
| PCBP2 | poly(rC) binding protein 2 | 0.0524793 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0524375 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0518165 |
| ECT2 | epithelial cell transforming 2 | 0.0517104 |
| RASA2 | RAS p21 protein activator 2 | 0.0507945 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0507616 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0504813 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0497267 |
| MCL1 | myeloid cell leukemia 1 | 0.0490758 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0489999 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0480186 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0478054 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0466764 |
| PKM | pyruvate kinase, muscle | 0.0465096 |
| NDRG1 | N-myc downstream regulated 1 | 0.0464123 |
| SEC61G | Sec61 gamma subunit | 0.045897 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0458319 |
| AHNAK | AHNAK nucleoprotein | 0.0451901 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0449011 |
| CANX | calnexin | 0.0438871 |
| NUP58 | nucleoporin 58 | 0.0425528 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0421755 |
| MKI67 | marker of proliferation Ki-67 | 0.0408573 |
| NPTN | neuroplastin | 0.0405748 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0405663 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0400484 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0399124 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0398427 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0394886 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0391614 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0390924 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0383997 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.03817 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0372636 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0372516 |
| ASPH | aspartate beta-hydroxylase | 0.0369865 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0368566 |
| PAPOLA | poly(A) polymerase alpha | 0.0366699 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0366494 |
| ZNF638 | zinc finger protein 638 | 0.0366148 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0364028 |
| CSNK1E | casein kinase 1, epsilon | 0.0360992 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0360523 |
| FNIP1 | folliculin interacting protein 1 | 0.0354823 |
| UVRAG | UV radiation resistance associated | 0.0354448 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0353736 |
| SLMAP | sarcolemma associated protein | 0.0353579 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0351418 |
| TFG | TRK-fused gene | 0.0349918 |
| EP300 | E1A binding protein p300 | 0.0349268 |
| TPD52 | tumor protein D52 | 0.0344302 |
| RLF | rearranged L-myc fusion | 0.0343402 |
| HELZ | helicase with zinc finger | 0.0342145 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0339849 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.116999 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0840286 |
| MT2A | metallothionein 2A | -0.0804926 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0723267 |
| EGR1 | early growth response 1 | -0.07026 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0591859 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0583132 |
| AREG | amphiregulin | -0.0543629 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0522421 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0517115 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.047681 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0471706 |
| RNF213 | ring finger protein 213 | -0.0463346 |
| RPLP1 | ribosomal protein, large, P1 | -0.0455986 |
| SLC38A1 | solute carrier family 38, member 1 | -0.04433 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0426345 |
| GRAMD1B | GRAM domain containing 1B | -0.0420934 |
| RAD51B | RAD51 paralog B | -0.0414922 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0399418 |
| RPL35A | ribosomal protein L35a | -0.0397712 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0394912 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0379376 |
| S100A10 | S100 calcium binding protein A10 | -0.0371925 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0369946 |
| FTL | ferritin, light polypeptide | -0.0369438 |
| CCND1 | cyclin D1 | -0.0353739 |
| CST3 | cystatin C | -0.0338005 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0332463 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0330379 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0327623 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0326888 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.032274 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0321704 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0311981 |
| B2M | beta-2-microglobulin | -0.0311948 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0308353 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0303172 |
| TOP1 | topoisomerase (DNA) I | -0.0299338 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.029933 |
| EFNA5 | ephrin-A5 | -0.0294364 |
| TJP1 | tight junction protein 1 | -0.0293411 |
| FOXP1 | forkhead box P1 | -0.0285876 |
| VCL | vinculin | -0.028531 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0282317 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0280588 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0279877 |
| RPS12 | ribosomal protein S12 | -0.0275044 |
| KRT7 | keratin 7, type II | -0.0275021 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0272887 |
| S100A11 | S100 calcium binding protein A11 | -0.026767 |
| RPS6 | ribosomal protein S6 | -0.0266096 |
| SMYD3 | SET and MYND domain containing 3 | -0.0257034 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0253232 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0252135 |
| RPS29 | ribosomal protein S29 | -0.0249565 |
| S100A9 | S100 calcium binding protein A9 | -0.0246863 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0241807 |
| SYAP1 | synapse associated protein 1 | -0.0235253 |
| GPHN | gephyrin | -0.0234189 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0232268 |
| RPLP2 | ribosomal protein, large, P2 | -0.0231121 |
| CUX1 | cut-like homeobox 1 | -0.0230477 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0229679 |
| RPS19 | ribosomal protein S19 | -0.0226596 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.022547 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0215344 |
| CCNL1 | cyclin L1 | -0.021348 |
| RPL34 | ribosomal protein L34 | -0.0213281 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0211573 |
| KRT18 | keratin 18, type I | -0.0206296 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0204518 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.020451 |
| NTN4 | netrin 4 | -0.0202338 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0199714 |
| MYOF | myoferlin | -0.0199053 |
| ACTG1 | actin gamma 1 | -0.019738 |
| MYO1E | myosin IE | -0.0197089 |
| HLA-B | major histocompatibility complex, class I, B | -0.019359 |
| RPS27 | ribosomal protein S27 | -0.0193393 |
| RPS23 | ribosomal protein S23 | -0.0193392 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0192457 |
| RPL19 | ribosomal protein L19 | -0.0190703 |
| SP100 | SP100 nuclear antigen | -0.0190201 |
| RPL11 | ribosomal protein L11 | -0.0188706 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0187698 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.018689 |
| FOSL1 | FOS-like antigen 1 | -0.0186808 |
| MX1 | MX dynamin-like GTPase 1 | -0.0186188 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0183983 |
| GOLGB1 | golgin B1 | -0.0182245 |
| SERF2 | small EDRK-rich factor 2 | -0.0178641 |
| MGAT4C | MGAT4 family, member C | -0.0176326 |
| IFI44L | interferon-induced protein 44-like | -0.0176301 |
| CD163L1 | CD163 molecule-like 1 | -0.017447 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0173928 |
| RPL9 | ribosomal protein L9 | -0.0173559 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0173257 |
| RIN2 | Ras and Rab interactor 2 | -0.0173004 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0172049 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.017151 |
