Digitoxin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.14214
PCBP2 poly(rC) binding protein 2 0.133806
FNDC3B fibronectin type III domain containing 3B 0.118254
NAMPT nicotinamide phosphoribosyltransferase 0.114972
RBM39 RNA binding motif protein 39 0.103151
GRB10 growth factor receptor-bound protein 10 0.0992981
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0923894
USP34 ubiquitin specific peptidase 34 0.0903308
UBC ubiquitin C 0.0874187
CD44 CD44 molecule (Indian blood group) 0.0864246
STC1 stanniocalcin 1 0.0805006
AKAP13 A kinase (PRKA) anchor protein 13 0.0762297
SMAD3 SMAD family member 3 0.0746226
GOLGA4 golgin A4 0.074523
RICTOR RPTOR independent companion of MTOR, complex 2 0.0731582
SOD2 superoxide dismutase 2, mitochondrial 0.0684193
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0677594
ATP13A3 ATPase type 13A3 0.0675787
FAM13A family with sequence similarity 13, member A 0.0668584
UBA6 ubiquitin-like modifier activating enzyme 6 0.0651642
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0647603
KYNU kynureninase 0.0642466
TRIO trio Rho guanine nucleotide exchange factor 0.0641102
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0618337
PID1 phosphotyrosine interaction domain containing 1 0.0581572
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0577336
PDE4D phosphodiesterase 4D, cAMP-specific 0.0567087
KDM2A lysine (K)-specific demethylase 2A 0.056164
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0559932
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0542011
NAV2 neuron navigator 2 0.0536539
EFNA5 ephrin-A5 0.0533006
SPAG9 sperm associated antigen 9 0.0527385
FN1 fibronectin 1 0.0521933
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0521473
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0518398
TM4SF1 transmembrane 4 L six family member 1 0.0516514
ZEB2 zinc finger E-box binding homeobox 2 0.0516075
DSCAM Down syndrome cell adhesion molecule 0.051222
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0511505
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0509266
KDM3A lysine (K)-specific demethylase 3A 0.0501218
EEF2 eukaryotic translation elongation factor 2 0.0486949
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0486748
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0479201
SDK1 sidekick cell adhesion molecule 1 0.047856
PDIA3 protein disulfide isomerase family A, member 3 0.0473714
NGLY1 N-glycanase 1 0.0473422
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0471872
ENO1 enolase 1, (alpha) 0.0455494
WAC WW domain containing adaptor with coiled-coil 0.0449609
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0446942
APP amyloid beta (A4) precursor protein 0.0443502
STRN3 striatin, calmodulin binding protein 3 0.0434803
PARD3 par-3 family cell polarity regulator 0.0434349
SIK3 SIK family kinase 3 0.0432483
PSD3 pleckstrin and Sec7 domain containing 3 0.042827
OGA O-GlcNAcase 0.0427601
DOCK5 dedicator of cytokinesis 5 0.0422276
ESYT2 extended synaptotagmin-like protein 2 0.0420931
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0417861
OXSR1 oxidative stress responsive 1 0.0416421
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0411946
RNF145 ring finger protein 145 0.0389693
PIAS2 protein inhibitor of activated STAT, 2 0.0386326
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0385488
BASP1 brain abundant, membrane attached signal protein 1 0.0385254
HMGA2 high mobility group AT-hook 2 0.0381132
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0380731
AHR aryl hydrocarbon receptor 0.0380555
RUNX2 runt-related transcription factor 2 0.0378476
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.037631
ELL2 elongation factor, RNA polymerase II, 2 0.0376211
MYO1B myosin IB 0.0373387
VMP1 vacuole membrane protein 1 0.0370408
FLNB filamin B, beta 0.0369655
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0369538
MTSS1 metastasis suppressor 1 0.0361952
NBAS neuroblastoma amplified sequence 0.0357442
RAB8B RAB8B, member RAS oncogene family 0.0356648
FAM107B family with sequence similarity 107, member B 0.0355553
HELZ helicase with zinc finger 0.0354362
PRRC2C proline-rich coiled-coil 2C 0.0354174
NRP1 neuropilin 1 0.0352726
DPYSL3 dihydropyrimidinase-like 3 0.0352533
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0346473
JARID2 jumonji, AT rich interactive domain 2 0.03442
LMAN1 lectin, mannose-binding, 1 0.0341158
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.034098
CD109 CD109 molecule 0.0340553
KMT2C lysine (K)-specific methyltransferase 2C 0.0339779
PKM pyruvate kinase, muscle 0.0338214
HDLBP high density lipoprotein binding protein 0.0336004
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0334329
TNIP1 TNFAIP3 interacting protein 1 0.0333511
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0333001
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0332636
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329217
KIF5B kinesin family member 5B 0.0326111
SEC23A Sec23 homolog A (S. cerevisiae) 0.0325598

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110027
TMSB10 thymosin beta 10 -0.105788
RPLP1 ribosomal protein, large, P1 -0.0928538
FTL ferritin, light polypeptide -0.0880016
PTMA prothymosin, alpha -0.0756657
RPS19 ribosomal protein S19 -0.0715953
MT2A metallothionein 2A -0.0665701
RPL35A ribosomal protein L35a -0.0593148
RPL34 ribosomal protein L34 -0.0508049
RPS29 ribosomal protein S29 -0.0497742
VIM vimentin -0.0487411
RPS6 ribosomal protein S6 -0.048266
RPS8 ribosomal protein S8 -0.0479146
RPS21 ribosomal protein S21 -0.0455623
TPT1 tumor protein, translationally-controlled 1 -0.045222
RPLP2 ribosomal protein, large, P2 -0.0442305
RPL36 ribosomal protein L36 -0.0407553
RPLP0 ribosomal protein, large, P0 -0.0398026
RPL9 ribosomal protein L9 -0.0383021
RPL32 ribosomal protein L32 -0.0377027
RPL23 ribosomal protein L23 -0.0374104
RPL11 ribosomal protein L11 -0.0366741
RPS13 ribosomal protein S13 -0.0356913
IER3 immediate early response 3 -0.0340911
RPL37A ribosomal protein L37a -0.0335777
RPL31 ribosomal protein L31 -0.0334216
GPC6 glypican 6 -0.0328579
RPS3 ribosomal protein S3 -0.0323133
RPL12 ribosomal protein L12 -0.0311784
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0307768
RPS12 ribosomal protein S12 -0.0306427
RPS23 ribosomal protein S23 -0.0300476
RPL37 ribosomal protein L37 -0.0296078
EGR1 early growth response 1 -0.0290417
RPL19 ribosomal protein L19 -0.0289614
RPL5 ribosomal protein L5 -0.0287474
RPS16 ribosomal protein S16 -0.0287149
EIF1 eukaryotic translation initiation factor 1 -0.0283332
C15ORF48 chromosome 15 open reading frame 48 -0.0281566
RPS24 ribosomal protein S24 -0.0281252
LOC102724023 ES1 protein homolog, mitochondrial -0.028113
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0277968
S100A9 S100 calcium binding protein A9 -0.027077
DDIT3 DNA-damage-inducible transcript 3 -0.026048
RPS27 ribosomal protein S27 -0.0258835
SLC38A1 solute carrier family 38, member 1 -0.0253964
RPS17 ribosomal protein S17 -0.0245575
RPL28 ribosomal protein L28 -0.0239593
RPL18 ribosomal protein L18 -0.0238223
S100A6 S100 calcium binding protein A6 -0.0233839
RPL38 ribosomal protein L38 -0.0229607
RPS25 ribosomal protein S25 -0.0225678
RAD51B RAD51 paralog B -0.0222817
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0222376
RPS14 ribosomal protein S14 -0.0220939
RPL26 ribosomal protein L26 -0.0214365
RPS27A ribosomal protein S27a -0.0214207
RPS5 ribosomal protein S5 -0.0213411
S100A10 S100 calcium binding protein A10 -0.0209595
ACTG1 actin gamma 1 -0.0203788
RPL13A ribosomal protein L13a -0.0203514
RPL7A ribosomal protein L7a -0.0200049
RAB7A RAB7A, member RAS oncogene family -0.0199764
RPS11 ribosomal protein S11 -0.0196065
HMGA1 high mobility group AT-hook 1 -0.019525
RPS10 ribosomal protein S10 -0.0189081
HLA-B major histocompatibility complex, class I, B -0.0187633
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0186431
RPL27A ribosomal protein L27a -0.0186174
RPL36A ribosomal protein L36a -0.0183903
RACK1 receptor for activated C kinase 1 -0.0181131
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0179925
FTH1 ferritin, heavy polypeptide 1 -0.0178988
RPS20 ribosomal protein S20 -0.0176819
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0176619
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0172638
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0171997
RPL30 ribosomal protein L30 -0.0171818
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0171378
NTN4 netrin 4 -0.017038
RPL36AL ribosomal protein L36a-like -0.0169496
RPL8 ribosomal protein L8 -0.0169183
RPL27 ribosomal protein L27 -0.0166085
RPL7 ribosomal protein L7 -0.0164797
RPL35 ribosomal protein L35 -0.0163971
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0163894
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0162353
SAMD9 sterile alpha motif domain containing 9 -0.0161201
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.016057
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0158914
INSIG1 insulin induced gene 1 -0.0157522
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0156073
KLF6 Kruppel-like factor 6 -0.0155492
KCTD16 potassium channel tetramerization domain containing 16 -0.0153917
LOX lysyl oxidase -0.0152708
IGFBP3 insulin-like growth factor binding protein 3 -0.0152562
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0151918
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0147965
SRGN serglycin -0.0146563
NDUFA4 NDUFA4, mitochondrial complex associated -0.0146483