Digitoxin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.102638
TM4SF1 transmembrane 4 L six family member 1 0.0970658
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0961618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0837091
UBC ubiquitin C 0.0812002
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0748736
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0690214
PTK2 protein tyrosine kinase 2 0.06784
EEF2 eukaryotic translation elongation factor 2 0.0666463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0655936
HSPA8 heat shock 70kDa protein 8 0.0623443
ZFAND3 zinc finger, AN1-type domain 3 0.0619005
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0574705
RBM39 RNA binding motif protein 39 0.0572613
APP amyloid beta (A4) precursor protein 0.0560104
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0545102
WDR43 WD repeat domain 43 0.0542092
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0538776
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0525168
SAMD4A sterile alpha motif domain containing 4A 0.0518277
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0509179
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0499994
SPAG9 sperm associated antigen 9 0.0478213
USP34 ubiquitin specific peptidase 34 0.047478
DENND4A DENN/MADD domain containing 4A 0.0462012
TPM3 tropomyosin 3 0.0460356
BRD2 bromodomain containing 2 0.0448372
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0442427
PUM1 pumilio RNA-binding family member 1 0.0442172
RHEB Ras homolog enriched in brain 0.0440951
MACF1 microtubule-actin crosslinking factor 1 0.0434751
MCL1 myeloid cell leukemia 1 0.0431722
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0426994
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0418966
CXCL8 chemokine (C-X-C motif) ligand 8 0.0411263
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0408527
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0394092
RAD21 RAD21 homolog (S. pombe) 0.0388518
KDM3A lysine (K)-specific demethylase 3A 0.0381297
ASPH aspartate beta-hydroxylase 0.0378862
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0378254
RPL4 ribosomal protein L4 0.0372524
EIF4A1 eukaryotic translation initiation factor 4A1 0.0371625
ANKRD11 ankyrin repeat domain 11 0.0367845
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0366407
CFLAR CASP8 and FADD-like apoptosis regulator 0.0362985
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0358962
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0354171
TRIO trio Rho guanine nucleotide exchange factor 0.0348782
WIPF2 WAS/WASL interacting protein family, member 2 0.0348066
EIF4A3 eukaryotic translation initiation factor 4A3 0.0342859
AHNAK AHNAK nucleoprotein 0.0339853
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0338245
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0337876
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0337441
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0335732
CALR calreticulin 0.0334091
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0326169
FAM107B family with sequence similarity 107, member B 0.0325747
ENO1 enolase 1, (alpha) 0.0321151
RTN4 reticulon 4 0.031729
POTEF POTE ankyrin domain family, member F 0.0316135
SFPQ splicing factor proline/glutamine-rich 0.0316033
EIF4A2 eukaryotic translation initiation factor 4A2 0.0314389
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0310262
JUN jun proto-oncogene 0.0309786
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0307947
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0307946
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0305453
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0303317
BIRC3 baculoviral IAP repeat containing 3 0.0301839
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0301818
MKI67 marker of proliferation Ki-67 0.0298231
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0297528
PARD3 par-3 family cell polarity regulator 0.0296512
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0295499
INO80 INO80 complex subunit 0.0291575
MARCHF6 membrane associated ring-CH-type finger 6 0.0288965
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0286356
CMIP c-Maf inducing protein 0.0283755
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0283683
RASAL2 RAS protein activator like 2 0.0281807
CAMTA1 calmodulin binding transcription activator 1 0.0281166
WAC WW domain containing adaptor with coiled-coil 0.0280449
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0277164
PAPOLA poly(A) polymerase alpha 0.0275108
NOP58 NOP58 ribonucleoprotein 0.0270278
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0269709
PUM2 pumilio RNA-binding family member 2 0.0266389
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265932
VMP1 vacuole membrane protein 1 0.0264938
UBAP2L ubiquitin associated protein 2-like 0.0263907
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0261862
PCBP2 poly(rC) binding protein 2 0.0258069
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257902
GLG1 golgi glycoprotein 1 0.0257085
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0254624
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0250648
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0248272
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0246413

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.266068
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14823
FTL ferritin, light polypeptide -0.147489
TMSB10 thymosin beta 10 -0.102312
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.051591
FTH1 ferritin, heavy polypeptide 1 -0.0439888
RPLP1 ribosomal protein, large, P1 -0.0434508
RPS19 ribosomal protein S19 -0.0430631
PM20D1 peptidase M20 domain containing 1 -0.0428049
RPL19 ribosomal protein L19 -0.0425127
RPLP0 ribosomal protein, large, P0 -0.0352321
RPS8 ribosomal protein S8 -0.0352048
RPL36 ribosomal protein L36 -0.0332244
PTMA prothymosin, alpha -0.0277704
RPS29 ribosomal protein S29 -0.0267013
RPL35A ribosomal protein L35a -0.0260048
RPS21 ribosomal protein S21 -0.0260019
RPS6 ribosomal protein S6 -0.0242844
RPS23 ribosomal protein S23 -0.0240348
RPL31 ribosomal protein L31 -0.0234964
RPL37A ribosomal protein L37a -0.0230152
RPLP2 ribosomal protein, large, P2 -0.0225783
SERF2 small EDRK-rich factor 2 -0.0225623
ATP5F1E ATP synthase F1 subunit epsilon -0.0222411
HMGA1 high mobility group AT-hook 1 -0.0221174
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0220745
PFN1 profilin 1 -0.0215003
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0212868
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0212326
C15ORF48 chromosome 15 open reading frame 48 -0.0209785
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.019888
AKAP12 A kinase (PRKA) anchor protein 12 -0.0196538
RPL9 ribosomal protein L9 -0.0192296
RPS17 ribosomal protein S17 -0.0192054
S100A10 S100 calcium binding protein A10 -0.018291
PRR16 proline rich 16 -0.0179421
TPT1 tumor protein, translationally-controlled 1 -0.0174503
S100A9 S100 calcium binding protein A9 -0.0171762
RPL36AL ribosomal protein L36a-like -0.0163933
RPS15 ribosomal protein S15 -0.0163589
KLF6 Kruppel-like factor 6 -0.0163074
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0161528
RPL8 ribosomal protein L8 -0.0161039
RPL23 ribosomal protein L23 -0.0156931
RPL37 ribosomal protein L37 -0.0155927
PDE4D phosphodiesterase 4D, cAMP-specific -0.0154936
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0152825
RPS14 ribosomal protein S14 -0.0150057
RPS16 ribosomal protein S16 -0.0148965
RPL26 ribosomal protein L26 -0.0144281
S100A6 S100 calcium binding protein A6 -0.0143922
NNMT nicotinamide N-methyltransferase -0.0141835
EGR1 early growth response 1 -0.0139643
RPS20 ribosomal protein S20 -0.0139507
LGALS1 lectin, galactoside-binding, soluble, 1 -0.013909
HMGB1 high mobility group box 1 -0.013737
RPL30 ribosomal protein L30 -0.0137049
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0135466
RPL28 ribosomal protein L28 -0.0133184
VDAC1 voltage-dependent anion channel 1 -0.0132962
RPL27 ribosomal protein L27 -0.0130357
MT1X metallothionein 1X -0.0124238
ASTN2 astrotactin 2 -0.0122565
RPL38 ribosomal protein L38 -0.0121985
RPL11 ribosomal protein L11 -0.0121189
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0120566
CNRIP1 cannabinoid receptor interacting protein 1 -0.0117933
VIM vimentin -0.0117864
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0116691
RPS5 ribosomal protein S5 -0.0115444
RPS27 ribosomal protein S27 -0.0114063
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0113921
RPL7 ribosomal protein L7 -0.0113722
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0113293
RPL32 ribosomal protein L32 -0.0113041
ISG15 ISG15 ubiquitin-like modifier -0.0110425
RPS13 ribosomal protein S13 -0.010983
RAD51B RAD51 paralog B -0.0108371
LDHB lactate dehydrogenase B -0.0108228
NEBL nebulette -0.0107494
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0106476
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0105498
RPS25 ribosomal protein S25 -0.0101743
FGG fibrinogen gamma chain -0.0101594
S100A11 S100 calcium binding protein A11 -0.010135
RACK1 receptor for activated C kinase 1 -0.0100445
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.00975619
RPL12 ribosomal protein L12 -0.00974597
RPL36A ribosomal protein L36a -0.009723
SOX4 SRY (sex determining region Y)-box 4 -0.00968222
RPL34 ribosomal protein L34 -0.00967454
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.00958402
RPL18 ribosomal protein L18 -0.00948189
ROMO1 reactive oxygen species modulator 1 -0.00947542
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00939914
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.00935459
NHSL1 NHS-like 1 -0.00931531
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.00930115
LOC102724023 ES1 protein homolog, mitochondrial -0.0092983
GPX1 glutathione peroxidase 1 -0.00923457