| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.230576 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.130571 |
| TMSB10 | thymosin beta 10 | 0.126012 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.114791 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.114192 |
| JUN | jun proto-oncogene | 0.103785 |
| UBC | ubiquitin C | 0.102944 |
| SQSTM1 | sequestosome 1 | 0.0834232 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0825033 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0744613 |
| RPS27A | ribosomal protein S27a | 0.0741875 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0704747 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.070045 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0699567 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0674896 |
| CCNL1 | cyclin L1 | 0.0663655 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0662696 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0662363 |
| TOP1 | topoisomerase (DNA) I | 0.0659574 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0649821 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0647366 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.064187 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0640735 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0636599 |
| RLF | rearranged L-myc fusion | 0.0623774 |
| QKI | QKI, KH domain containing, RNA binding | 0.0614002 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.059812 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0587251 |
| DIAPH1 | diaphanous-related formin 1 | 0.0586851 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0580333 |
| RBM39 | RNA binding motif protein 39 | 0.0576941 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0562793 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0552168 |
| MT2A | metallothionein 2A | 0.0547196 |
| ZNF292 | zinc finger protein 292 | 0.0543588 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0541163 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0538678 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0537637 |
| FLNB | filamin B, beta | 0.0534603 |
| VMP1 | vacuole membrane protein 1 | 0.0523346 |
| NUP58 | nucleoporin 58 | 0.0518109 |
| SETD5 | SET domain containing 5 | 0.0503229 |
| LDHA | lactate dehydrogenase A | 0.0497732 |
| WAC | WW domain containing adaptor with coiled-coil | 0.049656 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0488207 |
| RPL23 | ribosomal protein L23 | 0.0486899 |
| RPS3 | ribosomal protein S3 | 0.0485724 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0480681 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0473281 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0467976 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.04645 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0459257 |
| CALR | calreticulin | 0.0453725 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.045081 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0450258 |
| SET | SET nuclear proto-oncogene | 0.0448201 |
| FN1 | fibronectin 1 | 0.044297 |
| PKM | pyruvate kinase, muscle | 0.0441924 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0436993 |
| S100A6 | S100 calcium binding protein A6 | 0.0429949 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0424704 |
| GOLGA4 | golgin A4 | 0.042444 |
| CRY1 | cryptochrome circadian clock 1 | 0.0422462 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0421205 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0420782 |
| TFRC | transferrin receptor | 0.0419063 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0417682 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0417462 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0413449 |
| SPPL3 | signal peptide peptidase like 3 | 0.0412614 |
| HSPA1A | heat shock 70kDa protein 1A | 0.040474 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0403547 |
| AHNAK | AHNAK nucleoprotein | 0.0400861 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0400373 |
| FUS | FUS RNA binding protein | 0.0400279 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0397018 |
| CALU | calumenin | 0.0387646 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0387048 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.038397 |
| VIM | vimentin | 0.0381316 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0378026 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0374542 |
| RPL37A | ribosomal protein L37a | 0.0364464 |
| MED13 | mediator complex subunit 13 | 0.0364207 |
| RHEB | Ras homolog enriched in brain | 0.0362792 |
| BRD2 | bromodomain containing 2 | 0.0361371 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0358561 |
| RPS19 | ribosomal protein S19 | 0.0357866 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0357479 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0356115 |
| KLHL24 | kelch-like family member 24 | 0.0353869 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.035254 |
| RTN4 | reticulon 4 | 0.0350093 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0345538 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0339178 |
| ADM | adrenomedullin | 0.033892 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0338597 |
| YTHDC1 | YTH domain containing 1 | 0.0336867 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0334612 |
| ACTG1 | actin gamma 1 | 0.0334533 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.23482 |
| MYO1E | myosin IE | -0.163912 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0910674 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0885813 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0833402 |
| NDRG1 | N-myc downstream regulated 1 | -0.0744238 |
| LAMB3 | laminin, beta 3 | -0.0720097 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0706077 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0698 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0681076 |
| RAD51B | RAD51 paralog B | -0.0672808 |
| OSMR | oncostatin M receptor | -0.067092 |
| IGF2 | insulin-like growth factor 2 | -0.0630019 |
| VCL | vinculin | -0.0616814 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0610352 |
| KYNU | kynureninase | -0.060954 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0608871 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0600941 |
| LMO7 | LIM domain 7 | -0.0593426 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0549229 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0542681 |
| SMYD3 | SET and MYND domain containing 3 | -0.0535515 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0522557 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0519346 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0499476 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0498767 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0484416 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0483439 |
| STC1 | stanniocalcin 1 | -0.0481695 |
| ATOSA | atos homolog A | -0.046596 |
| EFNA5 | ephrin-A5 | -0.0465713 |
| FOXP1 | forkhead box P1 | -0.0465516 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0465311 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0456079 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0452604 |
| FMN1 | formin 1 | -0.0450958 |
| PRKCA | protein kinase C, alpha | -0.0440328 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0428789 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.04285 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0427506 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0425811 |
| CDCP1 | CUB domain containing protein 1 | -0.0422347 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0422207 |
| ANXA1 | annexin A1 | -0.0418535 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0416605 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0414944 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0411983 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0409451 |
| DST | dystonin | -0.0408611 |
| GRAMD2B | GRAM domain containing 2B | -0.0406874 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0402712 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0398615 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0396528 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0394988 |
| RNF213 | ring finger protein 213 | -0.0391863 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0386893 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0382805 |
| EXOC4 | exocyst complex component 4 | -0.0382332 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0381527 |
| TMEM87A | transmembrane protein 87A | -0.0381508 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0378719 |
| LUZP1 | leucine zipper protein 1 | -0.037655 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0375234 |
| DSPP | dentin sialophosphoprotein | -0.0375101 |
| BPTF | bromodomain PHD finger transcription factor | -0.0370919 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0370363 |
| PRSS23 | protease, serine, 23 | -0.0370047 |
| FAM107B | family with sequence similarity 107, member B | -0.0365333 |
| SASH1 | SAM and SH3 domain containing 1 | -0.03637 |
| RBM47 | RNA binding motif protein 47 | -0.0361297 |
| GLCCI1 | glucocorticoid induced 1 | -0.0360204 |
| RAI14 | retinoic acid induced 14 | -0.0359437 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.035881 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0352891 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0352753 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.034979 |
| PRELID2 | PRELI domain containing 2 | -0.0343004 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0342896 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0342749 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.034234 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0341384 |
| METTL15 | methyltransferase like 15 | -0.0341318 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0339272 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0336321 |
| ZNF217 | zinc finger protein 217 | -0.0335002 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0334594 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0334241 |
| HMGA2 | high mobility group AT-hook 2 | -0.0333197 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.033239 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0331376 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0330038 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0329704 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0327358 |
| SP100 | SP100 nuclear antigen | -0.0325573 |
| RIGI | RNA sensor RIG-I | -0.0324492 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0324384 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0323811 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0322968 |
| EHBP1 | EH domain binding protein 1 | -0.0322304 |
| LAMC2 | laminin, gamma 2 | -0.0321576 |
