Digitoxin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.23929
TOP2A topoisomerase (DNA) II alpha 170kDa 0.139521
TXNRD1 thioredoxin reductase 1 0.107478
GRAMD1B GRAM domain containing 1B 0.0955646
EEF2 eukaryotic translation elongation factor 2 0.09093
TPM3 tropomyosin 3 0.0886453
RRM2 ribonucleotide reductase M2 0.0853765
MKI67 marker of proliferation Ki-67 0.0771506
ZNF638 zinc finger protein 638 0.0748406
UBC ubiquitin C 0.0744317
ENO1 enolase 1, (alpha) 0.072365
NCAPD2 non-SMC condensin I complex, subunit D2 0.0668188
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0652066
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0625681
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0619149
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0563521
KTN1 kinectin 1 (kinesin receptor) 0.0550411
PCBP2 poly(rC) binding protein 2 0.0531675
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0507105
USP34 ubiquitin specific peptidase 34 0.0501353
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0498512
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0493274
SMC4 structural maintenance of chromosomes 4 0.0486812
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0477749
TPI1 triosephosphate isomerase 1 0.0457523
OGA O-GlcNAcase 0.0437299
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0427253
ANKRD36 ankyrin repeat domain 36 0.0423631
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0423005
SRRM1 serine/arginine repetitive matrix 1 0.0419348
SRPK1 SRSF protein kinase 1 0.0417366
PHIP pleckstrin homology domain interacting protein 0.0413386
TPX2 TPX2, microtubule-associated 0.0412572
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0412157
EIF4A1 eukaryotic translation initiation factor 4A1 0.0412077
BBX bobby sox homolog (Drosophila) 0.0410001
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0407126
CSDE1 cold shock domain containing E1, RNA-binding 0.0405273
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0402481
CEP192 centrosomal protein 192kDa 0.0402151
NF1 neurofibromin 1 0.0400578
MELK maternal embryonic leucine zipper kinase 0.0396805
CENPF centromere protein F, 350/400kDa 0.0393417
TAS2R14 taste receptor, type 2, member 14 0.0392102
GIGYF2 GRB10 interacting GYF protein 2 0.0384079
KDM2A lysine (K)-specific demethylase 2A 0.0383437
XPO1 exportin 1 0.0383008
HP1BP3 heterochromatin protein 1, binding protein 3 0.0382044
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0379946
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.037979
KIF5B kinesin family member 5B 0.0377991
CKAP5 cytoskeleton associated protein 5 0.0376841
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0374728
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0371592
CHD4 chromodomain helicase DNA binding protein 4 0.0371471
BIRC6 baculoviral IAP repeat containing 6 0.0370297
IGF1R insulin-like growth factor 1 receptor 0.0368308
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0367616
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.03609
MCL1 myeloid cell leukemia 1 0.0358711
AURKA aurora kinase A 0.0358326
DCAF7 DDB1 and CUL4 associated factor 7 0.0357693
WSB1 WD repeat and SOCS box containing 1 0.0357381
HSPA8 heat shock 70kDa protein 8 0.0355132
ACTN1 actinin, alpha 1 0.0352287
TMPO thymopoietin 0.0352247
NCAPG2 non-SMC condensin II complex, subunit G2 0.0351392
GPSM2 G-protein signaling modulator 2 0.033901
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0337627
CENPE centromere protein E, 312kDa 0.0337352
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0337283
KIF2C kinesin family member 2C 0.0335059
MSN moesin 0.0333568
TPR translocated promoter region, nuclear basket protein 0.0332866
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.033205
HDGF hepatoma-derived growth factor 0.0331462
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0330291
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0328806
CANX calnexin 0.0328558
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0328081
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0327595
OSMR oncostatin M receptor 0.0327451
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0326647
PRRC2C proline-rich coiled-coil 2C 0.0326196
BRWD1 bromodomain and WD repeat domain containing 1 0.032544
GATAD2B GATA zinc finger domain containing 2B 0.0324939
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0323448
PKM pyruvate kinase, muscle 0.0322396
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0321968
ATL2 atlastin GTPase 2 0.0320505
FNIP1 folliculin interacting protein 1 0.0318379
PDIA4 protein disulfide isomerase family A, member 4 0.031764
ARL5B ADP-ribosylation factor-like 5B 0.0317078
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0314157
CLTC clathrin, heavy chain (Hc) 0.0314142
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0313593
KCMF1 potassium channel modulatory factor 1 0.031286
GON4L gon-4-like (C. elegans) 0.0312845
BRD2 bromodomain containing 2 0.0312167
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0311571

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146057
AKAP12 A kinase (PRKA) anchor protein 12 -0.141495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.099768
TMSB10 thymosin beta 10 -0.0639853
RPLP1 ribosomal protein, large, P1 -0.057122
RPL35A ribosomal protein L35a -0.0554664
PTMA prothymosin, alpha -0.0551931
RPS19 ribosomal protein S19 -0.0544601
TFPI2 tissue factor pathway inhibitor 2 -0.0494508
RAB7A RAB7A, member RAS oncogene family -0.0460946
RPS21 ribosomal protein S21 -0.0447471
RPS3 ribosomal protein S3 -0.0441887
RPL26 ribosomal protein L26 -0.0438606
CAVIN1 caveolae associated protein 1 -0.042883
RPLP0 ribosomal protein, large, P0 -0.0422469
RPS8 ribosomal protein S8 -0.0420909
RPS12 ribosomal protein S12 -0.0389091
RPL37 ribosomal protein L37 -0.0386535
RPS15 ribosomal protein S15 -0.0373443
RPS29 ribosomal protein S29 -0.0371509
GADD45A growth arrest and DNA-damage-inducible, alpha -0.036592
RPL12 ribosomal protein L12 -0.0358207
GPHN gephyrin -0.0357814
RPL37A ribosomal protein L37a -0.0356383
PREPL prolyl endopeptidase-like -0.0352675
RPL34 ribosomal protein L34 -0.0341645
KLF6 Kruppel-like factor 6 -0.0332215
MYL12B myosin, light chain 12B, regulatory -0.0323922
RPL32 ribosomal protein L32 -0.0322343
RPL36 ribosomal protein L36 -0.0321449
RPLP2 ribosomal protein, large, P2 -0.0319045
H1-0 H1.0 linker histone -0.0317595
IER3 immediate early response 3 -0.0312978
MT2A metallothionein 2A -0.0308428
RPL8 ribosomal protein L8 -0.0303503
CREB5 cAMP responsive element binding protein 5 -0.0301764
TRA2A transformer 2 alpha homolog (Drosophila) -0.0297815
LOC102724023 ES1 protein homolog, mitochondrial -0.0296228
RPL23 ribosomal protein L23 -0.029307
FTL ferritin, light polypeptide -0.0281215
TPT1 tumor protein, translationally-controlled 1 -0.0271989
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0255754
RPS25 ribosomal protein S25 -0.0253109
GNAS GNAS complex locus -0.0251578
RPS10 ribosomal protein S10 -0.02472
PCLO piccolo presynaptic cytomatrix protein -0.0246703
RPL5 ribosomal protein L5 -0.0241149
RPL9 ribosomal protein L9 -0.024018
RPL38 ribosomal protein L38 -0.0239433
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0239122
RPL28 ribosomal protein L28 -0.0235375
RPL36A ribosomal protein L36a -0.0233539
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0225627
B2M beta-2-microglobulin -0.0223
RPL11 ribosomal protein L11 -0.0217542
EGR1 early growth response 1 -0.0216194
RPS20 ribosomal protein S20 -0.0215921
RPS17 ribosomal protein S17 -0.0215176
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0214352
S100A9 S100 calcium binding protein A9 -0.0212747
RPL18 ribosomal protein L18 -0.0210803
NDRG1 N-myc downstream regulated 1 -0.0207478
TSC22D2 TSC22 domain family, member 2 -0.019864
RPL31 ribosomal protein L31 -0.0198004
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0194347
RBM39 RNA binding motif protein 39 -0.0192632
JUN jun proto-oncogene -0.0191298
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0190967
RPS16 ribosomal protein S16 -0.0190457
ASTN2 astrotactin 2 -0.0187948
NACA nascent polypeptide-associated complex alpha subunit -0.0186907
SLC38A1 solute carrier family 38, member 1 -0.0185282
RPL27A ribosomal protein L27a -0.0184937
SDC4 syndecan 4 -0.0184084
ATP5F1E ATP synthase F1 subunit epsilon -0.0181416
RPS27 ribosomal protein S27 -0.0181268
UVRAG UV radiation resistance associated -0.0181227
PFN1 profilin 1 -0.0179966
RPL19 ribosomal protein L19 -0.0179901
RPS6 ribosomal protein S6 -0.0179344
S100A10 S100 calcium binding protein A10 -0.0179037
S100A11 S100 calcium binding protein A11 -0.0174446
LIMA1 LIM domain and actin binding 1 -0.0174306
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0172087
WDR43 WD repeat domain 43 -0.0171883
RACK1 receptor for activated C kinase 1 -0.0171677
RAB1A RAB1A, member RAS oncogene family -0.0171104
UBE2H ubiquitin-conjugating enzyme E2H -0.0169218
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0167782
EIF1 eukaryotic translation initiation factor 1 -0.0164786
RPS23 ribosomal protein S23 -0.0164773
ACTG1 actin gamma 1 -0.0163435
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0162416
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0162242
RPL30 ribosomal protein L30 -0.0162001
RPL35 ribosomal protein L35 -0.01618
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0157628
OSBPL9 oxysterol binding protein-like 9 -0.0156151
USP15 ubiquitin specific peptidase 15 -0.0155343
ANXA2 annexin A2 -0.0154673