Digitoxin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.261738
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.216979
SPAG9 sperm associated antigen 9 0.204334
KYNU kynureninase 0.155355
NAMPT nicotinamide phosphoribosyltransferase 0.137213
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.128808
FNDC3A fibronectin type III domain containing 3A 0.122221
UBAP2L ubiquitin associated protein 2-like 0.121497
FN1 fibronectin 1 0.120206
TFPI2 tissue factor pathway inhibitor 2 0.118531
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.106603
PDE4D phosphodiesterase 4D, cAMP-specific 0.100988
USP36 ubiquitin specific peptidase 36 0.0964279
MCL1 myeloid cell leukemia 1 0.0822315
UBC ubiquitin C 0.0819857
EIF4A3 eukaryotic translation initiation factor 4A3 0.0780066
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0766504
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0749031
AHR aryl hydrocarbon receptor 0.0736174
TXNRD1 thioredoxin reductase 1 0.0712544
CHD1 chromodomain helicase DNA binding protein 1 0.0703743
TSC22D2 TSC22 domain family, member 2 0.0699094
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0691014
MCTP1 multiple C2 domains, transmembrane 1 0.0688823
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0671949
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0656899
DIAPH1 diaphanous-related formin 1 0.0639503
PGK1 phosphoglycerate kinase 1 0.0616351
SQSTM1 sequestosome 1 0.0611078
STC1 stanniocalcin 1 0.0600053
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0565173
USP9X ubiquitin specific peptidase 9, X-linked 0.0559225
SOD2 superoxide dismutase 2, mitochondrial 0.0558864
NUP58 nucleoporin 58 0.055555
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0550255
TM4SF1 transmembrane 4 L six family member 1 0.0541116
PM20D1 peptidase M20 domain containing 1 0.0540374
ELL2 elongation factor, RNA polymerase II, 2 0.0531518
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.052451
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.051488
KDM3A lysine (K)-specific demethylase 3A 0.0512686
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0507904
SMAD2 SMAD family member 2 0.0505308
LAMA1 laminin, alpha 1 0.0485424
CXCL8 chemokine (C-X-C motif) ligand 8 0.0482438
TOP1 topoisomerase (DNA) I 0.0480034
CCNL1 cyclin L1 0.0475334
EEF2 eukaryotic translation elongation factor 2 0.0467674
TFRC transferrin receptor 0.0452603
ATAD1 ATPase family, AAA domain containing 1 0.0444397
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0443225
WAC WW domain containing adaptor with coiled-coil 0.042662
PTPRM protein tyrosine phosphatase, receptor type, M 0.0423102
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0419136
LDHA lactate dehydrogenase A 0.0411859
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0410513
TRIO trio Rho guanine nucleotide exchange factor 0.0409034
FMNL2 formin-like 2 0.0408374
KDM6A lysine (K)-specific demethylase 6A 0.0407313
BZW1 basic leucine zipper and W2 domains 1 0.0403084
BMERB1 bMERB domain containing 1 0.0397694
ANXA5 annexin A5 0.0392849
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0392689
CAMTA1 calmodulin binding transcription activator 1 0.0389732
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0375951
EIF4A1 eukaryotic translation initiation factor 4A1 0.03622
ARL5B ADP-ribosylation factor-like 5B 0.035785
BMP6 bone morphogenetic protein 6 0.0356697
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0355186
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0354669
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0354257
ATP13A3 ATPase type 13A3 0.0352428
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0352041
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0348632
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0342855
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.034071
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0340008
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336144
PDIA6 protein disulfide isomerase family A, member 6 0.033481
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334758
DUSP5 dual specificity phosphatase 5 0.0329385
CRY1 cryptochrome circadian clock 1 0.0324889
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0324526
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0320072
PTEN phosphatase and tensin homolog 0.0319105
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0318759
ETV3 ets variant 3 0.0318475
PNPLA8 patatin-like phospholipase domain containing 8 0.0313372
RHEB Ras homolog enriched in brain 0.0311869
NCAM1 neural cell adhesion molecule 1 0.0307177
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0296348
DDIT4 DNA-damage-inducible transcript 4 0.0296245
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0295038
ARHGAP26 Rho GTPase activating protein 26 0.0292454
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0290415
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0289938
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0288869
PUM2 pumilio RNA-binding family member 2 0.0287651
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0283022
PKM pyruvate kinase, muscle 0.0282789

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113539
TMSB10 thymosin beta 10 -0.0937135
PTMA prothymosin, alpha -0.0832115
EFNA5 ephrin-A5 -0.0786099
FTL ferritin, light polypeptide -0.0568014
RPLP1 ribosomal protein, large, P1 -0.0540934
TPT1 tumor protein, translationally-controlled 1 -0.0511022
RPL12 ribosomal protein L12 -0.0465113
RPS19 ribosomal protein S19 -0.044785
ISG15 ISG15 ubiquitin-like modifier -0.0433246
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0431855
RPLP2 ribosomal protein, large, P2 -0.0414233
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.039466
NRCAM neuronal cell adhesion molecule -0.0362657
RPLP0 ribosomal protein, large, P0 -0.0353546
TRA2A transformer 2 alpha homolog (Drosophila) -0.0344424
RPS3 ribosomal protein S3 -0.0336266
RPL26 ribosomal protein L26 -0.0330714
RPS27A ribosomal protein S27a -0.0319353
RPL31 ribosomal protein L31 -0.0317843
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0306659
RPL35A ribosomal protein L35a -0.0306094
SMYD3 SET and MYND domain containing 3 -0.0304992
RPL9 ribosomal protein L9 -0.030256
S100A6 S100 calcium binding protein A6 -0.0296551
RPL36 ribosomal protein L36 -0.0281609
RPS24 ribosomal protein S24 -0.0271231
NEK7 NIMA-related kinase 7 -0.0267833
S100A10 S100 calcium binding protein A10 -0.0267296
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -0.0266957
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0265269
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0260204
S100A9 S100 calcium binding protein A9 -0.0256627
MYOF myoferlin -0.0253819
PALLD palladin, cytoskeletal associated protein -0.025094
RPS8 ribosomal protein S8 -0.0250668
RPL23 ribosomal protein L23 -0.0245189
CD83 CD83 molecule -0.0244916
RGS2 regulator of G-protein signaling 2 -0.0244892
RPL37A ribosomal protein L37a -0.0240042
CD109 CD109 molecule -0.0239956
RPL35 ribosomal protein L35 -0.0238239
ANXA1 annexin A1 -0.0235777
RTN4 reticulon 4 -0.0229632
RPL19 ribosomal protein L19 -0.0225185
RPS23 ribosomal protein S23 -0.0224432
RPS21 ribosomal protein S21 -0.0223773
RPS6 ribosomal protein S6 -0.0222856
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0221774
RPS12 ribosomal protein S12 -0.0219541
VIM vimentin -0.0218682
SSH2 slingshot protein phosphatase 2 -0.0216781
PTGR1 prostaglandin reductase 1 -0.0211157
RPL32 ribosomal protein L32 -0.0210578
PHF21A PHD finger protein 21A -0.0210256
B2M beta-2-microglobulin -0.0209761
RPL34 ribosomal protein L34 -0.0209477
DST dystonin -0.0208274
PDGFA platelet-derived growth factor alpha polypeptide -0.020518
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0205178
RPS29 ribosomal protein S29 -0.0204582
ATP5F1E ATP synthase F1 subunit epsilon -0.0204354
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0202132
MON2 MON2 homolog (S. cerevisiae) -0.0199093
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0197267
MT2A metallothionein 2A -0.0196168
WDFY2 WD repeat and FYVE domain containing 2 -0.0193718
RPS13 ribosomal protein S13 -0.017668
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0173438
ACBD3 acyl-CoA binding domain containing 3 -0.0170466
RPS14 ribosomal protein S14 -0.0167723
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0166122
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0165316
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0164658
METTL15 methyltransferase like 15 -0.016303
RPL18 ribosomal protein L18 -0.0161377
PCBP3 poly(rC) binding protein 3 -0.0161057
HELZ helicase with zinc finger -0.0157608
GSTP1 glutathione S-transferase pi 1 -0.0156907
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0156756
HEATR1 HEAT repeat containing 1 -0.0153968
LMNA lamin A/C -0.015377
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0153477
SLF1 SMC5-SMC6 complex localization factor 1 -0.015269
IFRD1 interferon-related developmental regulator 1 -0.0152348
RAI1 retinoic acid induced 1 -0.0150681
RPS4X ribosomal protein S4, X-linked -0.0150565
COG5 component of oligomeric golgi complex 5 -0.0145821
RPL36A ribosomal protein L36a -0.0144521
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0144498
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0143693
NAP1L1 nucleosome assembly protein 1-like 1 -0.014334
IGFBP3 insulin-like growth factor binding protein 3 -0.0142975
RNF24 ring finger protein 24 -0.0142967
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0142549
GPC6 glypican 6 -0.0140574
RPL13A ribosomal protein L13a -0.0139479
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0139469
RPL38 ribosomal protein L38 -0.0138806
ZC3H3 zinc finger CCCH-type containing 3 -0.0138647