| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Digitoxin perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Digitoxin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.324841 |
| PTMA | prothymosin, alpha | 0.247084 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.201456 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.174528 |
| JUN | jun proto-oncogene | 0.162109 |
| IFRD1 | interferon-related developmental regulator 1 | 0.150679 |
| SPAG9 | sperm associated antigen 9 | 0.141991 |
| VGF | VGF nerve growth factor inducible | 0.138495 |
| LMNA | lamin A/C | 0.126244 |
| DSCAM | Down syndrome cell adhesion molecule | 0.122448 |
| APP | amyloid beta (A4) precursor protein | 0.112681 |
| WAC | WW domain containing adaptor with coiled-coil | 0.111668 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103624 |
| UBC | ubiquitin C | 0.103017 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.102996 |
| SQSTM1 | sequestosome 1 | 0.101197 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0967774 |
| INSIG1 | insulin induced gene 1 | 0.0954921 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0935522 |
| ENO1 | enolase 1, (alpha) | 0.0917472 |
| YTHDC1 | YTH domain containing 1 | 0.0885582 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0854171 |
| RPS27A | ribosomal protein S27a | 0.0829653 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0769717 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.073306 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0721972 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.072035 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0715415 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0713867 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0667136 |
| SIK3 | SIK family kinase 3 | 0.0667076 |
| NDRG1 | N-myc downstream regulated 1 | 0.0638457 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0635428 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0622741 |
| TMSB10 | thymosin beta 10 | 0.0609675 |
| FN1 | fibronectin 1 | 0.0593373 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0571543 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0549198 |
| FTL | ferritin, light polypeptide | 0.0547305 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0545796 |
| LDHA | lactate dehydrogenase A | 0.0543442 |
| CCNY | cyclin Y | 0.0542011 |
| PTK2 | protein tyrosine kinase 2 | 0.0513372 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0508324 |
| H3-3B | H3.3 histone B | 0.0498554 |
| RPLP2 | ribosomal protein, large, P2 | 0.0473091 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0468376 |
| WDR45B | WD repeat domain 45B | 0.0457202 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.044112 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0433334 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0415536 |
| OGA | O-GlcNAcase | 0.0403155 |
| MATR3 | matrin 3 | 0.0400989 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0393814 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0386432 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0355605 |
| ZNF207 | zinc finger protein 207 | 0.0344187 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0323228 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0319564 |
| PCBP2 | poly(rC) binding protein 2 | 0.0319469 |
| ACTG1 | actin gamma 1 | 0.03181 |
| GPHN | gephyrin | 0.0298121 |
| RPL23 | ribosomal protein L23 | 0.0285397 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0284401 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.028319 |
| TMSB4X | thymosin beta 4, X-linked | 0.0282274 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0271529 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0267099 |
| RPS3 | ribosomal protein S3 | 0.02582 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0253823 |
| RBM39 | RNA binding motif protein 39 | 0.0252248 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0251598 |
| MEIS1 | Meis homeobox 1 | 0.0250544 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.022244 |
| CALR | calreticulin | 0.0218794 |
| PHIP | pleckstrin homology domain interacting protein | 0.0218422 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.020909 |
| RNF145 | ring finger protein 145 | 0.0191179 |
| RPLP1 | ribosomal protein, large, P1 | 0.0178222 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0173901 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0172436 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0168828 |
| TPM3 | tropomyosin 3 | 0.0164521 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0159909 |
| PKM | pyruvate kinase, muscle | 0.0154926 |
| SNX9 | sorting nexin 9 | 0.0148789 |
| FAT1 | FAT atypical cadherin 1 | 0.0141108 |
| ZNF292 | zinc finger protein 292 | 0.0137239 |
| RLF | rearranged L-myc fusion | 0.0136245 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0122102 |
| RPL19 | ribosomal protein L19 | 0.0120873 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0115648 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00992686 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0095015 |
| YBX1 | Y box binding protein 1 | 0.00856968 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.00791532 |
| INHBA | inhibin, beta A | 0.00778174 |
| NF1 | neurofibromin 1 | 0.00754049 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0071796 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.00701625 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.125361 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.114996 |
| SMYD3 | SET and MYND domain containing 3 | -0.103256 |
| EGFR | epidermal growth factor receptor | -0.10294 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.101788 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.10013 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0982451 |
| PRKCA | protein kinase C, alpha | -0.0959086 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0849961 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0791955 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0787329 |
| LOXL2 | lysyl oxidase-like 2 | -0.0765249 |
| NAV1 | neuron navigator 1 | -0.0740076 |
| AHNAK | AHNAK nucleoprotein | -0.0731804 |
| CCNI | cyclin I | -0.0718542 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.070416 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0681849 |
| MAP4 | microtubule-associated protein 4 | -0.0676578 |
| RAD51B | RAD51 paralog B | -0.0651841 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0650127 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0645658 |
| OSMR | oncostatin M receptor | -0.0631381 |
| MYO1E | myosin IE | -0.0622787 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0616203 |
| SETD5 | SET domain containing 5 | -0.0616019 |
| HMGA2 | high mobility group AT-hook 2 | -0.0592626 |
| FAM13A | family with sequence similarity 13, member A | -0.059004 |
| GPC6 | glypican 6 | -0.0589207 |
| MAP1B | microtubule-associated protein 1B | -0.0582514 |
| FMNL2 | formin-like 2 | -0.0580007 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0576479 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0559352 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0549087 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0541297 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0537133 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0518854 |
| PDE10A | phosphodiesterase 10A | -0.0515172 |
| EFNA5 | ephrin-A5 | -0.0514595 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0512317 |
| PRELID2 | PRELI domain containing 2 | -0.050521 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0489546 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0470131 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0466408 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0458575 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0453238 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0451278 |
| TENM3 | teneurin transmembrane protein 3 | -0.0447227 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0434233 |
| PGK1 | phosphoglycerate kinase 1 | -0.0423263 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0409379 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0390574 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0389405 |
| TXNRD1 | thioredoxin reductase 1 | -0.0387878 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0377266 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0369921 |
| B2M | beta-2-microglobulin | -0.0367556 |
| HLA-B | major histocompatibility complex, class I, B | -0.036638 |
| HBS1L | HBS1-like translational GTPase | -0.0364507 |
| RORA | RAR-related orphan receptor A | -0.0361141 |
| INTS6 | integrator complex subunit 6 | -0.035628 |
| USP34 | ubiquitin specific peptidase 34 | -0.0349483 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.03494 |
| ATXN1 | ataxin 1 | -0.034803 |
| JMJD1C | jumonji domain containing 1C | -0.0344911 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0344526 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0338459 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0335333 |
| RPS12 | ribosomal protein S12 | -0.0332533 |
| SBF2 | SET binding factor 2 | -0.0330009 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0320329 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0309043 |
| RPS6 | ribosomal protein S6 | -0.0308101 |
| ASPH | aspartate beta-hydroxylase | -0.0307627 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0305664 |
| MYOF | myoferlin | -0.0298078 |
| RPL37A | ribosomal protein L37a | -0.0295456 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0285588 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0277177 |
| MT2A | metallothionein 2A | -0.0261438 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0259786 |
| BRD4 | bromodomain containing 4 | -0.0252754 |
| CERT1 | ceramide transporter 1 | -0.0237506 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0234622 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0233987 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0232884 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0228538 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0228304 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0220703 |
| NFIA | nuclear factor I/A | -0.0218316 |
| CADM2 | cell adhesion molecule 2 | -0.0217392 |
| ETNK1 | ethanolamine kinase 1 | -0.0212776 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0210027 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0209297 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0207226 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0204891 |
| STC1 | stanniocalcin 1 | -0.0202527 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0201842 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0200269 |
| ANXA2 | annexin A2 | -0.019068 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0190287 |
