Digitoxin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.147357
SLC38A2 solute carrier family 38, member 2 0.132662
ECT2 epithelial cell transforming 2 0.118168
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.114594
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0981441
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0900104
CAMTA1 calmodulin binding transcription activator 1 0.0853517
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0823096
ENO1 enolase 1, (alpha) 0.0803237
TXNRD1 thioredoxin reductase 1 0.0730647
CENPF centromere protein F, 350/400kDa 0.0671538
NBAS neuroblastoma amplified sequence 0.0657775
GOLGA4 golgin A4 0.0654476
ADAM10 ADAM metallopeptidase domain 10 0.0625664
MKI67 marker of proliferation Ki-67 0.0616728
UBC ubiquitin C 0.0604818
ELOVL5 ELOVL fatty acid elongase 5 0.0604101
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0596753
LOC112694756 uncharaterized LOC112694756 0.0574926
ZCCHC7 zinc finger, CCHC domain containing 7 0.0562106
NUP58 nucleoporin 58 0.0550811
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0546717
RBM39 RNA binding motif protein 39 0.0542729
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0539845
TOP2A topoisomerase (DNA) II alpha 170kDa 0.053846
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0535247
RTN4 reticulon 4 0.0530756
CALU calumenin 0.048725
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0474375
HSPA8 heat shock 70kDa protein 8 0.0462078
SOX6 SRY (sex determining region Y)-box 6 0.0457931
ANLN anillin, actin binding protein 0.045356
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0452164
SEC31A SEC31 homolog A (S. cerevisiae) 0.0451958
DSCAM Down syndrome cell adhesion molecule 0.0449986
QKI QKI, KH domain containing, RNA binding 0.0449506
TPX2 TPX2, microtubule-associated 0.0439323
BMP2K BMP2 inducible kinase 0.0437529
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0430846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0413284
KDM3A lysine (K)-specific demethylase 3A 0.0412195
COPA coatomer protein complex, subunit alpha 0.039891
ANXA1 annexin A1 0.0397809
HJURP Holliday junction recognition protein 0.0397614
ZFAND3 zinc finger, AN1-type domain 3 0.0389918
SRRM2 serine/arginine repetitive matrix 2 0.038968
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0388453
FNDC3B fibronectin type III domain containing 3B 0.0386468
TMF1 TATA element modulatory factor 1 0.0386319
KIF5B kinesin family member 5B 0.0385936
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0382632
CKAP5 cytoskeleton associated protein 5 0.0377347
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0376837
APP amyloid beta (A4) precursor protein 0.0374158
SRP54 signal recognition particle 54kDa 0.0371676
BIRC6 baculoviral IAP repeat containing 6 0.0370118
AHNAK AHNAK nucleoprotein 0.0364692
MYOF myoferlin 0.0360342
TM9SF3 transmembrane 9 superfamily member 3 0.0357582
CCNY cyclin Y 0.0354483
COPB1 coatomer protein complex, subunit beta 1 0.0352218
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0351327
WDR43 WD repeat domain 43 0.0346502
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0345956
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.034424
COG6 component of oligomeric golgi complex 6 0.0342136
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.034081
FXR1 fragile X mental retardation, autosomal homolog 1 0.0340474
PTK2 protein tyrosine kinase 2 0.0334779
RCOR1 REST corepressor 1 0.0333769
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0333479
SUCO SUN domain containing ossification factor 0.0331778
TPD52 tumor protein D52 0.0329763
DIAPH3 diaphanous-related formin 3 0.0328371
HDLBP high density lipoprotein binding protein 0.0326694
PARD3 par-3 family cell polarity regulator 0.0326367
ZMYM2 zinc finger, MYM-type 2 0.0324377
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0322852
YAP1 Yes-associated protein 1 0.0321966
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0320817
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0318717
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0318211
EML4 echinoderm microtubule associated protein like 4 0.0314713
ENO2 enolase 2 (gamma, neuronal) 0.0313378
SMNDC1 survival motor neuron domain containing 1 0.0313328
PICALM phosphatidylinositol binding clathrin assembly protein 0.0310465
HM13 histocompatibility (minor) 13 0.0305946
ZNF644 zinc finger protein 644 0.0305695
DIAPH1 diaphanous-related formin 1 0.0304547
TENT4A terminal nucleotidyltransferase 4A 0.030411
NUP153 nucleoporin 153kDa 0.0303854
EEF2 eukaryotic translation elongation factor 2 0.0303771
COG5 component of oligomeric golgi complex 5 0.0302179
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0301256
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0299742
CPED1 cadherin-like and PC-esterase domain containing 1 0.0299218
PIBF1 progesterone immunomodulatory binding factor 1 0.0298009
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0293883
SMC4 structural maintenance of chromosomes 4 0.0293762
GPR107 G protein-coupled receptor 107 0.0289608

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.26691
RPS6 ribosomal protein S6 -0.118105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110713
TPT1 tumor protein, translationally-controlled 1 -0.104261
VCL vinculin -0.102438
RPL35A ribosomal protein L35a -0.0924238
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0907186
FOXP1 forkhead box P1 -0.0808078
RPLP1 ribosomal protein, large, P1 -0.0768816
SQSTM1 sequestosome 1 -0.0709821
RPS19 ribosomal protein S19 -0.0707998
TMSB10 thymosin beta 10 -0.0649938
RPS8 ribosomal protein S8 -0.0638231
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0616395
RAB7A RAB7A, member RAS oncogene family -0.0602291
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0583259
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0559247
RPLP2 ribosomal protein, large, P2 -0.0549394
RPL19 ribosomal protein L19 -0.0545841
RPL12 ribosomal protein L12 -0.0528614
HDAC9 histone deacetylase 9 -0.052391
RPLP0 ribosomal protein, large, P0 -0.0499467
RPL9 ribosomal protein L9 -0.0494867
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0484169
S100A4 S100 calcium binding protein A4 -0.0467539
RPL11 ribosomal protein L11 -0.0446334
RPS13 ribosomal protein S13 -0.0441083
RPS23 ribosomal protein S23 -0.0433416
RPL34 ribosomal protein L34 -0.0430909
B2M beta-2-microglobulin -0.0430303
GADD45B growth arrest and DNA-damage-inducible, beta -0.04229
ZMYND8 zinc finger, MYND-type containing 8 -0.0419285
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.041923
RPS29 ribosomal protein S29 -0.0404124
MT2A metallothionein 2A -0.0395418
RPL36 ribosomal protein L36 -0.0391887
RPS12 ribosomal protein S12 -0.0389949
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0389068
RPL23 ribosomal protein L23 -0.0383729
PRDX2 peroxiredoxin 2 -0.0380806
EIF1 eukaryotic translation initiation factor 1 -0.038073
PFN1 profilin 1 -0.037748
ACTG1 actin gamma 1 -0.0362715
S100A6 S100 calcium binding protein A6 -0.0362366
RPS16 ribosomal protein S16 -0.0351078
PDGFC platelet derived growth factor C -0.0343628
PDE4B phosphodiesterase 4B, cAMP-specific -0.0342711
FHIT fragile histidine triad -0.0341536
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0340886
RPL7A ribosomal protein L7a -0.0339216
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0332909
HLA-B major histocompatibility complex, class I, B -0.0330932
RPL37A ribosomal protein L37a -0.0329097
RPL30 ribosomal protein L30 -0.0325579
S100A9 S100 calcium binding protein A9 -0.0325525
ANK2 ankyrin 2, neuronal -0.0324071
RPL31 ribosomal protein L31 -0.0323717
RPL32 ribosomal protein L32 -0.0320752
RPS25 ribosomal protein S25 -0.0316919
RPL28 ribosomal protein L28 -0.0314968
RPS14 ribosomal protein S14 -0.0311113
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0309241
DOCK3 dedicator of cytokinesis 3 -0.0307646
ZNFX1 zinc finger, NFX1-type containing 1 -0.0306593
RPS21 ribosomal protein S21 -0.0304512
LOC102724023 ES1 protein homolog, mitochondrial -0.0304379
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0295902
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0295723
RPL26 ribosomal protein L26 -0.0290072
TXNIP thioredoxin interacting protein -0.0287036
SON SON DNA binding protein -0.0286395
RAD51B RAD51 paralog B -0.0282039
IFI16 interferon, gamma-inducible protein 16 -0.0274857
IFI6 interferon, alpha-inducible protein 6 -0.0274135
RPS15 ribosomal protein S15 -0.0273347
RACK1 receptor for activated C kinase 1 -0.0270334
RPS27 ribosomal protein S27 -0.026496
TBC1D5 TBC1 domain family, member 5 -0.0263772
RIGI RNA sensor RIG-I -0.0262341
TMSB4X thymosin beta 4, X-linked -0.0261487
VIM vimentin -0.0261211
RPS17 ribosomal protein S17 -0.0259371
RPL35 ribosomal protein L35 -0.0257951
ARL4C ADP-ribosylation factor-like 4C -0.0257357
HSPB1 heat shock 27kDa protein 1 -0.0256053
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0255411
PIWIL1 piwi-like RNA-mediated gene silencing 1 -0.0251592
GLI3 GLI family zinc finger 3 -0.0250627
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0248649
SSBP2 single-stranded DNA binding protein 2 -0.0246659
BPTF bromodomain PHD finger transcription factor -0.0246593
RPL38 ribosomal protein L38 -0.0246349
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.024528
BBS9 Bardet-Biedl syndrome 9 -0.0243722
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0243078
GPHN gephyrin -0.0237876
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0236653
RPS20 ribosomal protein S20 -0.0235629
CAMKMT calmodulin-lysine N-methyltransferase -0.0235392
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0235084