Digitoxin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.173822
SOD2 superoxide dismutase 2, mitochondrial 0.168165
NAMPT nicotinamide phosphoribosyltransferase 0.141369
FN1 fibronectin 1 0.141075
NAV2 neuron navigator 2 0.109718
MYH9 myosin, heavy chain 9, non-muscle 0.108154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0965231
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0885443
CD44 CD44 molecule (Indian blood group) 0.0875549
EEF2 eukaryotic translation elongation factor 2 0.0862693
ATP13A3 ATPase type 13A3 0.0826921
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0826082
UBC ubiquitin C 0.0807269
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0733666
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.072278
PGK1 phosphoglycerate kinase 1 0.0720115
SMAD3 SMAD family member 3 0.0717813
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0687891
USP9X ubiquitin specific peptidase 9, X-linked 0.0670243
TOP2A topoisomerase (DNA) II alpha 170kDa 0.066235
ANLN anillin, actin binding protein 0.0651347
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.064755
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0603805
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.05964
CENPF centromere protein F, 350/400kDa 0.0591921
COL6A3 collagen, type VI, alpha 3 0.0587364
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0579579
THBS1 thrombospondin 1 0.0574753
SPAG9 sperm associated antigen 9 0.0537603
APP amyloid beta (A4) precursor protein 0.0537023
MKI67 marker of proliferation Ki-67 0.0533676
ZNF292 zinc finger protein 292 0.0533144
OGA O-GlcNAcase 0.0532716
KDM3A lysine (K)-specific demethylase 3A 0.049668
ELL2 elongation factor, RNA polymerase II, 2 0.046914
AFDN afadin, adherens junction formation factor 0.0466348
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0462725
TRIO trio Rho guanine nucleotide exchange factor 0.0455945
TSC22D2 TSC22 domain family, member 2 0.0454424
WTAP Wilms tumor 1 associated protein 0.0451556
RND3 Rho family GTPase 3 0.0438255
LAMP2 lysosomal-associated membrane protein 2 0.0432535
UGCG UDP-glucose ceramide glucosyltransferase 0.0430007
ANXA2 annexin A2 0.0429692
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0429318
STC1 stanniocalcin 1 0.0418737
PCBP2 poly(rC) binding protein 2 0.0417045
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402189
KYNU kynureninase 0.0388417
PPARD peroxisome proliferator-activated receptor delta 0.037423
CRY1 cryptochrome circadian clock 1 0.0374028
KIF4A kinesin family member 4A 0.0372478
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0371146
AHR aryl hydrocarbon receptor 0.0369823
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0354241
ARRDC3 arrestin domain containing 3 0.0353174
UBA6 ubiquitin-like modifier activating enzyme 6 0.0350219
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0346487
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0339894
HELZ helicase with zinc finger 0.0337638
TNIP1 TNFAIP3 interacting protein 1 0.0334688
RBM39 RNA binding motif protein 39 0.0331879
NPEPPS aminopeptidase puromycin sensitive 0.033013
BASP1 brain abundant, membrane attached signal protein 1 0.0327113
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0309124
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.030876
VCAN versican 0.0308634
CKAP5 cytoskeleton associated protein 5 0.0306623
SNX9 sorting nexin 9 0.0304677
PTBP3 polypyrimidine tract binding protein 3 0.0301272
CSDE1 cold shock domain containing E1, RNA-binding 0.0299282
DENND5A DENN/MADD domain containing 5A 0.0298837
MBNL1 muscleblind-like splicing regulator 1 0.029821
STAG2 stromal antigen 2 0.0296901
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0295389
KMT2E lysine (K)-specific methyltransferase 2E 0.0293028
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0291786
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0291374
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0288426
AKAP13 A kinase (PRKA) anchor protein 13 0.0286023
EZR ezrin 0.0280445
NONO non-POU domain containing, octamer-binding 0.0276907
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0273527
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0273325
ENO1 enolase 1, (alpha) 0.027319
LCORL ligand dependent nuclear receptor corepressor-like 0.0272388
ESYT2 extended synaptotagmin-like protein 2 0.0272103
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0271414
FMNL2 formin-like 2 0.0270377
MARCHF6 membrane associated ring-CH-type finger 6 0.0269691
EIF4A1 eukaryotic translation initiation factor 4A1 0.0267864
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0265167
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0264632
PKM pyruvate kinase, muscle 0.0264107
CADM1 cell adhesion molecule 1 0.0261279
GOLGA4 golgin A4 0.0258503
WEE1 WEE1 G2 checkpoint kinase 0.0257208
DSCAM Down syndrome cell adhesion molecule 0.0255135
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0254552
DUSP10 dual specificity phosphatase 10 0.0253828

decreased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B -0.13513
MT2A metallothionein 2A -0.100103
TPT1 tumor protein, translationally-controlled 1 -0.0998869
FTL ferritin, light polypeptide -0.0873656
VIM vimentin -0.0860304
RPS6 ribosomal protein S6 -0.0836107
TMSB10 thymosin beta 10 -0.069414
RPLP2 ribosomal protein, large, P2 -0.0669669
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0632718
RPL35A ribosomal protein L35a -0.0632409
IER3 immediate early response 3 -0.0606195
PTMA prothymosin, alpha -0.0529906
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0527831
RPS8 ribosomal protein S8 -0.0512373
RPLP1 ribosomal protein, large, P1 -0.0505092
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0504517
RPS12 ribosomal protein S12 -0.0500087
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0497466
RPS23 ribosomal protein S23 -0.0495956
FRMD4A FERM domain containing 4A -0.0465183
RPS24 ribosomal protein S24 -0.044279
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0435772
RPL37A ribosomal protein L37a -0.0415651
RPL26 ribosomal protein L26 -0.0415122
CDH13 cadherin 13 -0.040953
SQSTM1 sequestosome 1 -0.0406217
RPS3 ribosomal protein S3 -0.0403128
EGR1 early growth response 1 -0.0399658
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0398406
RPS19 ribosomal protein S19 -0.0392786
RPS13 ribosomal protein S13 -0.0384004
RPL36A ribosomal protein L36a -0.0373628
RPL9 ribosomal protein L9 -0.0364262
IFITM3 interferon induced transmembrane protein 3 -0.0362517
B2M beta-2-microglobulin -0.0361109
VCL vinculin -0.0356732
HLA-A major histocompatibility complex, class I, A -0.0344121
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.034348
RPL36 ribosomal protein L36 -0.0343106
RPL23 ribosomal protein L23 -0.0342014
RPL31 ribosomal protein L31 -0.0341281
ZMYND8 zinc finger, MYND-type containing 8 -0.0340697
SP100 SP100 nuclear antigen -0.0336621
RPS21 ribosomal protein S21 -0.0333416
RPL7A ribosomal protein L7a -0.0327016
RPL38 ribosomal protein L38 -0.0310955
CTSD cathepsin D -0.0306527
S100A9 S100 calcium binding protein A9 -0.0303331
RPL11 ribosomal protein L11 -0.0300638
IFI16 interferon, gamma-inducible protein 16 -0.0298003
IFI6 interferon, alpha-inducible protein 6 -0.0294087
RAD51B RAD51 paralog B -0.0291635
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0290342
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0288036
RPS14 ribosomal protein S14 -0.0287342
HDAC9 histone deacetylase 9 -0.0286308
RPL12 ribosomal protein L12 -0.0285078
RPS10 ribosomal protein S10 -0.0284216
RPS25 ribosomal protein S25 -0.028326
RPS29 ribosomal protein S29 -0.0276415
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0274862
RPL19 ribosomal protein L19 -0.0271343
DIAPH2 diaphanous-related formin 2 -0.0263713
RIGI RNA sensor RIG-I -0.0261761
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0259288
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0259038
AKAP12 A kinase (PRKA) anchor protein 12 -0.0258966
EIF1 eukaryotic translation initiation factor 1 -0.024635
IFIH1 interferon induced with helicase C domain 1 -0.0246158
RPL35 ribosomal protein L35 -0.0238236
GPC6 glypican 6 -0.0234579
ACTG1 actin gamma 1 -0.0231579
BTG1 B-cell translocation gene 1, anti-proliferative -0.0230416
STC2 stanniocalcin 2 -0.0227817
RAB7A RAB7A, member RAS oncogene family -0.0227279
RPL34 ribosomal protein L34 -0.0223786
INTS6 integrator complex subunit 6 -0.022052
EGFR epidermal growth factor receptor -0.0218213
RPS16 ribosomal protein S16 -0.0217754
TIMP2 TIMP metallopeptidase inhibitor 2 -0.021717
ISG15 ISG15 ubiquitin-like modifier -0.0216519
RPL28 ribosomal protein L28 -0.0213689
LOC102724023 ES1 protein homolog, mitochondrial -0.021082
ASPH aspartate beta-hydroxylase -0.0208747
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0207817
RPL27 ribosomal protein L27 -0.0207669
RPS27 ribosomal protein S27 -0.0203496
SOX5 SRY (sex determining region Y)-box 5 -0.0200206
RPL37 ribosomal protein L37 -0.0194724
C3 complement component 3 -0.0193369
RPS27A ribosomal protein S27a -0.0193252
DLG1 discs, large homolog 1 (Drosophila) -0.0192268
PMP22 peripheral myelin protein 22 -0.0191878
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0191467
RNF213 ring finger protein 213 -0.0191317
FBXO11 F-box protein 11 -0.019076
RPL27A ribosomal protein L27a -0.0189848
RPS17 ribosomal protein S17 -0.0188898
DDIT3 DNA-damage-inducible transcript 3 -0.0188066
TMEM132D transmembrane protein 132D -0.0187575