Digitoxin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.302292
MT2A metallothionein 2A 0.201966
TMSB10 thymosin beta 10 0.197956
UBC ubiquitin C 0.178393
SOD2 superoxide dismutase 2, mitochondrial 0.105379
FAM13A family with sequence similarity 13, member A 0.101468
CXCL8 chemokine (C-X-C motif) ligand 8 0.0971863
STC1 stanniocalcin 1 0.0936695
TRIO trio Rho guanine nucleotide exchange factor 0.0901714
PTMA prothymosin, alpha 0.0881174
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0828711
SDC4 syndecan 4 0.0817973
SPAG9 sperm associated antigen 9 0.0816841
ELL2 elongation factor, RNA polymerase II, 2 0.0797603
ERRFI1 ERBB receptor feedback inhibitor 1 0.0780641
NAMPT nicotinamide phosphoribosyltransferase 0.0777361
COL1A1 collagen, type I, alpha 1 0.0727644
CALU calumenin 0.0720558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0695567
ARRDC3 arrestin domain containing 3 0.0693579
ATP13A3 ATPase type 13A3 0.0686402
CADM1 cell adhesion molecule 1 0.0676134
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0651335
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0650902
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0650074
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0645138
ANLN anillin, actin binding protein 0.06328
MYH9 myosin, heavy chain 9, non-muscle 0.0622573
INSIG1 insulin induced gene 1 0.0587578
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0577424
AHNAK AHNAK nucleoprotein 0.0572339
B2M beta-2-microglobulin 0.0561754
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0557994
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0556609
PDIA3 protein disulfide isomerase family A, member 3 0.0552391
RNF145 ring finger protein 145 0.0550692
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0546321
RBM25 RNA binding motif protein 25 0.0510015
JUN jun proto-oncogene 0.0505433
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0481891
MED13L mediator complex subunit 13-like 0.0473216
SETD5 SET domain containing 5 0.0462241
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.046006
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0456787
KDM3A lysine (K)-specific demethylase 3A 0.0456023
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.045262
EEF2 eukaryotic translation elongation factor 2 0.0448117
CD44 CD44 molecule (Indian blood group) 0.0443597
MATR3 matrin 3 0.0442492
MT1X metallothionein 1X 0.0442249
EIF1 eukaryotic translation initiation factor 1 0.0436334
DSCAM Down syndrome cell adhesion molecule 0.043319
YBX1 Y box binding protein 1 0.0426267
IL6 interleukin 6 0.0424874
SMAD3 SMAD family member 3 0.0416782
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0410289
NUP58 nucleoporin 58 0.0401745
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0401156
FTH1 ferritin, heavy polypeptide 1 0.0400752
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0398095
ENO1 enolase 1, (alpha) 0.0391003
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0390885
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0389919
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0388122
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385484
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0384328
HMGB2 high mobility group box 2 0.0383156
FNIP1 folliculin interacting protein 1 0.0382507
ARID4B AT rich interactive domain 4B (RBP1-like) 0.038015
TNIP1 TNFAIP3 interacting protein 1 0.0379709
DDIT4 DNA-damage-inducible transcript 4 0.0374141
PDIA6 protein disulfide isomerase family A, member 6 0.0362892
NIPBL Nipped-B homolog (Drosophila) 0.0362523
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0360662
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0360298
VIM vimentin 0.0359453
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0358739
ITGAV integrin, alpha V 0.0356993
RNF24 ring finger protein 24 0.0356694
FLNA filamin A, alpha 0.0356546
CDC27 cell division cycle 27 0.0352048
MACF1 microtubule-actin crosslinking factor 1 0.0347402
OGA O-GlcNAcase 0.0342646
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0341818
APP amyloid beta (A4) precursor protein 0.0335001
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0334965
RLF rearranged L-myc fusion 0.033457
THBS1 thrombospondin 1 0.0330965
CUL3 cullin 3 0.0329534
ESYT2 extended synaptotagmin-like protein 2 0.0325283
RICTOR RPTOR independent companion of MTOR, complex 2 0.0321812
HIPK2 homeodomain interacting protein kinase 2 0.0319998
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0316571
UGCG UDP-glucose ceramide glucosyltransferase 0.031583
ZNF207 zinc finger protein 207 0.0312885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0311525
SRRM1 serine/arginine repetitive matrix 1 0.0311494
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0311373
PUM2 pumilio RNA-binding family member 2 0.0309006
HOOK2 hook microtubule-tethering protein 2 0.0308861

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113893
TGFBI transforming growth factor, beta-induced, 68kDa -0.0967907
FN1 fibronectin 1 -0.0622348
PSD3 pleckstrin and Sec7 domain containing 3 -0.0549272
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0547466
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0456348
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0426244
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0414308
VDAC1 voltage-dependent anion channel 1 -0.0395413
GOLGB1 golgin B1 -0.0386114
HM13 histocompatibility (minor) 13 -0.0374252
HMGA2 high mobility group AT-hook 2 -0.0360541
RAD51B RAD51 paralog B -0.0354612
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0325419
RPL35A ribosomal protein L35a -0.0318773
PDIA5 protein disulfide isomerase family A, member 5 -0.0318174
CCNI cyclin I -0.0317241
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.031567
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0310709
ACTN1 actinin, alpha 1 -0.0310429
SMYD3 SET and MYND domain containing 3 -0.0307591
TPM4 tropomyosin 4 -0.0306302
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0306167
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0297422
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0295739
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0287565
TNNC1 troponin C type 1 (slow) -0.0286561
RPL34 ribosomal protein L34 -0.0279667
FHIT fragile histidine triad -0.0278202
TTC17 tetratricopeptide repeat domain 17 -0.0275645
RRBP1 ribosome binding protein 1 -0.0274003
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.02735
AK1 adenylate kinase 1 -0.0270355
RPS14 ribosomal protein S14 -0.0268925
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0265958
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0260083
H3-3B H3.3 histone B -0.0255809
MAGED1 melanoma antigen family D1 -0.0254529
MAP4 microtubule-associated protein 4 -0.0252163
ECE1 endothelin converting enzyme 1 -0.0251741
PTGES2 prostaglandin E synthase 2 -0.0251264
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0250688
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0247481
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0247327
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.0246295
COG6 component of oligomeric golgi complex 6 -0.0245551
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0242415
AFF3 AF4/FMR2 family, member 3 -0.0242058
GOLIM4 golgi integral membrane protein 4 -0.0241417
TGFB1 transforming growth factor, beta 1 -0.0240567
SKAP2 src kinase associated phosphoprotein 2 -0.0239205
RPS21 ribosomal protein S21 -0.0239203
EXOC4 exocyst complex component 4 -0.0234107
WWOX WW domain containing oxidoreductase -0.023251
ZMYND8 zinc finger, MYND-type containing 8 -0.0229694
SP100 SP100 nuclear antigen -0.0229354
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0229056
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0224578
PLD3 phospholipase D family, member 3 -0.0224186
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0223197
ACTG1 actin gamma 1 -0.0223133
BLZF1 basic leucine zipper nuclear factor 1 -0.022055
RARS1 arginyl-tRNA synthetase 1 -0.0220065
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0219796
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0217397
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0217265
TTC3 tetratricopeptide repeat domain 3 -0.0215953
MAML3 mastermind-like 3 (Drosophila) -0.0214622
PRRC1 proline-rich coiled-coil 1 -0.0213984
TNRC6B trinucleotide repeat containing 6B -0.0213011
KPNB1 karyopherin (importin) beta 1 -0.0212946
CSMD2 CUB and Sushi multiple domains 2 -0.0212079
PFN1 profilin 1 -0.0211364
TPT1 tumor protein, translationally-controlled 1 -0.0211291
CST3 cystatin C -0.021069
SELENOS selenoprotein S -0.0210326
DNAH11 dynein, axonemal, heavy chain 11 -0.0209551
GSK3B glycogen synthase kinase 3 beta -0.020941
ZBTB20 zinc finger and BTB domain containing 20 -0.0209011
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0208288
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0208023
FBXL20 F-box and leucine-rich repeat protein 20 -0.0207562
YIPF5 Yip1 domain family, member 5 -0.0206094
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0205024
RPL37 ribosomal protein L37 -0.0204815
NALF1 NALCN channel auxiliary factor 1 -0.0204658
DMXL1 Dmx-like 1 -0.0203993
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0203845
ATG12 autophagy related 12 -0.0203075
HDAC8 histone deacetylase 8 -0.0202955
UGDH UDP-glucose 6-dehydrogenase -0.0202779
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.020187
ELP4 elongator acetyltransferase complex subunit 4 -0.020171
DSTN destrin (actin depolymerizing factor) -0.0200738
EIF5B eukaryotic translation initiation factor 5B -0.0200591
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0200517
KAT6B K(lysine) acetyltransferase 6B -0.0200276
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.020013
SCFD1 sec1 family domain containing 1 -0.020011
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.019989