Digitoxin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Digitoxin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Digitoxin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.381366
CXCL8 chemokine (C-X-C motif) ligand 8 0.19288
NAMPT nicotinamide phosphoribosyltransferase 0.179713
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.131667
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.110062
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109161
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0874719
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0823107
TPR translocated promoter region, nuclear basket protein 0.0818517
UBC ubiquitin C 0.0780441
AHR aryl hydrocarbon receptor 0.0779117
WDR45B WD repeat domain 45B 0.0651259
EREG epiregulin 0.0649322
FNDC3B fibronectin type III domain containing 3B 0.064111
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0621394
RICTOR RPTOR independent companion of MTOR, complex 2 0.0616413
FAT1 FAT atypical cadherin 1 0.0584491
OGA O-GlcNAcase 0.0553567
PRRC2C proline-rich coiled-coil 2C 0.05528
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0549155
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0541498
NUP58 nucleoporin 58 0.0509832
CANX calnexin 0.0496373
TXNRD1 thioredoxin reductase 1 0.0496255
DENND5B DENN/MADD domain containing 5B 0.0484544
CALU calumenin 0.0483495
SMAD3 SMAD family member 3 0.0467397
SOD2 superoxide dismutase 2, mitochondrial 0.0461874
CENPF centromere protein F, 350/400kDa 0.0448525
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0434364
UBE2K ubiquitin-conjugating enzyme E2K 0.0430619
MKI67 marker of proliferation Ki-67 0.0430035
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0429186
RAD21 RAD21 homolog (S. pombe) 0.0425693
KDM3A lysine (K)-specific demethylase 3A 0.0424395
HELZ helicase with zinc finger 0.0419744
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0416469
WAC WW domain containing adaptor with coiled-coil 0.040327
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0400696
ENO1 enolase 1, (alpha) 0.0399912
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0398762
SUCO SUN domain containing ossification factor 0.0395165
TM9SF3 transmembrane 9 superfamily member 3 0.039295
ANXA5 annexin A5 0.0390255
NEK7 NIMA-related kinase 7 0.038624
HILPDA hypoxia inducible lipid droplet-associated 0.0385452
NIPBL Nipped-B homolog (Drosophila) 0.0383391
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.037793
SEC23A Sec23 homolog A (S. cerevisiae) 0.0374785
FAM13A family with sequence similarity 13, member A 0.037176
FRYL FRY-like 0.0371403
PTK2 protein tyrosine kinase 2 0.0365769
FTH1 ferritin, heavy polypeptide 1 0.0359849
ZC3H11A zinc finger CCCH-type containing 11A 0.0357659
MARCHF6 membrane associated ring-CH-type finger 6 0.0355428
COPA coatomer protein complex, subunit alpha 0.0354036
MYO1B myosin IB 0.0354019
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0340394
INSIG2 insulin induced gene 2 0.0339458
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0335854
RUNX1 runt-related transcription factor 1 0.0333635
ANLN anillin, actin binding protein 0.033102
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0330808
RNF145 ring finger protein 145 0.0330562
SPAG9 sperm associated antigen 9 0.0329174
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0325902
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0324208
RBM39 RNA binding motif protein 39 0.0320847
LCORL ligand dependent nuclear receptor corepressor-like 0.0318072
CDC73 cell division cycle 73 0.0316825
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0315926
UBA6 ubiquitin-like modifier activating enzyme 6 0.0314989
ZMYM2 zinc finger, MYM-type 2 0.0309063
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0308173
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0302234
RANBP2 RAN binding protein 2 0.0298084
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0296422
APP amyloid beta (A4) precursor protein 0.0293286
CHD7 chromodomain helicase DNA binding protein 7 0.0292823
RAB1A RAB1A, member RAS oncogene family 0.0288117
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.028564
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0285479
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0284453
QKI QKI, KH domain containing, RNA binding 0.0284319
ZNF292 zinc finger protein 292 0.0282184
MIS18BP1 MIS18 binding protein 1 0.0281568
ODR4 odr-4 GPCR localization factor homolog 0.0277906
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0276761
WBP11 WW domain binding protein 11 0.0276283
YAP1 Yes-associated protein 1 0.0274586
SLC38A2 solute carrier family 38, member 2 0.0274037
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0272919
COG5 component of oligomeric golgi complex 5 0.0269225
EIF4A1 eukaryotic translation initiation factor 4A1 0.0268721
SEPTIN7 septin 7 0.0268171
PICALM phosphatidylinositol binding clathrin assembly protein 0.0266296
AFDN afadin, adherens junction formation factor 0.0266042
MYO6 myosin VI 0.0265613
PARD3 par-3 family cell polarity regulator 0.0265225
VEGFA vascular endothelial growth factor A 0.0263567

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.254696
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144981
NRG1 neuregulin 1 -0.106956
HMGA2 high mobility group AT-hook 2 -0.0981844
ITGA1 integrin, alpha 1 -0.0974615
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0751113
FTL ferritin, light polypeptide -0.061812
IFI27 interferon, alpha-inducible protein 27 -0.0608296
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0606804
SYT1 synaptotagmin I -0.0598713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0589007
TMSB10 thymosin beta 10 -0.0585964
VIM vimentin -0.0571469
VCL vinculin -0.0554062
ASPH aspartate beta-hydroxylase -0.0550377
MT2A metallothionein 2A -0.0509314
TMEM156 transmembrane protein 156 -0.048528
PTMA prothymosin, alpha -0.0444883
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0444227
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0422482
LOC102724023 ES1 protein homolog, mitochondrial -0.0391305
SQSTM1 sequestosome 1 -0.0382959
HLA-B major histocompatibility complex, class I, B -0.0382049
GLIS3 GLIS family zinc finger 3 -0.037691
SOX4 SRY (sex determining region Y)-box 4 -0.0370334
NTN4 netrin 4 -0.036566
RPS19 ribosomal protein S19 -0.0356052
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0346847
ACTG1 actin gamma 1 -0.0341553
INSIG1 insulin induced gene 1 -0.034076
RAD51B RAD51 paralog B -0.033642
RPLP1 ribosomal protein, large, P1 -0.0335775
DNAH5 dynein, axonemal, heavy chain 5 -0.0312637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0306087
AKAP12 A kinase (PRKA) anchor protein 12 -0.0298878
EGR1 early growth response 1 -0.0296818
RAB7A RAB7A, member RAS oncogene family -0.0291359
GRB10 growth factor receptor-bound protein 10 -0.028865
ETV1 ets variant 1 -0.0286585
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0281384
PDE4D phosphodiesterase 4D, cAMP-specific -0.0280447
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0271365
CXCL2 chemokine (C-X-C motif) ligand 2 -0.0269711
TPT1 tumor protein, translationally-controlled 1 -0.0266833
MAML2 mastermind-like 2 (Drosophila) -0.0264489
RASAL2 RAS protein activator like 2 -0.0257917
RPL37A ribosomal protein L37a -0.0257468
CXCL3 chemokine (C-X-C motif) ligand 3 -0.025714
LIMCH1 LIM and calponin homology domains 1 -0.0254662
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252736
IFI6 interferon, alpha-inducible protein 6 -0.0250116
RPL35A ribosomal protein L35a -0.0248495
MBD5 methyl-CpG binding domain protein 5 -0.0238371
RPS6 ribosomal protein S6 -0.0237911
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0237662
RPLP2 ribosomal protein, large, P2 -0.0235838
GLUL glutamate-ammonia ligase -0.0235123
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0234494
BPTF bromodomain PHD finger transcription factor -0.0232453
NRP1 neuropilin 1 -0.0230496
RPS12 ribosomal protein S12 -0.0229821
BIRC3 baculoviral IAP repeat containing 3 -0.0227398
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0227229
TENM4 teneurin transmembrane protein 4 -0.0226985
RPS27 ribosomal protein S27 -0.02264
MAP1B microtubule-associated protein 1B -0.0225725
RPL9 ribosomal protein L9 -0.0225186
CCL2 chemokine (C-C motif) ligand 2 -0.0225022
ZBTB20 zinc finger and BTB domain containing 20 -0.022134
PELO pelota homolog (Drosophila) -0.0221007
B2M beta-2-microglobulin -0.0218066
FHIT fragile histidine triad -0.0217681
ZMYND8 zinc finger, MYND-type containing 8 -0.0216227
RPL28 ribosomal protein L28 -0.021296
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0209012
RNF213 ring finger protein 213 -0.0208831
EXOC4 exocyst complex component 4 -0.0207847
IFI44L interferon-induced protein 44-like -0.0207748
TSHZ2 teashirt zinc finger homeobox 2 -0.0207746
IFI16 interferon, gamma-inducible protein 16 -0.0204907
NALF1 NALCN channel auxiliary factor 1 -0.020417
MX2 MX dynamin-like GTPase 2 -0.0203305
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0202791
IER3 immediate early response 3 -0.0201377
DPYD dihydropyrimidine dehydrogenase -0.0200273
SVIL supervillin -0.0197875
SFRP1 secreted frizzled-related protein 1 -0.0197727
RABGAP1L RAB GTPase activating protein 1-like -0.0196911
S100A6 S100 calcium binding protein A6 -0.0195196
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0189093
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0187351
RPL12 ribosomal protein L12 -0.0187021
AHRR aryl-hydrocarbon receptor repressor -0.0186666
TMSB4X thymosin beta 4, X-linked -0.0186204
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0186171
RPLP0 ribosomal protein, large, P0 -0.0184502
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0183966
RIGI RNA sensor RIG-I -0.0183946
IGFBP3 insulin-like growth factor binding protein 3 -0.0183537
RPL23 ribosomal protein L23 -0.0182165