Digoxin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description Digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. (Chemical Entities of Biological Interest Ontology, CHEBI_4551)
External Link http://ctdbase.org/detail.go?type=chem&acc=D004077
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Genes

21 genes/proteins interacting with the chemical Digoxin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
FANCD2 Fanconi anemia, complementation group D2
FANCI Fanconi anemia, complementation group I
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IL6R interleukin 6 receptor
INS insulin
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
RORC RAR-related orphan receptor C
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
VEGFA vascular endothelial growth factor A