Dihydroartemisinin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL3 ribosomal protein L3 0.09993
EEF2 eukaryotic translation elongation factor 2 0.08177
PCBP2 poly(rC) binding protein 2 0.0630549
LDHA lactate dehydrogenase A 0.0597001
MMP12 matrix metallopeptidase 12 0.0593865
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0590665
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0569089
FXR1 fragile X mental retardation, autosomal homolog 1 0.0562033
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0554831
ERRFI1 ERBB receptor feedback inhibitor 1 0.0532642
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0527734
DST dystonin 0.0526349
EHBP1 EH domain binding protein 1 0.0519757
CPNE1 copine I 0.0495978
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0478383
ERBIN erbb2 interacting protein 0.0458798
H1-0 H1.0 linker histone 0.0451178
DDIT3 DNA-damage-inducible transcript 3 0.0420038
MAP1B microtubule-associated protein 1B 0.0419425
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0409125
AARS1 alanyl-tRNA synthetase 1 0.0404763
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0404602
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0395229
HDGF hepatoma-derived growth factor 0.0394167
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0380734
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.038002
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0360219
CANX calnexin 0.0353585
TPM3 tropomyosin 3 0.0353549
AKAP12 A kinase (PRKA) anchor protein 12 0.0353231
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0352715
SET SET nuclear proto-oncogene 0.0345475
CSNK1A1 casein kinase 1, alpha 1 0.0334613
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0331956
BIRC6 baculoviral IAP repeat containing 6 0.0331854
RPL18A ribosomal protein L18a 0.0328458
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0327627
GARS1 glycyl-tRNA synthetase 1 0.0326269
BRD2 bromodomain containing 2 0.0319316
RPL13A ribosomal protein L13a 0.0317533
MCL1 myeloid cell leukemia 1 0.0314482
SRRM2 serine/arginine repetitive matrix 2 0.0305864
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0304907
FBXO11 F-box protein 11 0.0304525
RASAL2 RAS protein activator like 2 0.0303056
MARCHF4 membrane associated ring-CH-type finger 4 0.029285
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0291882
HDLBP high density lipoprotein binding protein 0.0291607
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0291301
MARS1 methionyl-tRNA synthetase 1 0.0291243
ANKRD17 ankyrin repeat domain 17 0.028853
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0286977
RAB10 RAB10, member RAS oncogene family 0.0286474
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0285568
RPS4X ribosomal protein S4, X-linked 0.028472
CARD16 caspase recruitment domain family, member 16 0.0283072
RAB7A RAB7A, member RAS oncogene family 0.0282736
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0282416
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0281183
SLC38A2 solute carrier family 38, member 2 0.0280182
EEF1G eukaryotic translation elongation factor 1 gamma 0.0280156
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0277648
DSCAM Down syndrome cell adhesion molecule 0.0273155
SETD5 SET domain containing 5 0.0266126
HMGA2 high mobility group AT-hook 2 0.0264565
JMJD1C jumonji domain containing 1C 0.0263804
CMIP c-Maf inducing protein 0.0263356
TCP1 t-complex 1 0.0260308
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0260235
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258297
AFF4 AF4/FMR2 family, member 4 0.0256076
ATF6 activating transcription factor 6 0.0255826
ZSWIM6 zinc finger, SWIM-type containing 6 0.0253529
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0251312
DPYD dihydropyrimidine dehydrogenase 0.0247654
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0245808
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0245545
MACF1 microtubule-actin crosslinking factor 1 0.0245284
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0242439
TSC22D2 TSC22 domain family, member 2 0.0241587
CLDN1 claudin 1 0.023839
ZFAND3 zinc finger, AN1-type domain 3 0.0236352
XPOT exportin, tRNA 0.0236179
ADAR adenosine deaminase, RNA-specific 0.0232414
RIMKLB ribosomal modification protein rimK-like family member B 0.0231954
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0231376
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0230535
APP amyloid beta (A4) precursor protein 0.0226736
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0226365
LPP LIM domain containing preferred translocation partner in lipoma 0.0221326
APLP2 amyloid beta (A4) precursor-like protein 2 0.021903
GOLT1A golgi transport 1A 0.0215711
NCAPD2 non-SMC condensin I complex, subunit D2 0.0214914
CALR calreticulin 0.0214768
NABP1 nucleic acid binding protein 1 0.0214471
TTC3 tetratricopeptide repeat domain 3 0.0212659
CARS1 cysteinyl-tRNA synthetase 1 0.0208833
SESN2 sestrin 2 0.0208543
TBL1X transducin (beta)-like 1X-linked 0.0208361
ZCCHC7 zinc finger, CCHC domain containing 7 0.0207696

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199088
TMSB10 thymosin beta 10 -0.154095
VIM vimentin -0.150795
NLGN1 neuroligin 1 -0.080688
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.074477
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0741747
PDE4D phosphodiesterase 4D, cAMP-specific -0.0739914
TPT1 tumor protein, translationally-controlled 1 -0.0594758
MGAT4C MGAT4 family, member C -0.0573572
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0505218
TMEM41B transmembrane protein 41B -0.0474841
ACTG1 actin gamma 1 -0.0454808
RPL35A ribosomal protein L35a -0.0443874
AREG amphiregulin -0.0430735
RPS24 ribosomal protein S24 -0.041213
SMC4 structural maintenance of chromosomes 4 -0.0398684
RPLP1 ribosomal protein, large, P1 -0.0368914
RPL34 ribosomal protein L34 -0.0352703
RPS6 ribosomal protein S6 -0.0350339
RPLP2 ribosomal protein, large, P2 -0.0347499
HMGA1 high mobility group AT-hook 1 -0.0337739
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0335908
CXADR coxsackie virus and adenovirus receptor -0.0335156
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0330999
WWOX WW domain containing oxidoreductase -0.0317142
PCDH7 protocadherin 7 -0.0312316
FTL ferritin, light polypeptide -0.0309367
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0303649
RPS21 ribosomal protein S21 -0.0303043
RPLP0 ribosomal protein, large, P0 -0.0297664
RPL38 ribosomal protein L38 -0.0293019
TUBA1B tubulin, alpha 1b -0.0276116
RPS27A ribosomal protein S27a -0.0269453
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0269254
MIS18BP1 MIS18 binding protein 1 -0.0268499
RRM2 ribonucleotide reductase M2 -0.0267626
RPS8 ribosomal protein S8 -0.0260948
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0259008
RPL26 ribosomal protein L26 -0.025559
RPS2 ribosomal protein S2 -0.0249525
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0248735
ADGRG6 adhesion G protein-coupled receptor G6 -0.0248294
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0246982
RPL9 ribosomal protein L9 -0.0246164
PTMA prothymosin, alpha -0.0243522
MTAP methylthioadenosine phosphorylase -0.024257
IFIH1 interferon induced with helicase C domain 1 -0.0240761
CNRIP1 cannabinoid receptor interacting protein 1 -0.0240285
ZNF217 zinc finger protein 217 -0.0239222
RPS19 ribosomal protein S19 -0.0239066
EDARADD EDAR-associated death domain -0.0235215
TMEM123 transmembrane protein 123 -0.022738
KIAA1328 KIAA1328 -0.0227369
EPHA6 EPH receptor A6 -0.022493
RTN4 reticulon 4 -0.0223555
RACK1 receptor for activated C kinase 1 -0.0221071
RPS15 ribosomal protein S15 -0.0220194
HMGB1 high mobility group box 1 -0.0219275
KIF18B kinesin family member 18B -0.0218837
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0218419
TENM3 teneurin transmembrane protein 3 -0.021714
RPS29 ribosomal protein S29 -0.0216577
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0215171
PDE4B phosphodiesterase 4B, cAMP-specific -0.0214475
RPL23 ribosomal protein L23 -0.0212071
RPL32 ribosomal protein L32 -0.0211917
ATP5F1E ATP synthase F1 subunit epsilon -0.0211868
NHSL1 NHS-like 1 -0.0206705
TPI1 triosephosphate isomerase 1 -0.0204327
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0203869
DIAPH3 diaphanous-related formin 3 -0.0201361
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.020053
IL6ST interleukin 6 signal transducer -0.0194898
PFN1 profilin 1 -0.0193797
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0193389
RPL12 ribosomal protein L12 -0.0192776
RPS16 ribosomal protein S16 -0.0187195
VDAC1 voltage-dependent anion channel 1 -0.0185188
RPS23 ribosomal protein S23 -0.0179041
FGF20 fibroblast growth factor 20 -0.0178723
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0177956
TUBB6 tubulin, beta 6 class V -0.0177299
MARCHF6 membrane associated ring-CH-type finger 6 -0.0175269
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0173289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.017161
TNPO1 transportin 1 -0.0170952
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.01702
TAS2R14 taste receptor, type 2, member 14 -0.0167195
RPL36A ribosomal protein L36a -0.0167193
PCDH9 protocadherin 9 -0.0165266
PRELID2 PRELI domain containing 2 -0.0165194
CCDC88A coiled-coil domain containing 88A -0.0164152
TUBB4B tubulin, beta 4B class IVb -0.016402
CCND1 cyclin D1 -0.0163898
RPL31 ribosomal protein L31 -0.0162842
VCL vinculin -0.0162088
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0161299
GASK1B golgi associated kinase 1B -0.0158854
WDPCP WD repeat containing planar cell polarity effector -0.0157386
GCG glucagon -0.0156955