Dihydroartemisinin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0895266
FAM13A family with sequence similarity 13, member A 0.0541803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0531752
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0464231
RPL3 ribosomal protein L3 0.0462818
OGA O-GlcNAcase 0.0423301
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0415987
FNBP1 formin binding protein 1 0.0388187
HELZ helicase with zinc finger 0.0371586
NAMPT nicotinamide phosphoribosyltransferase 0.035615
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0355021
MYH9 myosin, heavy chain 9, non-muscle 0.0347381
WDR45B WD repeat domain 45B 0.0346038
VEGFA vascular endothelial growth factor A 0.0343107
DDIT4 DNA-damage-inducible transcript 4 0.0332954
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0319769
APP amyloid beta (A4) precursor protein 0.0313301
EEF2 eukaryotic translation elongation factor 2 0.0305778
NDRG1 N-myc downstream regulated 1 0.0289918
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276227
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0274216
LDHA lactate dehydrogenase A 0.0267897
MXI1 MAX interactor 1, dimerization protein 0.0266084
HILPDA hypoxia inducible lipid droplet-associated 0.025051
CSNK1A1 casein kinase 1, alpha 1 0.0249651
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0246762
HMGB2 high mobility group box 2 0.0243431
COPA coatomer protein complex, subunit alpha 0.0234478
KMT2E lysine (K)-specific methyltransferase 2E 0.0230853
MAP1B microtubule-associated protein 1B 0.0229463
DSCAM Down syndrome cell adhesion molecule 0.0228188
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226298
SET SET nuclear proto-oncogene 0.0223757
CANX calnexin 0.0220869
PCBP2 poly(rC) binding protein 2 0.021951
KDM3A lysine (K)-specific demethylase 3A 0.0211668
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0209468
LPIN1 lipin 1 0.0196207
SEPTIN9 septin 9 0.0195085
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0193507
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0193273
NFE2L1 nuclear factor, erythroid 2-like 1 0.0193165
SQSTM1 sequestosome 1 0.0192094
ITPRID2 ITPR interacting domain containing 2 0.0191672
YTHDC1 YTH domain containing 1 0.0190933
MKI67 marker of proliferation Ki-67 0.0188541
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0187623
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0184719
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.018442
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0184057
PKM pyruvate kinase, muscle 0.0180705
SRP54 signal recognition particle 54kDa 0.0179743
CASC3 cancer susceptibility candidate 3 0.0179102
HDGF hepatoma-derived growth factor 0.0177752
MBNL2 muscleblind-like splicing regulator 2 0.0176371
OPTN optineurin 0.0175966
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0175757
CENPF centromere protein F, 350/400kDa 0.0173216
ESYT2 extended synaptotagmin-like protein 2 0.0173045
RPL18A ribosomal protein L18a 0.0172539
UBA6 ubiquitin-like modifier activating enzyme 6 0.0171337
SETD5 SET domain containing 5 0.0171266
NPEPPS aminopeptidase puromycin sensitive 0.0169225
XPO1 exportin 1 0.0168918
SUCO SUN domain containing ossification factor 0.0166248
GOLGA4 golgin A4 0.0163011
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0161591
HOOK2 hook microtubule-tethering protein 2 0.0161461
UBC ubiquitin C 0.0161399
ERRFI1 ERBB receptor feedback inhibitor 1 0.0161184
FLNB filamin B, beta 0.0159816
PDE8A phosphodiesterase 8A 0.0159545
HSPA8 heat shock 70kDa protein 8 0.0158994
FOXO3 forkhead box O3 0.0158047
CD36 CD36 molecule (thrombospondin receptor) 0.0157739
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.015657
SAFB scaffold attachment factor B 0.0155614
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0154629
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0154543
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0154028
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0153783
YME1L1 YME1-like 1 ATPase 0.0153272
GDF15 growth differentiation factor 15 0.0153141
ZFC3H1 zinc finger, C3H1-type containing 0.0152764
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0152693
SEPTIN7 septin 7 0.0152319
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0152135
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.015165
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0149486
SBNO1 strawberry notch homolog 1 (Drosophila) 0.014855
RAD23B RAD23 homolog B (S. cerevisiae) 0.014804
CKAP5 cytoskeleton associated protein 5 0.0147396
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0146094
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0145929
CCNG2 cyclin G2 0.0145351
STAG2 stromal antigen 2 0.014533
TENT5A terminal nucleotidyltransferase 5A 0.0143159
UGCG UDP-glucose ceramide glucosyltransferase 0.0142572
PRPF8 pre-mRNA processing factor 8 0.0140687
TPM3 tropomyosin 3 0.0140578

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.269832
LSAMP limbic system-associated membrane protein -0.216199
NALF1 NALCN channel auxiliary factor 1 -0.139652
NRG1 neuregulin 1 -0.137521
EXT1 exostosin glycosyltransferase 1 -0.111263
PTPRD protein tyrosine phosphatase, receptor type, D -0.104402
FMN1 formin 1 -0.0980164
THSD4 thrombospondin, type I, domain containing 4 -0.0788857
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0735608
VCL vinculin -0.0715777
SYT1 synaptotagmin I -0.0710989
CRH corticotropin releasing hormone -0.0709238
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0694194
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0643857
MEIS2 Meis homeobox 2 -0.0573386
ACTG1 actin gamma 1 -0.0568381
ZNF804A zinc finger protein 804A -0.0555248
RPS24 ribosomal protein S24 -0.0505186
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.050377
RPL35A ribosomal protein L35a -0.0492846
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0484865
TPT1 tumor protein, translationally-controlled 1 -0.0479689
PRKCA protein kinase C, alpha -0.0472906
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0427859
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0421768
KLHL13 kelch-like family member 13 -0.041752
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0409026
CADM2 cell adhesion molecule 2 -0.0407092
MSI2 musashi RNA-binding protein 2 -0.0404971
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0392815
RPS6 ribosomal protein S6 -0.038917
DNAH14 dynein, axonemal, heavy chain 14 -0.0385581
RPL19 ribosomal protein L19 -0.0383466
BCAS3 breast carcinoma amplified sequence 3 -0.0379933
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0379553
TCF12 transcription factor 12 -0.0379538
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0374366
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0362404
PTPRK protein tyrosine phosphatase, receptor type, K -0.036175
BICD1 bicaudal D homolog 1 (Drosophila) -0.0360803
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0356483
EGR1 early growth response 1 -0.0353681
PTPRG protein tyrosine phosphatase, receptor type, G -0.0351483
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0348318
ZBTB20 zinc finger and BTB domain containing 20 -0.0340965
BPTF bromodomain PHD finger transcription factor -0.0339867
IGFBP3 insulin-like growth factor binding protein 3 -0.0338499
CUX1 cut-like homeobox 1 -0.0335307
RIGI RNA sensor RIG-I -0.033053
TMSB10 thymosin beta 10 -0.0326132
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0325812
GREM2 gremlin 2, DAN family BMP antagonist -0.0325065
COL1A1 collagen, type I, alpha 1 -0.032342
MX2 MX dynamin-like GTPase 2 -0.0318993
MAPK10 mitogen-activated protein kinase 10 -0.0303075
RPL34 ribosomal protein L34 -0.0302312
IGFBP5 insulin-like growth factor binding protein 5 -0.0301519
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0296284
TAS2R14 taste receptor, type 2, member 14 -0.0293566
PCDH9 protocadherin 9 -0.0291982
RNF213 ring finger protein 213 -0.0285895
TRIB2 tribbles pseudokinase 2 -0.0283725
COL3A1 collagen, type III, alpha 1 -0.0278837
IER3 immediate early response 3 -0.0278814
RGS5 regulator of G-protein signaling 5 -0.0277309
GPC5 glypican 5 -0.0272969
SOX4 SRY (sex determining region Y)-box 4 -0.0270674
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0269026
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0268608
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0264599
RPL38 ribosomal protein L38 -0.026428
CNTN4 contactin 4 -0.02628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0261435
CDH13 cadherin 13 -0.0260839
SLIT2 slit homolog 2 (Drosophila) -0.0260769
LRP1B low density lipoprotein receptor-related protein 1B -0.0259097
TPST1 tyrosylprotein sulfotransferase 1 -0.0255482
THBS1 thrombospondin 1 -0.0254018
CADM1 cell adhesion molecule 1 -0.0252043
RAD51B RAD51 paralog B -0.0251472
TRIM24 tripartite motif containing 24 -0.0251387
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0251244
COL4A5 collagen, type IV, alpha 5 -0.025101
NPAS2 neuronal PAS domain protein 2 -0.024904
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0246967
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0245458
NREP neuronal regeneration related protein -0.024515
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0241975
ANTXR1 anthrax toxin receptor 1 -0.0241308
KCTD16 potassium channel tetramerization domain containing 16 -0.0238892
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0234982
PRKG1 protein kinase, cGMP-dependent, type I -0.023164
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0230602
ADNP activity-dependent neuroprotector homeobox -0.0229804
IFI16 interferon, gamma-inducible protein 16 -0.0228607
ATXN10 ataxin 10 -0.0227484
FNDC3A fibronectin type III domain containing 3A -0.0225138
DLC1 DLC1 Rho GTPase activating protein -0.0224429
RPS25 ribosomal protein S25 -0.0223508
TENM4 teneurin transmembrane protein 4 -0.0223104