Dihydroartemisinin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.0770299
MACC1 metastasis associated in colon cancer 1 0.073198
CANX calnexin 0.0728197
MYH9 myosin, heavy chain 9, non-muscle 0.0567655
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.056541
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0561566
SPATA13 spermatogenesis associated 13 0.0548442
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0521045
ITGA6 integrin, alpha 6 0.0516108
LDHA lactate dehydrogenase A 0.0464189
STK24 serine/threonine kinase 24 0.043713
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.04326
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0409421
MBNL2 muscleblind-like splicing regulator 2 0.0406053
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0398863
SAMD4A sterile alpha motif domain containing 4A 0.0397707
PADI1 peptidyl arginine deiminase, type I 0.0395325
HDLBP high density lipoprotein binding protein 0.0391876
ERBIN erbb2 interacting protein 0.0375215
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0364717
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0362525
APP amyloid beta (A4) precursor protein 0.0351754
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0351233
EZR ezrin 0.0337776
BCLAF1 BCL2-associated transcription factor 1 0.0332862
RNF149 ring finger protein 149 0.0320976
TRIM2 tripartite motif containing 2 0.0320258
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0318293
ATP11A ATPase, class VI, type 11A 0.0317251
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0306157
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0293292
OCLN occludin 0.0288723
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0288073
NKD1 naked cuticle homolog 1 (Drosophila) 0.028755
RBM39 RNA binding motif protein 39 0.0280669
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277949
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0277143
SREBF2 sterol regulatory element binding transcription factor 2 0.0270144
MSI2 musashi RNA-binding protein 2 0.0265133
EPHB2 EPH receptor B2 0.0262718
CDHR2 cadherin-related family member 2 0.0260722
RUNX1 runt-related transcription factor 1 0.0253077
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0251748
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249054
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0246804
VEGFA vascular endothelial growth factor A 0.0245924
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0240869
N4BP2L2 NEDD4 binding protein 2-like 2 0.0238558
TUFT1 tuftelin 1 0.0237782
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0237566
EPS8 epidermal growth factor receptor pathway substrate 8 0.0235071
CTBP2 C-terminal binding protein 2 0.0234077
BICRAL BICRA like chromatin remodeling complex associated protein 0.0232979
RPL3 ribosomal protein L3 0.0231792
DNM2 dynamin 2 0.0230735
BACE2 beta-site APP-cleaving enzyme 2 0.0226808
FGD5 FYVE, RhoGEF and PH domain containing 5 0.0225654
DSPP dentin sialophosphoprotein 0.0225432
MKI67 marker of proliferation Ki-67 0.0223725
AHNAK AHNAK nucleoprotein 0.0221333
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0220844
ERRFI1 ERBB receptor feedback inhibitor 1 0.0220444
ETNK1 ethanolamine kinase 1 0.0219062
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0219059
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0218217
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0216654
CGN cingulin 0.021609
UBAC2 UBA domain containing 2 0.0215651
KIF16B kinesin family member 16B 0.020913
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0207817
GOLGA2 golgin A2 0.0207124
SLC22A23 solute carrier family 22, member 23 0.0205979
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0204578
ZBTB20 zinc finger and BTB domain containing 20 0.020432
TBCD tubulin folding cofactor D 0.0202532
HDAC4 histone deacetylase 4 0.0200672
RBM26 RNA binding motif protein 26 0.0200145
AFF1 AF4/FMR2 family, member 1 0.0199516
IGF1R insulin-like growth factor 1 receptor 0.0198675
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0198271
SERINC5 serine incorporator 5 0.0197264
MLPH melanophilin 0.0196264
RNF43 ring finger protein 43 0.0195015
PTEN phosphatase and tensin homolog 0.0193129
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0191195
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0190751
ANXA11 annexin A11 0.0189528
CREBRF CREB3 regulatory factor 0.0189408
CEP95 centrosomal protein 95kDa 0.0187691
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0187677
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0187557
UGCG UDP-glucose ceramide glucosyltransferase 0.0186951
ARGLU1 arginine and glutamate rich 1 0.0184226
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0183994
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0183051
ZMYM2 zinc finger, MYM-type 2 0.0182839
CENPF centromere protein F, 350/400kDa 0.0181429
ACBD3 acyl-CoA binding domain containing 3 0.0181352
MXI1 MAX interactor 1, dimerization protein 0.0180814
TPX2 TPX2, microtubule-associated 0.0177413

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.14438
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104005
TPT1 tumor protein, translationally-controlled 1 -0.0975727
LCN2 lipocalin 2 -0.0669349
IFI6 interferon, alpha-inducible protein 6 -0.0659239
GCLC glutamate-cysteine ligase, catalytic subunit -0.0592668
EGR1 early growth response 1 -0.0585602
LYZ lysozyme -0.0543154
STAT1 signal transducer and activator of transcription 1, 91kDa -0.05362
MX2 MX dynamin-like GTPase 2 -0.0533783
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0495252
ACTG1 actin gamma 1 -0.0491023
HLA-B major histocompatibility complex, class I, B -0.0480822
IFI27 interferon, alpha-inducible protein 27 -0.047956
EPSTI1 epithelial stromal interaction 1 (breast) -0.0474597
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.046508
PLSCR2 phospholipid scramblase 2 -0.0465035
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.046277
PTMA prothymosin, alpha -0.0460445
TMSB10 thymosin beta 10 -0.0451103
RPS6 ribosomal protein S6 -0.0450928
RNF213 ring finger protein 213 -0.0441149
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0436604
PKM pyruvate kinase, muscle -0.0434559
RPL23 ribosomal protein L23 -0.0426907
PERP PERP, TP53 apoptosis effector -0.0422965
RIGI RNA sensor RIG-I -0.0418489
SP100 SP100 nuclear antigen -0.0417365
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0410587
FTL ferritin, light polypeptide -0.0402746
RPL35A ribosomal protein L35a -0.0402698
ANXA2 annexin A2 -0.0400453
TM4SF19 transmembrane 4 L six family member 19 -0.0393414
XAF1 XIAP associated factor 1 -0.0380989
CST3 cystatin C -0.0371968
PGK1 phosphoglycerate kinase 1 -0.0369328
RPL34 ribosomal protein L34 -0.0364806
TM4SF1 transmembrane 4 L six family member 1 -0.036434
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0347659
C6ORF132 chromosome 6 open reading frame 132 -0.0345555
RPLP1 ribosomal protein, large, P1 -0.0344056
NPSR1 neuropeptide S receptor 1 -0.0337014
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0335809
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0332363
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0327363
SLC38A1 solute carrier family 38, member 1 -0.0317235
POTEF POTE ankyrin domain family, member F -0.0315519
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0310099
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0309983
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0299574
RPS19 ribosomal protein S19 -0.0296614
MT2A metallothionein 2A -0.0293566
IFITM3 interferon induced transmembrane protein 3 -0.0289419
INTS6 integrator complex subunit 6 -0.0286306
S100A10 S100 calcium binding protein A10 -0.0279343
RAB7A RAB7A, member RAS oncogene family -0.0278448
S100A6 S100 calcium binding protein A6 -0.0276981
AREG amphiregulin -0.0270703
RPS24 ribosomal protein S24 -0.0269875
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.026414
RPL31 ribosomal protein L31 -0.026058
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0259887
IER3 immediate early response 3 -0.0259391
LOC102724023 ES1 protein homolog, mitochondrial -0.0256015
PMP22 peripheral myelin protein 22 -0.0255278
RPS8 ribosomal protein S8 -0.0252131
TXNRD1 thioredoxin reductase 1 -0.0248678
RPLP2 ribosomal protein, large, P2 -0.0245992
ISG15 ISG15 ubiquitin-like modifier -0.0242564
LOC112694756 uncharaterized LOC112694756 -0.024157
FNDC3B fibronectin type III domain containing 3B -0.0239106
RPLP0 ribosomal protein, large, P0 -0.0235938
HKDC1 hexokinase domain containing 1 -0.0234762
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0229378
S100P S100 calcium binding protein P -0.0226777
MX1 MX dynamin-like GTPase 1 -0.0224687
SLC38A2 solute carrier family 38, member 2 -0.0222254
NABP1 nucleic acid binding protein 1 -0.0220913
EFNB2 ephrin-B2 -0.0219035
HLA-C major histocompatibility complex, class I, C -0.0218245
TSHZ2 teashirt zinc finger homeobox 2 -0.0218035
TPI1 triosephosphate isomerase 1 -0.0215694
CTSD cathepsin D -0.0212814
RPS27 ribosomal protein S27 -0.0210781
CATSPERB catsper channel auxiliary subunit beta -0.0210781
ABLIM1 actin binding LIM protein 1 -0.0210391
POF1B premature ovarian failure, 1B -0.0209633
RPS25 ribosomal protein S25 -0.0208916
TFF3 trefoil factor 3 (intestinal) -0.0207714
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0207576
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0207478
S100A11 S100 calcium binding protein A11 -0.0206397
IFIH1 interferon induced with helicase C domain 1 -0.0203642
RPL7L1 ribosomal protein L7-like 1 -0.0202693
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0198852
RPL37A ribosomal protein L37a -0.019372
STS steroid sulfatase (microsomal), isozyme S -0.0193149
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0192253
WARS1 tryptophanyl-tRNA synthetase 1 -0.0191376
ZNFX1 zinc finger, NFX1-type containing 1 -0.0190538