Dihydroartemisinin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.0801801
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0642175
PLEC plectin 0.0586107
MYH9 myosin, heavy chain 9, non-muscle 0.0553064
NAV2 neuron navigator 2 0.0531453
GRB10 growth factor receptor-bound protein 10 0.0468569
TRIO trio Rho guanine nucleotide exchange factor 0.0428206
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0420504
MTSS1 metastasis suppressor 1 0.0414756
RIGI RNA sensor RIG-I 0.0406044
NAMPT nicotinamide phosphoribosyltransferase 0.0403642
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0402928
MCL1 myeloid cell leukemia 1 0.0398548
SMAD3 SMAD family member 3 0.039385
PSD3 pleckstrin and Sec7 domain containing 3 0.0375266
FLNA filamin A, alpha 0.0373
AHNAK AHNAK nucleoprotein 0.0354832
RPL3 ribosomal protein L3 0.0354812
SPAG9 sperm associated antigen 9 0.0348539
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336819
NRIP1 nuclear receptor interacting protein 1 0.0308065
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0303081
INTS6 integrator complex subunit 6 0.0296754
RBM39 RNA binding motif protein 39 0.029431
FNDC3B fibronectin type III domain containing 3B 0.0280019
PLS3 plastin 3 0.0269594
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0265401
DSCAM Down syndrome cell adhesion molecule 0.0264119
TOP1 topoisomerase (DNA) I 0.0260746
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0257955
LAMC2 laminin, gamma 2 0.0253854
H1-0 H1.0 linker histone 0.0248756
PALM2AKAP2 PALM2 and AKAP2 fusion 0.024839
KDM6A lysine (K)-specific demethylase 6A 0.0243582
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0233659
ANKRD11 ankyrin repeat domain 11 0.0233491
LRRC49 leucine rich repeat containing 49 0.0229189
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0223277
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0216335
RICTOR RPTOR independent companion of MTOR, complex 2 0.0212728
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0211364
GARS1 glycyl-tRNA synthetase 1 0.0210837
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0207848
NCOA3 nuclear receptor coactivator 3 0.0204098
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203103
PICALM phosphatidylinositol binding clathrin assembly protein 0.020053
CARS1 cysteinyl-tRNA synthetase 1 0.0199075
ANKRD33B ankyrin repeat domain 33B 0.0198006
OGA O-GlcNAcase 0.0196963
ERRFI1 ERBB receptor feedback inhibitor 1 0.0195759
FNDC3A fibronectin type III domain containing 3A 0.0193706
AFAP1 actin filament associated protein 1 0.0188216
PODXL podocalyxin-like 0.0187414
IARS1 isoleucyl-tRNA synthetase 1 0.0185968
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.018132
VCL vinculin 0.018038
RNF19B ring finger protein 19B 0.0179828
APLP2 amyloid beta (A4) precursor-like protein 2 0.0177735
FNIP1 folliculin interacting protein 1 0.0174879
ZNFX1 zinc finger, NFX1-type containing 1 0.017394
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0172585
MSN moesin 0.0166395
PRELID2 PRELI domain containing 2 0.0163788
KRT17 keratin 17, type I 0.0163116
KIAA1217 KIAA1217 0.0162699
CUL4B cullin 4B 0.0162436
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0160642
WARS1 tryptophanyl-tRNA synthetase 1 0.0160245
TNIP1 TNFAIP3 interacting protein 1 0.0159372
CTNND1 catenin (cadherin-associated protein), delta 1 0.0157371
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0157089
ACTN1 actinin, alpha 1 0.0153812
CLIC4 chloride intracellular channel 4 0.0150898
USP9X ubiquitin specific peptidase 9, X-linked 0.0150098
MYOF myoferlin 0.014902
CEMIP cell migration inducing protein, hyaluronan binding 0.0148873
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0146261
MAST4 microtubule associated serine/threonine kinase family member 4 0.0145472
QKI QKI, KH domain containing, RNA binding 0.0142652
SOD2 superoxide dismutase 2, mitochondrial 0.0141205
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0138629
ESYT2 extended synaptotagmin-like protein 2 0.0136959
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0135922
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0135789
PDLIM5 PDZ and LIM domain 5 0.0135623
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0135079
CPNE1 copine I 0.0133903
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0133163
CAPRIN2 caprin family member 2 0.013246
AARS1 alanyl-tRNA synthetase 1 0.0132154
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0132017
JAK1 Janus kinase 1 0.0129923
SQSTM1 sequestosome 1 0.012897
NPTN neuroplastin 0.0128185
ADAM17 ADAM metallopeptidase domain 17 0.0125929
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0124889
FOXO3 forkhead box O3 0.0124056
COPA coatomer protein complex, subunit alpha 0.0123504
SLC38A1 solute carrier family 38, member 1 0.0123302
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.012245

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.199601
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.087343
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0665895
B2M beta-2-microglobulin -0.0544767
DPYD dihydropyrimidine dehydrogenase -0.0476629
MT2A metallothionein 2A -0.0413589
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.039837
RPS6 ribosomal protein S6 -0.0393405
PTMA prothymosin, alpha -0.038955
IGF2 insulin-like growth factor 2 -0.0377727
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0375568
TPT1 tumor protein, translationally-controlled 1 -0.0367314
S100A10 S100 calcium binding protein A10 -0.0366813
RPS8 ribosomal protein S8 -0.0356972
TMSB10 thymosin beta 10 -0.0356409
ENO1 enolase 1, (alpha) -0.0324416
HSPG2 heparan sulfate proteoglycan 2 -0.0320828
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0318434
CAV1 caveolin 1, caveolae protein, 22kDa -0.0303234
HLA-B major histocompatibility complex, class I, B -0.0302339
RPS21 ribosomal protein S21 -0.0290169
IFITM3 interferon induced transmembrane protein 3 -0.0280522
TMSB4X thymosin beta 4, X-linked -0.0276958
FTL ferritin, light polypeptide -0.026551
IFITM1 interferon induced transmembrane protein 1 -0.0264228
PDE4D phosphodiesterase 4D, cAMP-specific -0.0263759
EMP1 epithelial membrane protein 1 -0.02613
RPS13 ribosomal protein S13 -0.0258795
RPS25 ribosomal protein S25 -0.025691
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0250442
RPLP2 ribosomal protein, large, P2 -0.0248294
S100A11 S100 calcium binding protein A11 -0.0239695
SULF2 sulfatase 2 -0.0236192
TXNIP thioredoxin interacting protein -0.0233837
SULF1 sulfatase 1 -0.0230913
RPL35A ribosomal protein L35a -0.0226625
DOK5 docking protein 5 -0.0225516
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0223775
STC1 stanniocalcin 1 -0.0216469
ZMYND8 zinc finger, MYND-type containing 8 -0.0215716
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0215003
S100A6 S100 calcium binding protein A6 -0.0210756
CDK6 cyclin-dependent kinase 6 -0.0210731
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0210698
FOXP1 forkhead box P1 -0.0208328
PDIA3 protein disulfide isomerase family A, member 3 -0.0207548
PGK1 phosphoglycerate kinase 1 -0.0206654
ANO1 anoctamin 1, calcium activated chloride channel -0.0205154
S100A9 S100 calcium binding protein A9 -0.0202817
POTEF POTE ankyrin domain family, member F -0.0202471
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0199806
RPS19 ribosomal protein S19 -0.0198851
VDAC1 voltage-dependent anion channel 1 -0.0198508
RPS3 ribosomal protein S3 -0.0193973
RPLP1 ribosomal protein, large, P1 -0.0192216
RPS24 ribosomal protein S24 -0.019207
RPS12 ribosomal protein S12 -0.0190561
IFI6 interferon, alpha-inducible protein 6 -0.0188753
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0187731
CD44 CD44 molecule (Indian blood group) -0.0185073
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0176536
RPL36A ribosomal protein L36a -0.0176448
RPL34 ribosomal protein L34 -0.0175302
RPS14 ribosomal protein S14 -0.0174449
RPL37A ribosomal protein L37a -0.0173411
CSTB cystatin B (stefin B) -0.0169285
RPL8 ribosomal protein L8 -0.0164045
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0160725
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0160623
ALCAM activated leukocyte cell adhesion molecule -0.016058
RPL31 ribosomal protein L31 -0.0159051
RPL27A ribosomal protein L27a -0.0158971
ACTG1 actin gamma 1 -0.0158571
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0157734
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0157044
RPL7A ribosomal protein L7a -0.0156924
RPLP0 ribosomal protein, large, P0 -0.0156807
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0155875
IGFBP4 insulin-like growth factor binding protein 4 -0.015586
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0155543
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.015528
PALLD palladin, cytoskeletal associated protein -0.0153449
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0153254
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0152127
S100A2 S100 calcium binding protein A2 -0.0151589
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0150766
RPL37 ribosomal protein L37 -0.015019
CAV2 caveolin 2 -0.0149169
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0148082
RPL5 ribosomal protein L5 -0.0147769
LMNA lamin A/C -0.014488
ACTN4 actinin, alpha 4 -0.0144226
IFI27 interferon, alpha-inducible protein 27 -0.0143576
MTDH metadherin -0.014232
TSC22D1 TSC22 domain family, member 1 -0.0141274
MAML2 mastermind-like 2 (Drosophila) -0.0141244
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0139927
RPS23 ribosomal protein S23 -0.0139905
GNAS GNAS complex locus -0.0139868
HMGA1 high mobility group AT-hook 1 -0.0139179