Dihydroartemisinin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.243388
VIM vimentin 0.162665
TXNRD1 thioredoxin reductase 1 0.156889
RAI1 retinoic acid induced 1 0.134277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.116016
ERRFI1 ERBB receptor feedback inhibitor 1 0.110931
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0867765
CANX calnexin 0.0843599
TM4SF1 transmembrane 4 L six family member 1 0.0840014
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0802185
LDHA lactate dehydrogenase A 0.0764697
EZR ezrin 0.0750428
EEF2 eukaryotic translation elongation factor 2 0.0729538
MACF1 microtubule-actin crosslinking factor 1 0.0693923
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0680823
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0663236
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0660323
APP amyloid beta (A4) precursor protein 0.0626411
BCAR3 breast cancer anti-estrogen resistance 3 0.0615588
AHNAK AHNAK nucleoprotein 0.0607385
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0588897
CENPF centromere protein F, 350/400kDa 0.0580111
KTN1 kinectin 1 (kinesin receptor) 0.0573973
SLC38A2 solute carrier family 38, member 2 0.0572008
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0543184
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0521931
RPL3 ribosomal protein L3 0.0451117
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0443663
EREG epiregulin 0.0443055
MKI67 marker of proliferation Ki-67 0.0443046
EMP1 epithelial membrane protein 1 0.0436722
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0428063
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0424097
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0420937
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0420468
ARHGAP5 Rho GTPase activating protein 5 0.0416872
TMEM41B transmembrane protein 41B 0.0415205
GCLM glutamate-cysteine ligase, modifier subunit 0.0412899
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0410402
PLK2 polo-like kinase 2 0.04035
TRIP12 thyroid hormone receptor interactor 12 0.0403483
CEP170 centrosomal protein 170kDa 0.0395975
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0387652
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0385317
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0382539
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0378577
HDLBP high density lipoprotein binding protein 0.037689
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0366047
WWTR1 WW domain containing transcription regulator 1 0.0351163
USP34 ubiquitin specific peptidase 34 0.0350792
SET SET nuclear proto-oncogene 0.0349691
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.034178
YBX3 Y box binding protein 3 0.0340031
MT1X metallothionein 1X 0.0339936
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0339329
CSDE1 cold shock domain containing E1, RNA-binding 0.0335707
KMT2E lysine (K)-specific methyltransferase 2E 0.0335547
SEC24A SEC24 family member A 0.0332062
TTC3 tetratricopeptide repeat domain 3 0.0330131
LMAN1 lectin, mannose-binding, 1 0.0326548
DPYSL2 dihydropyrimidinase-like 2 0.0323702
RGS4 regulator of G-protein signaling 4 0.0320261
ADAM17 ADAM metallopeptidase domain 17 0.0317303
RTN4 reticulon 4 0.0315437
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0312571
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312102
PGK1 phosphoglycerate kinase 1 0.0311456
ERBIN erbb2 interacting protein 0.0311121
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0309025
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.030749
ANTXR2 anthrax toxin receptor 2 0.0303704
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0300897
CSNK1A1 casein kinase 1, alpha 1 0.0300351
TOP1 topoisomerase (DNA) I 0.0291334
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0289905
XPO1 exportin 1 0.0284424
TPM4 tropomyosin 4 0.0283914
ANGPTL4 angiopoietin-like 4 0.0283775
SDCCAG8 serologically defined colon cancer antigen 8 0.0280108
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0279785
NCAPD2 non-SMC condensin I complex, subunit D2 0.0276977
MBNL2 muscleblind-like splicing regulator 2 0.0276503
POM121 POM121 transmembrane nucleoporin 0.027532
WDR26 WD repeat domain 26 0.0275245
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0275069
ARHGAP29 Rho GTPase activating protein 29 0.0274947
RUNX1 runt-related transcription factor 1 0.0273401
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0272379
PCBP2 poly(rC) binding protein 2 0.027201
ADGRG6 adhesion G protein-coupled receptor G6 0.0266908
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.026455
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0263355
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0263063
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.025923
GIGYF2 GRB10 interacting GYF protein 2 0.0257453
FXR1 fragile X mental retardation, autosomal homolog 1 0.0255175
DSCAM Down syndrome cell adhesion molecule 0.0255029
ANKRD17 ankyrin repeat domain 17 0.025366
CAPN2 calpain 2, (m/II) large subunit 0.0252641

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.206992
TMSB10 thymosin beta 10 -0.128966
HLA-B major histocompatibility complex, class I, B -0.110018
RPL35A ribosomal protein L35a -0.0893872
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0817826
CADM2 cell adhesion molecule 2 -0.0751171
TPT1 tumor protein, translationally-controlled 1 -0.0701724
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0686693
PTMA prothymosin, alpha -0.0631624
SP100 SP100 nuclear antigen -0.062297
LRRC49 leucine rich repeat containing 49 -0.0607815
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0583533
RAD51B RAD51 paralog B -0.0575233
PRELID2 PRELI domain containing 2 -0.0567898
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0566881
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0559672
WARS1 tryptophanyl-tRNA synthetase 1 -0.0522462
RPS8 ribosomal protein S8 -0.0519465
RPL26 ribosomal protein L26 -0.0515755
RIGI RNA sensor RIG-I -0.0508206
RPS19 ribosomal protein S19 -0.0499588
RPL31 ribosomal protein L31 -0.0490758
RPL12 ribosomal protein L12 -0.04841
RPL37A ribosomal protein L37a -0.0474771
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0474571
RNF213 ring finger protein 213 -0.0470802
TNS3 tensin 3 -0.0469682
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0469516
RPL38 ribosomal protein L38 -0.0461396
FTL ferritin, light polypeptide -0.0460894
RPLP1 ribosomal protein, large, P1 -0.0454396
RPL36 ribosomal protein L36 -0.0453071
NEK10 NIMA-related kinase 10 -0.0432607
DPH6 diphthamine biosynthesis 6 -0.0420687
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0418013
RPS12 ribosomal protein S12 -0.0415057
IFIH1 interferon induced with helicase C domain 1 -0.0406028
RPLP2 ribosomal protein, large, P2 -0.0396554
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0396008
DST dystonin -0.0395616
RPS6 ribosomal protein S6 -0.0394594
RPL23 ribosomal protein L23 -0.0387045
RPL28 ribosomal protein L28 -0.0378441
RPL36A ribosomal protein L36a -0.0377472
RPL34 ribosomal protein L34 -0.0376657
PLSCR1 phospholipid scramblase 1 -0.0374122
RPS24 ribosomal protein S24 -0.0372095
RPS29 ribosomal protein S29 -0.0343991
RPL37 ribosomal protein L37 -0.0342804
RPL35 ribosomal protein L35 -0.0314457
B2M beta-2-microglobulin -0.0311895
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0305961
RPS10 ribosomal protein S10 -0.0304412
EFNA5 ephrin-A5 -0.0301692
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0299962
INTS6 integrator complex subunit 6 -0.0299936
RAB7A RAB7A, member RAS oncogene family -0.0287625
IFITM1 interferon induced transmembrane protein 1 -0.0283321
RPS23 ribosomal protein S23 -0.0283099
RPS27 ribosomal protein S27 -0.0280358
ISG15 ISG15 ubiquitin-like modifier -0.0278577
RPL19 ribosomal protein L19 -0.0278254
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0276929
ANKRD11 ankyrin repeat domain 11 -0.0274736
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0274559
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0271594
IFI6 interferon, alpha-inducible protein 6 -0.0269904
VCL vinculin -0.0269687
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0269444
PRKCE protein kinase C, epsilon -0.0269112
COL5A2 collagen, type V, alpha 2 -0.0269032
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0266633
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0260751
CSMD3 CUB and Sushi multiple domains 3 -0.0258177
HDAC9 histone deacetylase 9 -0.0252549
RPS27A ribosomal protein S27a -0.0251116
DPYD dihydropyrimidine dehydrogenase -0.024651
PMP22 peripheral myelin protein 22 -0.0245512
RFC3 replication factor C (activator 1) 3, 38kDa -0.0241984
WSB1 WD repeat and SOCS box containing 1 -0.0240929
DNAH14 dynein, axonemal, heavy chain 14 -0.0237103
H1-0 H1.0 linker histone -0.0230342
RPL11 ribosomal protein L11 -0.022789
FUS FUS RNA binding protein -0.0224781
SDK1 sidekick cell adhesion molecule 1 -0.0223829
RPS17 ribosomal protein S17 -0.0223827
DENND1A DENN/MADD domain containing 1A -0.0220375
RPS20 ribosomal protein S20 -0.0219827
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0219282
PDE10A phosphodiesterase 10A -0.0218506
DNER delta/notch-like EGF repeat containing -0.0217869
SLC38A1 solute carrier family 38, member 1 -0.0215517
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0213965
RPL9 ribosomal protein L9 -0.0213771
HMGB1 high mobility group box 1 -0.021283
RPS28 ribosomal protein S28 -0.0212806
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0211518
RPS14 ribosomal protein S14 -0.0210705
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0208815
FTH1 ferritin, heavy polypeptide 1 -0.020844