Dihydroartemisinin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0764241
RPL3 ribosomal protein L3 0.0748956
APP amyloid beta (A4) precursor protein 0.0478137
ERRFI1 ERBB receptor feedback inhibitor 1 0.047602
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0448849
DSCAM Down syndrome cell adhesion molecule 0.0427412
EEF2 eukaryotic translation elongation factor 2 0.0396686
TPM3 tropomyosin 3 0.0393253
TXNRD1 thioredoxin reductase 1 0.0385019
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0383236
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0370462
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369105
RPL13A ribosomal protein L13a 0.034937
CANX calnexin 0.0337867
LDHA lactate dehydrogenase A 0.0335219
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0335106
RBM39 RNA binding motif protein 39 0.0331145
MCL1 myeloid cell leukemia 1 0.0330672
ANKRD11 ankyrin repeat domain 11 0.0326842
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0315951
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0304314
MYH9 myosin, heavy chain 9, non-muscle 0.0303744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0302406
RPL4 ribosomal protein L4 0.0301649
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0300531
RPL18A ribosomal protein L18a 0.0299061
HSPA8 heat shock 70kDa protein 8 0.029381
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0283684
FGB fibrinogen beta chain 0.0282401
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.02814
SAMD4A sterile alpha motif domain containing 4A 0.0278283
APLP2 amyloid beta (A4) precursor-like protein 2 0.0276421
ERBIN erbb2 interacting protein 0.0271671
HDGF hepatoma-derived growth factor 0.0256591
ZFAND3 zinc finger, AN1-type domain 3 0.0253091
CXCL8 chemokine (C-X-C motif) ligand 8 0.0252542
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.024858
WDR43 WD repeat domain 43 0.0242006
FLNA filamin A, alpha 0.0234262
ACTN1 actinin, alpha 1 0.0215599
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0214379
AKAP12 A kinase (PRKA) anchor protein 12 0.0213651
AARS1 alanyl-tRNA synthetase 1 0.0212671
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0205539
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0197323
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0196564
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.019122
EEF1G eukaryotic translation elongation factor 1 gamma 0.0185169
BRD2 bromodomain containing 2 0.0183279
MACF1 microtubule-actin crosslinking factor 1 0.0181196
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0178199
RBM8A RNA binding motif protein 8A 0.0175709
HDLBP high density lipoprotein binding protein 0.0174902
PTK2 protein tyrosine kinase 2 0.0169074
CSDE1 cold shock domain containing E1, RNA-binding 0.0166337
PCBP2 poly(rC) binding protein 2 0.0162257
FAM168A family with sequence similarity 168, member A 0.016213
SET SET nuclear proto-oncogene 0.0160308
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0156658
FXR1 fragile X mental retardation, autosomal homolog 1 0.0155623
FLNB filamin B, beta 0.0155217
THBS1 thrombospondin 1 0.0155069
YTHDC1 YTH domain containing 1 0.0154448
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.015269
NUP58 nucleoporin 58 0.0152118
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0150625
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0148675
YME1L1 YME1-like 1 ATPase 0.0148632
ADAR adenosine deaminase, RNA-specific 0.0146456
SRRM2 serine/arginine repetitive matrix 2 0.0145487
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0144344
EIF3B eukaryotic translation initiation factor 3, subunit B 0.01441
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0142571
TARS1 threonyl-tRNA synthetase 1 0.0141886
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0141822
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0141224
HYOU1 hypoxia up-regulated 1 0.0141084
CFLAR CASP8 and FADD-like apoptosis regulator 0.0140362
KDM3A lysine (K)-specific demethylase 3A 0.0139571
COPA coatomer protein complex, subunit alpha 0.0138014
CPNE1 copine I 0.0137878
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0137005
SRSF5 serine/arginine-rich splicing factor 5 0.0136354
ADAM17 ADAM metallopeptidase domain 17 0.013504
ILF3 interleukin enhancer binding factor 3, 90kDa 0.013324
TCP1 t-complex 1 0.0130659
SMOC1 SPARC related modular calcium binding 1 0.0130333
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0130153
EIF4H eukaryotic translation initiation factor 4H 0.0129858
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0128871
MKI67 marker of proliferation Ki-67 0.012877
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0128402
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0128335
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0128225
RPTOR regulatory associated protein of MTOR, complex 1 0.0127421
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0127389
MARS1 methionyl-tRNA synthetase 1 0.0127186
PLEC plectin 0.0126395
YBX3 Y box binding protein 3 0.0125992
NUMA1 nuclear mitotic apparatus protein 1 0.01243

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.239333
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204223
TMSB10 thymosin beta 10 -0.118732
FTL ferritin, light polypeptide -0.103514
VIM vimentin -0.0808331
IGF2 insulin-like growth factor 2 -0.047187
PDE4D phosphodiesterase 4D, cAMP-specific -0.0395253
S100A6 S100 calcium binding protein A6 -0.0342902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326156
PFN1 profilin 1 -0.0325139
ACTG1 actin gamma 1 -0.0322986
TFPI2 tissue factor pathway inhibitor 2 -0.0295013
PM20D1 peptidase M20 domain containing 1 -0.0277008
C15ORF48 chromosome 15 open reading frame 48 -0.0254914
RPLP1 ribosomal protein, large, P1 -0.024941
RPL35A ribosomal protein L35a -0.0246743
RPS29 ribosomal protein S29 -0.0233189
RPS19 ribosomal protein S19 -0.0216618
RPL31 ribosomal protein L31 -0.0214474
STC1 stanniocalcin 1 -0.0206883
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0204697
RPS8 ribosomal protein S8 -0.0204224
HMGA1 high mobility group AT-hook 1 -0.0199993
S100A10 S100 calcium binding protein A10 -0.0195174
IER3 immediate early response 3 -0.0190282
TM4SF1 transmembrane 4 L six family member 1 -0.0189276
RPS23 ribosomal protein S23 -0.0185889
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0177954
RPS25 ribosomal protein S25 -0.0173776
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0173645
S100A11 S100 calcium binding protein A11 -0.0172044
RPS21 ribosomal protein S21 -0.0171495
EGR1 early growth response 1 -0.017036
TPT1 tumor protein, translationally-controlled 1 -0.0164771
RPL36 ribosomal protein L36 -0.0163886
POTEF POTE ankyrin domain family, member F -0.0159522
RPL28 ribosomal protein L28 -0.0156648
RPS15 ribosomal protein S15 -0.0150656
VDAC1 voltage-dependent anion channel 1 -0.015047
RPS5 ribosomal protein S5 -0.0150093
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0144404
RPS16 ribosomal protein S16 -0.0143294
RPLP0 ribosomal protein, large, P0 -0.0142791
ATP5F1E ATP synthase F1 subunit epsilon -0.014137
RPS6 ribosomal protein S6 -0.0138995
PKM pyruvate kinase, muscle -0.0137892
GRAMD1B GRAM domain containing 1B -0.013758
B2M beta-2-microglobulin -0.013756
RPLP2 ribosomal protein, large, P2 -0.0137363
RPS24 ribosomal protein S24 -0.0135486
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0135333
S100A9 S100 calcium binding protein A9 -0.0131978
TPI1 triosephosphate isomerase 1 -0.0131462
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0130213
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0129694
NNMT nicotinamide N-methyltransferase -0.0124995
HLA-B major histocompatibility complex, class I, B -0.0121723
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0121275
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.011976
RPL36A ribosomal protein L36a -0.0117036
RPL34 ribosomal protein L34 -0.0114836
PYGL phosphorylase, glycogen, liver -0.0113848
MAML3 mastermind-like 3 (Drosophila) -0.0112424
IFITM3 interferon induced transmembrane protein 3 -0.0112237
RACK1 receptor for activated C kinase 1 -0.0109133
LOC102724023 ES1 protein homolog, mitochondrial -0.0108031
RPS27A ribosomal protein S27a -0.0107193
RPS13 ribosomal protein S13 -0.0107016
SERF2 small EDRK-rich factor 2 -0.0106379
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.010602
IGFBP4 insulin-like growth factor binding protein 4 -0.0104574
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0103912
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0102384
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0102296
PRDX1 peroxiredoxin 1 -0.0101868
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00994377
RPL15 ribosomal protein L15 -0.00977513
EFNA5 ephrin-A5 -0.00965022
RPL37A ribosomal protein L37a -0.00964847
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00935553
RPS27 ribosomal protein S27 -0.00935331
RPL9 ribosomal protein L9 -0.00929436
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0092335
FGG fibrinogen gamma chain -0.00911043
BICC1 BicC family RNA binding protein 1 -0.00899213
RPL30 ribosomal protein L30 -0.00883335
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00881178
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0087815
TUBA1B tubulin, alpha 1b -0.00874269
HSPB1 heat shock 27kDa protein 1 -0.00859634
CNRIP1 cannabinoid receptor interacting protein 1 -0.00857519
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.00856783
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.00846654
RPL12 ribosomal protein L12 -0.00842513
SOX4 SRY (sex determining region Y)-box 4 -0.00831105
ASTN2 astrotactin 2 -0.0082882
RPL32 ribosomal protein L32 -0.0081953
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00807748
WWOX WW domain containing oxidoreductase -0.00805125
CYB5R3 cytochrome b5 reductase 3 -0.00796241