Dihydroartemisinin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

68 genes differentially expressed following the Dihydroartemisinin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.221849
LDHA lactate dehydrogenase A 0.161514
EEF2 eukaryotic translation elongation factor 2 0.125542
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.1046
CANX calnexin 0.0989571
PTK2 protein tyrosine kinase 2 0.0981742
ANXA2 annexin A2 0.0940889
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0929346
RTN4 reticulon 4 0.0880923
NUP58 nucleoporin 58 0.0788107
MCL1 myeloid cell leukemia 1 0.077737
UBC ubiquitin C 0.0756398
RPS3 ribosomal protein S3 0.0749729
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0744054
BIRC6 baculoviral IAP repeat containing 6 0.07012
RPL11 ribosomal protein L11 0.0687147
RPL23 ribosomal protein L23 0.0683603
PGK1 phosphoglycerate kinase 1 0.0650691
ACTN4 actinin, alpha 4 0.0606838
SETD5 SET domain containing 5 0.0479186
TPT1 tumor protein, translationally-controlled 1 0.0435874
PTMA prothymosin, alpha 0.0429294
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0404481
RORA RAR-related orphan receptor A 0.0365285
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0319828
ANKRD17 ankyrin repeat domain 17 0.0306991
VCL vinculin 0.0268533
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0191829
VIM vimentin 0.0190505
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0182382
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.013082
FN1 fibronectin 1 0.0114143
ZBTB20 zinc finger and BTB domain containing 20 0.010865
JMJD1C jumonji domain containing 1C 0.00982816
TRIO trio Rho guanine nucleotide exchange factor 0.00893467
OGA O-GlcNAcase 0.0077483
CDH13 cadherin 13 0.00728553
FNDC3A fibronectin type III domain containing 3A 0.00564845
PDE10A phosphodiesterase 10A 0.0033402
IGFBP3 insulin-like growth factor binding protein 3 0.00273015
GPC6 glypican 6 1.01E-4
DST dystonin 4.98063E-5

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.205703
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.186848
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.168254
PDE4D phosphodiesterase 4D, cAMP-specific -0.16606
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.107203
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.106656
EFNA5 ephrin-A5 -0.0777331
PRKCA protein kinase C, alpha -0.0738871
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0649988
FNDC3B fibronectin type III domain containing 3B -0.061126
EGFR epidermal growth factor receptor -0.0610189
MAML2 mastermind-like 2 (Drosophila) -0.0592196
PSD3 pleckstrin and Sec7 domain containing 3 -0.0537062
SMYD3 SET and MYND domain containing 3 -0.0447266
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0443982
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.043054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0416942
PTPRM protein tyrosine phosphatase, receptor type, M -0.0394933
NKD1 naked cuticle homolog 1 (Drosophila) -0.0391936
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0374477
ASPH aspartate beta-hydroxylase -0.0340567
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.024945
ATXN1 ataxin 1 -0.017689
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0174916
NAMPT nicotinamide phosphoribosyltransferase -0.0132125
MYO1E myosin IE -0.0123211