Dihydroartemisinin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0884915
RPL3 ribosomal protein L3 0.0647785
FLNB filamin B, beta 0.0608258
ADAM10 ADAM metallopeptidase domain 10 0.0607703
TXNRD1 thioredoxin reductase 1 0.0497112
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.048428
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0453852
ZBTB20 zinc finger and BTB domain containing 20 0.0439493
DSCAM Down syndrome cell adhesion molecule 0.04176
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0417258
SMYD3 SET and MYND domain containing 3 0.0413255
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0396158
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0392964
RBM39 RNA binding motif protein 39 0.0381937
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0372763
COG5 component of oligomeric golgi complex 5 0.0353919
TMSB4X thymosin beta 4, X-linked 0.0349425
TBC1D5 TBC1 domain family, member 5 0.0346732
HDLBP high density lipoprotein binding protein 0.0346363
LOXL3 lysyl oxidase-like 3 0.0342369
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0338631
PTPRG protein tyrosine phosphatase, receptor type, G 0.0338315
ANK2 ankyrin 2, neuronal 0.0334885
ZFAND3 zinc finger, AN1-type domain 3 0.033107
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0323967
GSK3B glycogen synthase kinase 3 beta 0.0323742
VCL vinculin 0.0322689
EML4 echinoderm microtubule associated protein like 4 0.0313399
MBD5 methyl-CpG binding domain protein 5 0.0308552
AHNAK AHNAK nucleoprotein 0.0308459
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.030671
TRERF1 transcriptional regulating factor 1 0.0302693
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0302305
ANKRD17 ankyrin repeat domain 17 0.0302222
GOLGA4 golgin A4 0.0302171
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0301697
ZNF292 zinc finger protein 292 0.030103
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0300853
SAMD4A sterile alpha motif domain containing 4A 0.0298806
LDHA lactate dehydrogenase A 0.0297544
PYGB phosphorylase, glycogen; brain 0.0297475
ANKRD36 ankyrin repeat domain 36 0.0296419
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0293602
RHBDD1 rhomboid domain containing 1 0.029319
PNISR PNN-interacting serine/arginine-rich protein 0.029316
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0289091
ATM ATM serine/threonine kinase 0.0286462
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0284579
OSMR oncostatin M receptor 0.0283766
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0277751
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0272645
METTL15 methyltransferase like 15 0.027248
PRPF38B pre-mRNA processing factor 38B 0.0266522
CCNL1 cyclin L1 0.0265933
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0261569
PGK1 phosphoglycerate kinase 1 0.0259442
ADAM9 ADAM metallopeptidase domain 9 0.025863
PTEN phosphatase and tensin homolog 0.025811
ARL15 ADP-ribosylation factor-like 15 0.0254823
ABHD12 abhydrolase domain containing 12 0.025317
ZCCHC7 zinc finger, CCHC domain containing 7 0.0251112
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0248903
SPIDR scaffolding protein involved in DNA repair 0.0246827
RTN4 reticulon 4 0.0246522
ACACA acetyl-CoA carboxylase alpha 0.0242129
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0241716
YTHDC1 YTH domain containing 1 0.0239808
RNF145 ring finger protein 145 0.0233959
NF1 neurofibromin 1 0.0224811
TTC3 tetratricopeptide repeat domain 3 0.022418
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0224088
KDM3A lysine (K)-specific demethylase 3A 0.0221898
NCEH1 neutral cholesterol ester hydrolase 1 0.0220271
GOLGA2 golgin A2 0.0217401
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0215005
TBC1D22A TBC1 domain family, member 22A 0.0214614
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0214444
NEK7 NIMA-related kinase 7 0.0213679
CSDE1 cold shock domain containing E1, RNA-binding 0.0213376
WDR43 WD repeat domain 43 0.0213297
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0212616
BCAS3 breast carcinoma amplified sequence 3 0.0212174
NCKAP1 NCK-associated protein 1 0.0212006
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.021058
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0210575
APP amyloid beta (A4) precursor protein 0.0210415
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0207285
PTBP2 polypyrimidine tract binding protein 2 0.020688
RB1CC1 RB1-inducible coiled-coil 1 0.0206751
TCF12 transcription factor 12 0.0206327
ELOVL5 ELOVL fatty acid elongase 5 0.0206202
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0203568
CAMTA1 calmodulin binding transcription activator 1 0.0202639
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0202065
DSTN destrin (actin depolymerizing factor) 0.0200898
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0200639
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0200528
AHI1 Abelson helper integration site 1 0.0199675
TMEM39A transmembrane protein 39A 0.0198851
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.0198163

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149466
PTMA prothymosin, alpha -0.141563
PDE4B phosphodiesterase 4B, cAMP-specific -0.132497
RPS6 ribosomal protein S6 -0.105502
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.103076
RPS8 ribosomal protein S8 -0.100418
BMP10 bone morphogenetic protein 10 -0.0875336
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0837566
TPT1 tumor protein, translationally-controlled 1 -0.0657732
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0645237
MKI67 marker of proliferation Ki-67 -0.0635263
RPL35A ribosomal protein L35a -0.0627123
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0605937
ANXA1 annexin A1 -0.058012
PDE4D phosphodiesterase 4D, cAMP-specific -0.0569702
RPLP1 ribosomal protein, large, P1 -0.0535344
ACTG1 actin gamma 1 -0.0525677
RPL12 ribosomal protein L12 -0.052313
RPL34 ribosomal protein L34 -0.0516636
DIAPH3 diaphanous-related formin 3 -0.0507225
DLG1 discs, large homolog 1 (Drosophila) -0.0500779
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0482747
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0457369
CENPF centromere protein F, 350/400kDa -0.0444673
RPL31 ribosomal protein L31 -0.0412187
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0410373
RPS23 ribosomal protein S23 -0.0403294
SOX6 SRY (sex determining region Y)-box 6 -0.0397473
RPL9 ribosomal protein L9 -0.0382291
SMC4 structural maintenance of chromosomes 4 -0.036557
RPS19 ribosomal protein S19 -0.0359686
LOC102724023 ES1 protein homolog, mitochondrial -0.0357195
RPS12 ribosomal protein S12 -0.03488
RPL37A ribosomal protein L37a -0.0344355
RACK1 receptor for activated C kinase 1 -0.0337337
HSPB1 heat shock 27kDa protein 1 -0.0332828
TUBA1B tubulin, alpha 1b -0.0327508
RPL26 ribosomal protein L26 -0.0317254
RPL36 ribosomal protein L36 -0.0313943
ENO1 enolase 1, (alpha) -0.0313438
RPS13 ribosomal protein S13 -0.0310414
TMSB10 thymosin beta 10 -0.030515
ANLN anillin, actin binding protein -0.0301144
RPL19 ribosomal protein L19 -0.0295625
TUBB4B tubulin, beta 4B class IVb -0.0289618
POTEF POTE ankyrin domain family, member F -0.0287595
RPS25 ribosomal protein S25 -0.0286293
RPL7A ribosomal protein L7a -0.028442
RPLP2 ribosomal protein, large, P2 -0.0283863
TPX2 TPX2, microtubule-associated -0.0278668
KPNB1 karyopherin (importin) beta 1 -0.0274195
HJURP Holliday junction recognition protein -0.027095
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0269861
HMGB1 high mobility group box 1 -0.0265293
RPLP0 ribosomal protein, large, P0 -0.0264525
RFC3 replication factor C (activator 1) 3, 38kDa -0.0263356
RPS24 ribosomal protein S24 -0.0261982
RPS14 ribosomal protein S14 -0.0260257
RPL11 ribosomal protein L11 -0.0255977
RPS2 ribosomal protein S2 -0.0255411
CCND1 cyclin D1 -0.0254642
RPS11 ribosomal protein S11 -0.0253653
FER1L6 fer-1-like family member 6 -0.0253194
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0250447
RPS21 ribosomal protein S21 -0.0248732
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0248657
RPL7 ribosomal protein L7 -0.0240608
RPL23 ribosomal protein L23 -0.0240237
RPL28 ribosomal protein L28 -0.0238927
RRM2 ribonucleotide reductase M2 -0.0235164
EMP3 epithelial membrane protein 3 -0.0234293
TUBB tubulin, beta class I -0.0233439
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0231652
RPL8 ribosomal protein L8 -0.0230981
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0228247
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0228176
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0227887
CUX1 cut-like homeobox 1 -0.0227481
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0226866
NAP1L1 nucleosome assembly protein 1-like 1 -0.0226719
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0223939
RPS20 ribosomal protein S20 -0.0222422
TPI1 triosephosphate isomerase 1 -0.0221705
RAN RAN, member RAS oncogene family -0.0219285
RPS16 ribosomal protein S16 -0.0216603
RPS17 ribosomal protein S17 -0.0216588
UNC13A unc-13 homolog A (C. elegans) -0.0215447
RPS27 ribosomal protein S27 -0.0214745
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0210249
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0208451
GLI3 GLI family zinc finger 3 -0.0207342
S100A10 S100 calcium binding protein A10 -0.0203016
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0201207
RPS27A ribosomal protein S27a -0.0201024
RPS5 ribosomal protein S5 -0.0198886
S100A9 S100 calcium binding protein A9 -0.0197289
CREB5 cAMP responsive element binding protein 5 -0.0196722
RPS29 ribosomal protein S29 -0.019604
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0195308
ENO2 enolase 2 (gamma, neuronal) -0.0193841