Dihydroartemisinin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.161391
DSCAM Down syndrome cell adhesion molecule 0.131056
IGFBP3 insulin-like growth factor binding protein 3 0.123197
MYH9 myosin, heavy chain 9, non-muscle 0.116454
RBM39 RNA binding motif protein 39 0.108429
EEF2 eukaryotic translation elongation factor 2 0.0969477
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0826628
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0715311
RPL3 ribosomal protein L3 0.0698474
MACF1 microtubule-actin crosslinking factor 1 0.0663576
CEP250 centrosomal protein 250kDa 0.0653681
CPNE1 copine I 0.0646012
CANX calnexin 0.0607544
APLP2 amyloid beta (A4) precursor-like protein 2 0.058883
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0585342
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0579888
WAC WW domain containing adaptor with coiled-coil 0.0576322
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0560289
TPX2 TPX2, microtubule-associated 0.0559661
GOLGA4 golgin A4 0.0534755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0527619
SET SET nuclear proto-oncogene 0.0519599
FLNA filamin A, alpha 0.0516957
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0515476
NAP1L1 nucleosome assembly protein 1-like 1 0.0502617
FMNL2 formin-like 2 0.0493133
MCL1 myeloid cell leukemia 1 0.048515
AFF4 AF4/FMR2 family, member 4 0.0476361
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0462992
HDLBP high density lipoprotein binding protein 0.0449515
GLS2 glutaminase 2 (liver, mitochondrial) 0.0443942
EIF1 eukaryotic translation initiation factor 1 0.0442734
BASP1 brain abundant, membrane attached signal protein 1 0.0434087
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0432587
ITCH itchy E3 ubiquitin protein ligase 0.04249
NAV2 neuron navigator 2 0.0423441
GIGYF2 GRB10 interacting GYF protein 2 0.041581
RPL4 ribosomal protein L4 0.0413456
PTMA prothymosin, alpha 0.0408486
RPL13A ribosomal protein L13a 0.0408367
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0400496
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0397626
FNIP1 folliculin interacting protein 1 0.0387032
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0385006
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0383464
PEAK1 pseudopodium-enriched atypical kinase 1 0.0382304
PCBP2 poly(rC) binding protein 2 0.0381288
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0380269
SETD5 SET domain containing 5 0.0379987
SPAG9 sperm associated antigen 9 0.037756
XRN2 5'-3' exoribonuclease 2 0.0376203
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0376074
ECT2 epithelial cell transforming 2 0.0374214
MSN moesin 0.0372506
SQSTM1 sequestosome 1 0.0371438
RPL18A ribosomal protein L18a 0.0369724
CAPRIN2 caprin family member 2 0.0367898
MATR3 matrin 3 0.0366234
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0360191
ANKRD11 ankyrin repeat domain 11 0.0357761
BIRC3 baculoviral IAP repeat containing 3 0.0353182
TPM4 tropomyosin 4 0.0352768
SOD2 superoxide dismutase 2, mitochondrial 0.0348966
SRRM2 serine/arginine repetitive matrix 2 0.0344315
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0340057
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.033418
ACTN1 actinin, alpha 1 0.0334045
PDE4D phosphodiesterase 4D, cAMP-specific 0.0332106
FLNB filamin B, beta 0.033125
TRIO trio Rho guanine nucleotide exchange factor 0.03299
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0329288
ANKRD36C ankyrin repeat domain 36C 0.0329216
MTREX Mtr4 exosome RNA helicase 0.0328982
RPL23 ribosomal protein L23 0.0326808
SDC4 syndecan 4 0.0326107
NAMPT nicotinamide phosphoribosyltransferase 0.0325392
ERRFI1 ERBB receptor feedback inhibitor 1 0.0323884
MRE11 MRE11 homolog, double strand break repair nuclease 0.032244
MPRIP myosin phosphatase Rho interacting protein 0.0322306
CENPF centromere protein F, 350/400kDa 0.0317254
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0315971
GOLGA3 golgin A3 0.0314351
RBM27 RNA binding motif protein 27 0.0311811
SATB2 SATB homeobox 2 0.0311444
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0309806
OSMR oncostatin M receptor 0.0309534
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0307997
SRP54 signal recognition particle 54kDa 0.0306395
AARS1 alanyl-tRNA synthetase 1 0.0302336
FXR1 fragile X mental retardation, autosomal homolog 1 0.0300569
PICALM phosphatidylinositol binding clathrin assembly protein 0.0291133
NPTN neuroplastin 0.0291039
TCP1 t-complex 1 0.0289843
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0289656
TOP2B topoisomerase (DNA) II beta 180kDa 0.0288729
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0287881
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.028655
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0284903
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0282705
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0281799

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.272258
TMSB10 thymosin beta 10 -0.0849639
TPT1 tumor protein, translationally-controlled 1 -0.0719212
POTEF POTE ankyrin domain family, member F -0.0561929
MT2A metallothionein 2A -0.0471145
DPYD dihydropyrimidine dehydrogenase -0.0394225
PFN1 profilin 1 -0.0392968
RORA RAR-related orphan receptor A -0.0392738
HMGA2 high mobility group AT-hook 2 -0.0385897
ZBTB20 zinc finger and BTB domain containing 20 -0.0358091
FNDC3B fibronectin type III domain containing 3B -0.0351584
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0334831
TM4SF1 transmembrane 4 L six family member 1 -0.0329283
RTN4 reticulon 4 -0.0324091
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0320955
TPI1 triosephosphate isomerase 1 -0.0316593
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0316332
ANGPTL4 angiopoietin-like 4 -0.0310146
ZFHX3 zinc finger homeobox 3 -0.0303477
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0302489
ZMYND8 zinc finger, MYND-type containing 8 -0.0296871
SVIL supervillin -0.029223
HLA-B major histocompatibility complex, class I, B -0.0290017
NALCN sodium leak channel, non selective -0.0286512
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0275218
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0271669
CDK6 cyclin-dependent kinase 6 -0.0271615
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0271611
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0270217
HMGA1 high mobility group AT-hook 1 -0.0262894
TMEM123 transmembrane protein 123 -0.0257041
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0256741
S100A6 S100 calcium binding protein A6 -0.025639
NPEPPS aminopeptidase puromycin sensitive -0.025589
RAI14 retinoic acid induced 14 -0.0254937
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0254298
EXOC4 exocyst complex component 4 -0.0253903
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0253249
PDS5A PDS5 cohesin associated factor A -0.0251481
JMJD1C jumonji domain containing 1C -0.0249372
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0248349
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0246727
TUBA1B tubulin, alpha 1b -0.024658
SNX14 sorting nexin 14 -0.0243231
ZNF83 zinc finger protein 83 -0.0242093
FBXL17 F-box and leucine-rich repeat protein 17 -0.0241631
NF1 neurofibromin 1 -0.0238942
RPS24 ribosomal protein S24 -0.0238175
ACTG1 actin gamma 1 -0.0236193
RPS19 ribosomal protein S19 -0.0235945
ZC3H6 zinc finger CCCH-type containing 6 -0.0235224
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0232707
FMN1 formin 1 -0.0232555
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.023102
B2M beta-2-microglobulin -0.0230358
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0228771
FTL ferritin, light polypeptide -0.0227812
S100A9 S100 calcium binding protein A9 -0.0227271
ATG12 autophagy related 12 -0.0226322
EFNA5 ephrin-A5 -0.022609
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0225914
DEK DEK proto-oncogene -0.0225461
CDK19 cyclin-dependent kinase 19 -0.0224208
IER3 immediate early response 3 -0.0219798
NLK nemo-like kinase -0.0216788
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0216033
FNDC3A fibronectin type III domain containing 3A -0.0214567
LOC112694756 uncharaterized LOC112694756 -0.021407
RPL35A ribosomal protein L35a -0.0212066
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0209607
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0208808
PRKCI protein kinase C, iota -0.020693
IFIH1 interferon induced with helicase C domain 1 -0.020596
APOLD1 apolipoprotein L domain containing 1 -0.020491
PRH1 proline-rich protein HaeIII subfamily 1 -0.0203161
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0203158
SCAMP1 secretory carrier membrane protein 1 -0.0202837
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0202202
AK1 adenylate kinase 1 -0.020192
GLCCI1 glucocorticoid induced 1 -0.0201723
RPL38 ribosomal protein L38 -0.0200389
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0199286
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0198858
SASH1 SAM and SH3 domain containing 1 -0.0197295
RPS13 ribosomal protein S13 -0.0196005
PERP PERP, TP53 apoptosis effector -0.0195718
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0194615
DENND4C DENN/MADD domain containing 4C -0.0192022
GPC6 glypican 6 -0.019108
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0190794
PCNX2 pecanex 2 -0.0190181
MBD5 methyl-CpG binding domain protein 5 -0.0188159
ENO1 enolase 1, (alpha) -0.018724
NDUFA4 NDUFA4, mitochondrial complex associated -0.0187065
HSPB1 heat shock 27kDa protein 1 -0.0186334
FMR1 fragile X mental retardation 1 -0.0185839
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0185838
ISG15 ISG15 ubiquitin-like modifier -0.0185136
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.0184857
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0184553