Dihydroartemisinin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dihydroartemisinin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dihydroartemisinin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0826294
STC2 stanniocalcin 2 0.0756187
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0714094
APLP2 amyloid beta (A4) precursor-like protein 2 0.0647606
NDRG1 N-myc downstream regulated 1 0.0540621
CXCL8 chemokine (C-X-C motif) ligand 8 0.0503487
CANX calnexin 0.050044
RPL3 ribosomal protein L3 0.0463054
HDGF hepatoma-derived growth factor 0.0448077
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0441116
MCL1 myeloid cell leukemia 1 0.0417493
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0415808
TRIO trio Rho guanine nucleotide exchange factor 0.0391167
PCBP2 poly(rC) binding protein 2 0.0386858
SRRM2 serine/arginine repetitive matrix 2 0.0378568
CD109 CD109 molecule 0.0375681
MYH9 myosin, heavy chain 9, non-muscle 0.0369002
PLIN2 perilipin 2 0.0363582
LDHA lactate dehydrogenase A 0.0342016
TPM3 tropomyosin 3 0.0321061
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0319569
SOD2 superoxide dismutase 2, mitochondrial 0.0315471
MRPS6 mitochondrial ribosomal protein S6 0.0315069
ESYT2 extended synaptotagmin-like protein 2 0.0291222
SFTPA2 surfactant protein A2 0.0286577
FLNB filamin B, beta 0.028653
DENND5B DENN/MADD domain containing 5B 0.0283513
APP amyloid beta (A4) precursor protein 0.0276933
FLNA filamin A, alpha 0.027487
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0271756
YTHDC1 YTH domain containing 1 0.0267256
NKTR natural killer cell triggering receptor 0.0266435
COPA coatomer protein complex, subunit alpha 0.0260016
TBC1D22A TBC1 domain family, member 22A 0.0258149
BRD2 bromodomain containing 2 0.0256734
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0252682
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0252038
ENO2 enolase 2 (gamma, neuronal) 0.0250237
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0249054
CALU calumenin 0.024852
GOLGA4 golgin A4 0.0247033
RAB6A RAB6A, member RAS oncogene family 0.0246845
FBN1 fibrillin 1 0.024576
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.024557
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0243691
ZCCHC7 zinc finger, CCHC domain containing 7 0.0242406
CTBP2 C-terminal binding protein 2 0.0239543
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0237008
DDIT4 DNA-damage-inducible transcript 4 0.0235483
SEC23A Sec23 homolog A (S. cerevisiae) 0.0234762
NFE2L1 nuclear factor, erythroid 2-like 1 0.0234579
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0231129
TXNIP thioredoxin interacting protein 0.0230238
ZMIZ1 zinc finger, MIZ-type containing 1 0.022793
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0227125
DOCK5 dedicator of cytokinesis 5 0.0224408
DSCAM Down syndrome cell adhesion molecule 0.0224176
RAB18 RAB18, member RAS oncogene family 0.0223273
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0222847
WAC WW domain containing adaptor with coiled-coil 0.0220203
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0218471
HDLBP high density lipoprotein binding protein 0.0213885
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0212861
NUMA1 nuclear mitotic apparatus protein 1 0.020685
SND1 staphylococcal nuclease and tudor domain containing 1 0.020245
FAM13A family with sequence similarity 13, member A 0.0202264
ADAM17 ADAM metallopeptidase domain 17 0.0202166
HIPK2 homeodomain interacting protein kinase 2 0.0200585
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0200182
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0199595
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0199113
GOLGA3 golgin A3 0.0197793
TMF1 TATA element modulatory factor 1 0.0197446
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197029
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0196635
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0194806
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.019288
TTC3 tetratricopeptide repeat domain 3 0.0191991
FNIP1 folliculin interacting protein 1 0.0191042
FTH1 ferritin, heavy polypeptide 1 0.0190915
SOS1 son of sevenless homolog 1 (Drosophila) 0.0189621
EEF2 eukaryotic translation elongation factor 2 0.0188913
PLEC plectin 0.0187931
CALR calreticulin 0.0187005
AARS1 alanyl-tRNA synthetase 1 0.0186785
WARS1 tryptophanyl-tRNA synthetase 1 0.0183214
OPTN optineurin 0.0182979
ZC3H12C zinc finger CCCH-type containing 12C 0.0180352
ZNF638 zinc finger protein 638 0.0180014
ACBD3 acyl-CoA binding domain containing 3 0.0179045
TENT2 terminal nucleotidyltransferase 2 0.0178277
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.017817
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0177817
ZNF148 zinc finger protein 148 0.0177451
TMEM165 transmembrane protein 165 0.0177416
SMOX spermine oxidase 0.0177411
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0176121
GIGYF2 GRB10 interacting GYF protein 2 0.0175339
SECISBP2L SECIS binding protein 2-like 0.0172366
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0172299

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.377476
FN1 fibronectin 1 -0.243506
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.162814
ASPH aspartate beta-hydroxylase -0.0892949
NRG1 neuregulin 1 -0.0760654
TMSB10 thymosin beta 10 -0.070005
VCL vinculin -0.0665568
GLIS3 GLIS family zinc finger 3 -0.0649683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0552258
MT2A metallothionein 2A -0.0541505
EXT1 exostosin glycosyltransferase 1 -0.0539377
NTN4 netrin 4 -0.0527121
SQSTM1 sequestosome 1 -0.0488764
EFNA5 ephrin-A5 -0.04855
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0480392
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.047755
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0469374
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0456126
HLA-B major histocompatibility complex, class I, B -0.0447317
TMEM156 transmembrane protein 156 -0.044193
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0439546
IFI16 interferon, gamma-inducible protein 16 -0.0438953
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0422683
S100A6 S100 calcium binding protein A6 -0.0405483
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0386004
TPT1 tumor protein, translationally-controlled 1 -0.0383776
PTMA prothymosin, alpha -0.0373267
RPLP1 ribosomal protein, large, P1 -0.0365751
RRBP1 ribosome binding protein 1 -0.035027
IER3 immediate early response 3 -0.0347716
RPL26 ribosomal protein L26 -0.0342844
FOXP1 forkhead box P1 -0.0338678
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0338388
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0337139
PALLD palladin, cytoskeletal associated protein -0.033439
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.033082
RPS6 ribosomal protein S6 -0.0317058
CD44 CD44 molecule (Indian blood group) -0.0309599
OSMR oncostatin M receptor -0.0306071
ELL2 elongation factor, RNA polymerase II, 2 -0.0305113
RIGI RNA sensor RIG-I -0.0302054
ANKRD28 ankyrin repeat domain 28 -0.0293282
WSB1 WD repeat and SOCS box containing 1 -0.0293242
NRP1 neuropilin 1 -0.0290307
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0280675
SYT1 synaptotagmin I -0.027767
ETV1 ets variant 1 -0.0273336
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0272238
FNDC3A fibronectin type III domain containing 3A -0.0272125
RPS24 ribosomal protein S24 -0.0269203
TPI1 triosephosphate isomerase 1 -0.0266117
S100A10 S100 calcium binding protein A10 -0.0262529
FTL ferritin, light polypeptide -0.026137
WWTR1 WW domain containing transcription regulator 1 -0.0257303
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0253318
SP100 SP100 nuclear antigen -0.0250014
NCOA7 nuclear receptor coactivator 7 -0.0249407
RPL12 ribosomal protein L12 -0.0247974
HMGA2 high mobility group AT-hook 2 -0.0245072
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0244592
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0242613
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0240897
ITGA1 integrin, alpha 1 -0.0240023
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0239116
MYO10 myosin X -0.0237287
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0235226
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0234549
RPL34 ribosomal protein L34 -0.0233444
RPL35A ribosomal protein L35a -0.023267
PDE4D phosphodiesterase 4D, cAMP-specific -0.0232037
ARF1 ADP-ribosylation factor 1 -0.0230838
LOC112694756 uncharaterized LOC112694756 -0.0229551
MBD5 methyl-CpG binding domain protein 5 -0.0229198
TMSB4X thymosin beta 4, X-linked -0.0229119
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0228343
RNF213 ring finger protein 213 -0.0228339
RPS28 ribosomal protein S28 -0.0225261
RACK1 receptor for activated C kinase 1 -0.0221743
SOX4 SRY (sex determining region Y)-box 4 -0.0221011
RAB31 RAB31, member RAS oncogene family -0.0218615
VCAN versican -0.0215808
SVIL supervillin -0.0215078
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0214223
RPL30 ribosomal protein L30 -0.0212194
RPS21 ribosomal protein S21 -0.0211116
NXN nucleoredoxin -0.0210317
LTBP1 latent transforming growth factor beta binding protein 1 -0.0208958
CAPN2 calpain 2, (m/II) large subunit -0.0206648
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0205606
RPS19 ribosomal protein S19 -0.0202701
IFI27 interferon, alpha-inducible protein 27 -0.020268
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0201611
AOPEP aminopeptidase O (putative) -0.0199694
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.019903
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0197656
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0195809
RPL38 ribosomal protein L38 -0.0195747
RPL31 ribosomal protein L31 -0.0192432
KLHL5 kelch-like family member 5 -0.0190518
LOC102724023 ES1 protein homolog, mitochondrial -0.0189551