Diltiazem Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension. (Chemical Entities of Biological Interest Ontology, CHEBI_101278)
External Link http://ctdbase.org/detail.go?type=chem&acc=D004110
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Genes

21 genes/proteins interacting with the chemical Diltiazem from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADRB1 adrenoceptor beta 1
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CAT catalase
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
IL12A interleukin 12A
IL12B interleukin 12B
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK2 potassium channel, two pore domain subfamily K, member 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
STAR steroidogenic acute regulatory protein