Dimethyl fumarate_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.187826
ARHGAP26 Rho GTPase activating protein 26 0.0936763
FNDC3B fibronectin type III domain containing 3B 0.0851633
PDE10A phosphodiesterase 10A 0.0781328
SMAD3 SMAD family member 3 0.0667791
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0602358
GRB10 growth factor receptor-bound protein 10 0.0593842
NRIP1 nuclear receptor interacting protein 1 0.056746
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0502172
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0462857
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0448315
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0437284
AUTS2 autism susceptibility candidate 2 0.0416992
MSN moesin 0.0416633
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0401306
TGM2 transglutaminase 2 0.0390424
EPAS1 endothelial PAS domain protein 1 0.0374431
MCL1 myeloid cell leukemia 1 0.0369868
ITGB5 integrin, beta 5 0.0358251
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0357646
RNF213 ring finger protein 213 0.0353613
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324849
DGKD diacylglycerol kinase, delta 130kDa 0.0323709
CMIP c-Maf inducing protein 0.0301849
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0301196
DOCK5 dedicator of cytokinesis 5 0.0296517
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0285621
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0284103
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0281058
PDE8A phosphodiesterase 8A 0.0278535
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0275267
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0263054
ANGPTL4 angiopoietin-like 4 0.0262394
THSD4 thrombospondin, type I, domain containing 4 0.0260138
OSMR oncostatin M receptor 0.0260086
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0256416
RTN4 reticulon 4 0.025548
KYNU kynureninase 0.0252566
EGFR epidermal growth factor receptor 0.0244014
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0238394
MAML3 mastermind-like 3 (Drosophila) 0.0236663
CCNL1 cyclin L1 0.0232125
GPC6 glypican 6 0.0229101
GPRIN3 GPRIN family member 3 0.0227825
LAMA5 laminin, alpha 5 0.0224151
NPC1 Niemann-Pick disease, type C1 0.0222012
MYO1B myosin IB 0.0221211
EFNA5 ephrin-A5 0.0218677
WWOX WW domain containing oxidoreductase 0.0217869
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0217136
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0217101
PRKCE protein kinase C, epsilon 0.0215399
VCL vinculin 0.0212334
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0212155
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.021049
RIGI RNA sensor RIG-I 0.0204998
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0204137
PSD3 pleckstrin and Sec7 domain containing 3 0.020335
DSCAM Down syndrome cell adhesion molecule 0.0203245
RAD51B RAD51 paralog B 0.020294
MYH9 myosin, heavy chain 9, non-muscle 0.0201469
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0195454
RIN2 Ras and Rab interactor 2 0.0195403
FLNB filamin B, beta 0.0195364
SHB Src homology 2 domain containing adaptor protein B 0.0193454
DUSP5 dual specificity phosphatase 5 0.0192443
C1D C1D nuclear receptor corepressor 0.0190808
PRELID2 PRELI domain containing 2 0.0187871
SP3 Sp3 transcription factor 0.01871
ASPH aspartate beta-hydroxylase 0.018015
PDE4B phosphodiesterase 4B, cAMP-specific 0.0179659
TNS1 tensin 1 0.0178355
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0178011
BCL2L1 BCL2-like 1 0.0176396
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0174839
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0174176
AXL AXL receptor tyrosine kinase 0.0170535
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0168306
HSPA8 heat shock 70kDa protein 8 0.0167231
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0165536
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0163452
FAM13A family with sequence similarity 13, member A 0.0162536
TRIM25 tripartite motif containing 25 0.0160272
ANKRD11 ankyrin repeat domain 11 0.0159692
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0154059
STC1 stanniocalcin 1 0.015261
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0152548
ANO6 anoctamin 6 0.0152009
SH3KBP1 SH3-domain kinase binding protein 1 0.0151997
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0151139
TBC1D5 TBC1 domain family, member 5 0.0150018
SLC38A2 solute carrier family 38, member 2 0.0149232
CEMIP cell migration inducing protein, hyaluronan binding 0.0148194
KDM7A lysine (K)-specific demethylase 7A 0.0146686
GRAMD1B GRAM domain containing 1B 0.0143952
ADAM17 ADAM metallopeptidase domain 17 0.0143177
EGR1 early growth response 1 0.0140104
SMYD3 SET and MYND domain containing 3 0.0139962
RPL3 ribosomal protein L3 0.0139848
ECPAS Ecm29 proteasome adaptor and scaffold 0.0139802

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.202809
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196951
TMSB10 thymosin beta 10 -0.159734
ACTG1 actin gamma 1 -0.140109
VIM vimentin -0.133162
RPLP1 ribosomal protein, large, P1 -0.0986587
RPS6 ribosomal protein S6 -0.0976592
PTMA prothymosin, alpha -0.0936342
RPS19 ribosomal protein S19 -0.0906344
TPT1 tumor protein, translationally-controlled 1 -0.0832316
EIF1 eukaryotic translation initiation factor 1 -0.0743907
RPS16 ribosomal protein S16 -0.0707868
NAP1L1 nucleosome assembly protein 1-like 1 -0.070274
RPS24 ribosomal protein S24 -0.0689425
S100A6 S100 calcium binding protein A6 -0.0683187
S100A10 S100 calcium binding protein A10 -0.0660649
ANXA2 annexin A2 -0.0654987
RPL23 ribosomal protein L23 -0.061575
RPL26 ribosomal protein L26 -0.0611809
RPS27A ribosomal protein S27a -0.0608303
KRT81 keratin 81, type II -0.060155
RPL12 ribosomal protein L12 -0.0595129
TKT transketolase -0.0582816
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0577934
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0527894
RPLP0 ribosomal protein, large, P0 -0.0522564
RPS8 ribosomal protein S8 -0.0515146
KDM3A lysine (K)-specific demethylase 3A -0.0505263
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0462753
RPL19 ribosomal protein L19 -0.045436
RPS5 ribosomal protein S5 -0.0449146
KRT7 keratin 7, type II -0.0433983
RPL8 ribosomal protein L8 -0.0423196
RPS3 ribosomal protein S3 -0.0422677
UBC ubiquitin C -0.0419312
BHLHE40 basic helix-loop-helix family, member e40 -0.0416135
RACK1 receptor for activated C kinase 1 -0.0402197
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0399225
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0395773
USP3 ubiquitin specific peptidase 3 -0.0394338
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0384921
RPL35A ribosomal protein L35a -0.0377049
CANX calnexin -0.0374301
RPL31 ribosomal protein L31 -0.0366809
RPS13 ribosomal protein S13 -0.0366067
KCTD9 potassium channel tetramerization domain containing 9 -0.0360129
RPL37A ribosomal protein L37a -0.0359428
PKM pyruvate kinase, muscle -0.0358423
RPLP2 ribosomal protein, large, P2 -0.0348224
RPL18 ribosomal protein L18 -0.0342245
RPL32 ribosomal protein L32 -0.0336783
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0334637
RPL34 ribosomal protein L34 -0.0328904
SLC38A1 solute carrier family 38, member 1 -0.0323623
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0321811
RPS17 ribosomal protein S17 -0.0315919
RPS21 ribosomal protein S21 -0.0314369
RPL28 ribosomal protein L28 -0.0312132
RPL36A ribosomal protein L36a -0.0311711
AHNAK AHNAK nucleoprotein -0.0307894
VDAC1 voltage-dependent anion channel 1 -0.0307837
MORF4L2 mortality factor 4 like 2 -0.0305163
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.03041
RPS23 ribosomal protein S23 -0.0303793
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0302527
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0299299
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0298553
RPL11 ribosomal protein L11 -0.0298015
RPS11 ribosomal protein S11 -0.029553
FBL fibrillarin -0.0295263
AKR1C2 aldo-keto reductase family 1, member C2 -0.0289779
RAB1A RAB1A, member RAS oncogene family -0.0287174
C15ORF48 chromosome 15 open reading frame 48 -0.0286392
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0285894
KRT18 keratin 18, type I -0.0282005
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0281075
MT2A metallothionein 2A -0.0280058
KPNB1 karyopherin (importin) beta 1 -0.0279848
RPS12 ribosomal protein S12 -0.0279313
RPL7A ribosomal protein L7a -0.0277543
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0273792
RSL1D1 ribosomal L1 domain containing 1 -0.0273039
RPL27A ribosomal protein L27a -0.0264669
RPS14 ribosomal protein S14 -0.0264351
PFN1 profilin 1 -0.0261373
IARS1 isoleucyl-tRNA synthetase 1 -0.0259342
RPL7 ribosomal protein L7 -0.025747
TPM4 tropomyosin 4 -0.0257211
PGK1 phosphoglycerate kinase 1 -0.0252559
RPS27 ribosomal protein S27 -0.0250041
EIF4A1 eukaryotic translation initiation factor 4A1 -0.024959
RPL38 ribosomal protein L38 -0.024783
FBXL2 F-box and leucine-rich repeat protein 2 -0.0247764
NOP58 NOP58 ribonucleoprotein -0.0247305
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0245534
LDHB lactate dehydrogenase B -0.024523
HMGA1 high mobility group AT-hook 1 -0.0243187
RPL5 ribosomal protein L5 -0.0242508
TMSB4X thymosin beta 4, X-linked -0.0242133
SPAG9 sperm associated antigen 9 -0.0241481