Dimethyl fumarate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.249148
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.12691
PRELID2 PRELI domain containing 2 0.0614517
OGA O-GlcNAcase 0.05486
ZNF292 zinc finger protein 292 0.0523874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0517851
SRRM2 serine/arginine repetitive matrix 2 0.0510676
VEGFA vascular endothelial growth factor A 0.0508006
EEF2 eukaryotic translation elongation factor 2 0.0479924
MT2A metallothionein 2A 0.0437274
PDGFC platelet derived growth factor C 0.0429414
CDK19 cyclin-dependent kinase 19 0.042179
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0419327
TRA2A transformer 2 alpha homolog (Drosophila) 0.0410822
RPL11 ribosomal protein L11 0.0405824
HMGB2 high mobility group box 2 0.0402633
RNF130 ring finger protein 130 0.0390021
GSE1 Gse1 coiled-coil protein 0.0389339
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0379228
LOC112694756 uncharaterized LOC112694756 0.0362637
MED13L mediator complex subunit 13-like 0.0354161
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0352502
RPS2 ribosomal protein S2 0.035091
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.034827
KDM6A lysine (K)-specific demethylase 6A 0.0345759
PRRC2A proline-rich coiled-coil 2A 0.0341703
FER fer (fps/fes related) tyrosine kinase 0.0333071
RPL3 ribosomal protein L3 0.0332106
ENO1 enolase 1, (alpha) 0.0331558
MKI67 marker of proliferation Ki-67 0.0329475
ZNF638 zinc finger protein 638 0.0325616
NBAS neuroblastoma amplified sequence 0.0324171
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0323939
FGFR2 fibroblast growth factor receptor 2 0.031753
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0310933
ZFAND3 zinc finger, AN1-type domain 3 0.0309763
RAD23B RAD23 homolog B (S. cerevisiae) 0.0307522
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0307416
ZMYM2 zinc finger, MYM-type 2 0.0306687
CABIN1 calcineurin binding protein 1 0.0306604
NEK7 NIMA-related kinase 7 0.0304503
PABPN1 poly(A) binding protein, nuclear 1 0.0301441
PDE4B phosphodiesterase 4B, cAMP-specific 0.0299135
YEATS2 YEATS domain containing 2 0.029563
SRSF11 serine/arginine-rich splicing factor 11 0.0295112
RBM39 RNA binding motif protein 39 0.0290514
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0275669
TM9SF2 transmembrane 9 superfamily member 2 0.0269338
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.026924
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0265741
PHF20 PHD finger protein 20 0.0265492
FBXL7 F-box and leucine-rich repeat protein 7 0.0264779
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0262059
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.0262024
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0261586
MIS18BP1 MIS18 binding protein 1 0.0260993
DIPK2A divergent protein kinase domain 2A 0.0258161
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0257992
GPR107 G protein-coupled receptor 107 0.0256082
MATR3 matrin 3 0.0253142
KMT2C lysine (K)-specific methyltransferase 2C 0.025266
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0251949
ITGAV integrin, alpha V 0.0251229
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0248866
RPL12 ribosomal protein L12 0.0247653
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.024708
RPL27 ribosomal protein L27 0.0245719
SUCO SUN domain containing ossification factor 0.0244733
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0244572
MBD5 methyl-CpG binding domain protein 5 0.0243829
RBM25 RNA binding motif protein 25 0.024269
EYA1 EYA transcriptional coactivator and phosphatase 1 0.024194
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0240141
PER1 period circadian clock 1 0.0240092
B2M beta-2-microglobulin 0.0236873
BHLHE40 basic helix-loop-helix family, member e40 0.0236748
RNF150 ring finger protein 150 0.0235899
CENPE centromere protein E, 312kDa 0.0234743
ZNF608 zinc finger protein 608 0.0234352
TCERG1 transcription elongation regulator 1 0.0233651
METAP2 methionyl aminopeptidase 2 0.0231166
TPD52 tumor protein D52 0.0230657
PDIA3 protein disulfide isomerase family A, member 3 0.022808
PCDH7 protocadherin 7 0.0227513
NDFIP1 Nedd4 family interacting protein 1 0.0225907
USP3 ubiquitin specific peptidase 3 0.0225383
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0225037
GAS2L3 growth arrest-specific 2 like 3 0.0223305
NUDCD3 NudC domain containing 3 0.0218468
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.021802
APP amyloid beta (A4) precursor protein 0.0217823
RPSA ribosomal protein SA 0.0217686
HOXA3 homeobox A3 0.0217491
RPL13A ribosomal protein L13a 0.0215386
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0215246
KIF23 kinesin family member 23 0.0214819
RPL28 ribosomal protein L28 0.0214797
SNRPC small nuclear ribonucleoprotein polypeptide C 0.021469
EEF1G eukaryotic translation elongation factor 1 gamma 0.0212714
PNISR PNN-interacting serine/arginine-rich protein 0.0211104

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.15424
VIM vimentin -0.121372
PRKG1 protein kinase, cGMP-dependent, type I -0.106858
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0936902
HMGA2 high mobility group AT-hook 2 -0.0921997
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0872372
SOX4 SRY (sex determining region Y)-box 4 -0.0741185
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0739294
PEG10 paternally expressed 10 -0.0735858
TSHZ2 teashirt zinc finger homeobox 2 -0.0695612
MGP matrix Gla protein -0.0644042
TPM4 tropomyosin 4 -0.0638158
TPK1 thiamin pyrophosphokinase 1 -0.0580651
IER3 immediate early response 3 -0.0569165
TRIO trio Rho guanine nucleotide exchange factor -0.0567085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0555024
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0553352
CUX1 cut-like homeobox 1 -0.0553321
CTBP2 C-terminal binding protein 2 -0.0541119
VCL vinculin -0.0514456
CANX calnexin -0.0512448
GMDS GDP-mannose 4,6-dehydratase -0.0475095
RANBP17 RAN binding protein 17 -0.0466368
SENP6 SUMO1/sentrin specific peptidase 6 -0.042906
RPS27A ribosomal protein S27a -0.0427452
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0422275
CDK13 cyclin-dependent kinase 13 -0.0419724
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0407149
AKAP12 A kinase (PRKA) anchor protein 12 -0.0401342
RPL34 ribosomal protein L34 -0.0401033
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0396692
MSRB3 methionine sulfoxide reductase B3 -0.0383099
JMJD1C jumonji domain containing 1C -0.0379575
FAF1 Fas (TNFRSF6) associated factor 1 -0.0375002
NIPBL Nipped-B homolog (Drosophila) -0.0367282
AHNAK AHNAK nucleoprotein -0.0364498
DEK DEK proto-oncogene -0.0356521
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0355668
NBEA neurobeachin -0.0351438
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0341371
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0339012
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0335364
RSU1 Ras suppressor protein 1 -0.032955
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0329113
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0327823
ZNF106 zinc finger protein 106 -0.0327574
MAP1B microtubule-associated protein 1B -0.0327004
HMGA1 high mobility group AT-hook 1 -0.0321747
TTC3 tetratricopeptide repeat domain 3 -0.0321156
RPS24 ribosomal protein S24 -0.0319814
SHISA3 shisa family member 3 -0.0312805
KANK1 KN motif and ankyrin repeat domains 1 -0.0311112
FBXO11 F-box protein 11 -0.0310514
BPTF bromodomain PHD finger transcription factor -0.0309581
RACK1 receptor for activated C kinase 1 -0.0308734
RAB7A RAB7A, member RAS oncogene family -0.0304662
CDK6 cyclin-dependent kinase 6 -0.0304596
PTMA prothymosin, alpha -0.0302271
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.029848
DLG1 discs, large homolog 1 (Drosophila) -0.0290842
MEOX2 mesenchyme homeobox 2 -0.028527
SLC38A2 solute carrier family 38, member 2 -0.0285069
RPS3 ribosomal protein S3 -0.0284788
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0280904
ADIPOR2 adiponectin receptor 2 -0.0280175
MYOF myoferlin -0.0279341
WBP11 WW domain binding protein 11 -0.0275834
TCF12 transcription factor 12 -0.0272975
GPATCH8 G patch domain containing 8 -0.0271977
TPR translocated promoter region, nuclear basket protein -0.0271367
FNDC3B fibronectin type III domain containing 3B -0.0269199
MAML3 mastermind-like 3 (Drosophila) -0.0268978
MED13 mediator complex subunit 13 -0.0267307
MACF1 microtubule-actin crosslinking factor 1 -0.026726
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0266845
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0264989
IARS1 isoleucyl-tRNA synthetase 1 -0.0264097
DOCK1 dedicator of cytokinesis 1 -0.0263887
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0263413
INTS6 integrator complex subunit 6 -0.026152
TJP1 tight junction protein 1 -0.0258748
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0258009
CREBBP CREB binding protein -0.0257229
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0255677
TMEM41B transmembrane protein 41B -0.0255536
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0254269
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0250317
LMO7 LIM domain 7 -0.0246737
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0245564
GARS1 glycyl-tRNA synthetase 1 -0.0244689
ARHGAP5 Rho GTPase activating protein 5 -0.0243627
RPS13 ribosomal protein S13 -0.0242731
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0242711
RPL23 ribosomal protein L23 -0.0240176
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0238267
CLIP2 CAP-GLY domain containing linker protein 2 -0.0237201
RPS23 ribosomal protein S23 -0.0236666
FBXL2 F-box and leucine-rich repeat protein 2 -0.0236102
FLNB filamin B, beta -0.0235461
PRAME preferentially expressed antigen in melanoma -0.0235054