Dimethyl fumarate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRD protein tyrosine phosphatase, receptor type, D 0.152835
VCL vinculin 0.13916
FMN1 formin 1 0.10922
MEIS2 Meis homeobox 2 0.104802
LSAMP limbic system-associated membrane protein 0.0967779
TLE4 transducin-like enhancer of split 4 0.0902165
NALF1 NALCN channel auxiliary factor 1 0.0748389
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0732419
TRIB2 tribbles pseudokinase 2 0.072999
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0661026
SEPTIN9 septin 9 0.0639764
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0615786
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0597949
BCAS3 breast carcinoma amplified sequence 3 0.0594665
VMP1 vacuole membrane protein 1 0.0583591
PRKCA protein kinase C, alpha 0.0571682
DPH6 diphthamine biosynthesis 6 0.0568072
PSD3 pleckstrin and Sec7 domain containing 3 0.0550043
ZSWIM6 zinc finger, SWIM-type containing 6 0.0526597
DST dystonin 0.0525932
SLITRK6 SLIT and NTRK-like family, member 6 0.0524948
LINGO2 leucine rich repeat and Ig domain containing 2 0.0506315
SMYD3 SET and MYND domain containing 3 0.0494436
NRG1 neuregulin 1 0.0468489
EEF2 eukaryotic translation elongation factor 2 0.0443749
AMOTL1 angiomotin like 1 0.0443704
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0440807
HELZ helicase with zinc finger 0.0437066
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0433804
DSCAM Down syndrome cell adhesion molecule 0.0421864
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0402092
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0399661
ZMIZ1 zinc finger, MIZ-type containing 1 0.0393066
LPIN1 lipin 1 0.0389046
ANTXR1 anthrax toxin receptor 1 0.0387213
TCF12 transcription factor 12 0.0385594
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0379466
ITPRID2 ITPR interacting domain containing 2 0.0374589
MSI2 musashi RNA-binding protein 2 0.0370145
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0370128
SDK1 sidekick cell adhesion molecule 1 0.0367307
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0364836
KLHL13 kelch-like family member 13 0.0361095
RNF213 ring finger protein 213 0.0360388
HSPA8 heat shock 70kDa protein 8 0.0357277
CHD9 chromodomain helicase DNA binding protein 9 0.0356658
NCOR2 nuclear receptor corepressor 2 0.0355362
LPP LIM domain containing preferred translocation partner in lipoma 0.035262
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0349072
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0348926
FAM13A family with sequence similarity 13, member A 0.0345976
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0345188
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0344268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0342691
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0339974
NPAS2 neuronal PAS domain protein 2 0.0337658
THSD4 thrombospondin, type I, domain containing 4 0.0337032
PELI1 pellino E3 ubiquitin protein ligase 1 0.0333557
STK38L serine/threonine kinase 38 like 0.0330463
SETBP1 SET binding protein 1 0.0327873
RALYL RALY RNA binding protein-like 0.0327536
MYH9 myosin, heavy chain 9, non-muscle 0.0326881
UNC5C unc-5 homolog C (C. elegans) 0.0326578
FNDC3A fibronectin type III domain containing 3A 0.0325272
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0322966
POTEF POTE ankyrin domain family, member F 0.0322655
KDM4C lysine (K)-specific demethylase 4C 0.0321428
RAD51B RAD51 paralog B 0.0317854
HMBOX1 homeobox containing 1 0.0317458
TBC1D5 TBC1 domain family, member 5 0.03173
DNMBP dynamin binding protein 0.031563
KMT2C lysine (K)-specific methyltransferase 2C 0.03138
TPM1 tropomyosin 1 (alpha) 0.0313173
DUSP10 dual specificity phosphatase 10 0.0312696
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0312635
ZBTB20 zinc finger and BTB domain containing 20 0.0312312
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0311229
EFNA5 ephrin-A5 0.0302329
PTPRM protein tyrosine phosphatase, receptor type, M 0.0301615
NFE2L1 nuclear factor, erythroid 2-like 1 0.0299058
RPTOR regulatory associated protein of MTOR, complex 1 0.029292
SRRM2 serine/arginine repetitive matrix 2 0.0286403
RAB30 RAB30, member RAS oncogene family 0.028411
SYT1 synaptotagmin I 0.0277472
CEMIP2 cell migration inducing hyaluronidase 2 0.0274352
GSE1 Gse1 coiled-coil protein 0.0270522
RPS2 ribosomal protein S2 0.0268855
SLIT2 slit homolog 2 (Drosophila) 0.0268479
BBX bobby sox homolog (Drosophila) 0.0266312
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0265602
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0263747
GAB2 GRB2-associated binding protein 2 0.0263743
TPM4 tropomyosin 4 0.0261578
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0261475
PLPP1 phospholipid phosphatase 1 0.0258694
PTEN phosphatase and tensin homolog 0.0258129
APP amyloid beta (A4) precursor protein 0.0257713
MED13L mediator complex subunit 13-like 0.0257385
TENT5A terminal nucleotidyltransferase 5A 0.0253216
ATXN1 ataxin 1 0.0252198

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.154069
PTMA prothymosin, alpha -0.118515
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.117356
AKAP12 A kinase (PRKA) anchor protein 12 -0.10043
RPL23 ribosomal protein L23 -0.0608429
RPL35A ribosomal protein L35a -0.0586214
VIM vimentin -0.0573846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0514001
TPT1 tumor protein, translationally-controlled 1 -0.0470186
RPLP1 ribosomal protein, large, P1 -0.0463783
B2M beta-2-microglobulin -0.046339
CEMIP cell migration inducing protein, hyaluronan binding -0.0457244
RPS24 ribosomal protein S24 -0.0437142
TMSB10 thymosin beta 10 -0.0432783
IER3 immediate early response 3 -0.0425143
GARS1 glycyl-tRNA synthetase 1 -0.0414153
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0407559
RPL34 ribosomal protein L34 -0.0406777
LIMCH1 LIM and calponin homology domains 1 -0.0401004
EIF1 eukaryotic translation initiation factor 1 -0.0395013
RPL38 ribosomal protein L38 -0.0377185
FTL ferritin, light polypeptide -0.0366536
RPL12 ribosomal protein L12 -0.0365398
STC1 stanniocalcin 1 -0.0354356
COL3A1 collagen, type III, alpha 1 -0.0337939
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0326092
KDM3A lysine (K)-specific demethylase 3A -0.0320755
NAMPT nicotinamide phosphoribosyltransferase -0.0307955
NAP1L1 nucleosome assembly protein 1-like 1 -0.03052
RPL19 ribosomal protein L19 -0.0301776
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0286645
RPL32 ribosomal protein L32 -0.028151
RPL31 ribosomal protein L31 -0.0276251
CCND1 cyclin D1 -0.0260476
AFF3 AF4/FMR2 family, member 3 -0.0247333
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0245846
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0244974
MARCHF6 membrane associated ring-CH-type finger 6 -0.0243591
CCDC47 coiled-coil domain containing 47 -0.0243535
WDR45B WD repeat domain 45B -0.0241506
RTN4 reticulon 4 -0.0240232
LMNA lamin A/C -0.0238793
IARS1 isoleucyl-tRNA synthetase 1 -0.0236234
LMAN1 lectin, mannose-binding, 1 -0.0232677
RSL1D1 ribosomal L1 domain containing 1 -0.022845
RAB6A RAB6A, member RAS oncogene family -0.0227824
RPS27A ribosomal protein S27a -0.0225091
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0223987
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0218745
CALR calreticulin -0.0216196
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.021427
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0213481
S100A6 S100 calcium binding protein A6 -0.0212359
RPS23 ribosomal protein S23 -0.0211992
RPS19 ribosomal protein S19 -0.0206978
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0205775
RPL36A ribosomal protein L36a -0.0205425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0205092
USP3 ubiquitin specific peptidase 3 -0.0204436
GDF15 growth differentiation factor 15 -0.0203875
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0202937
SCG2 secretogranin II -0.020033
CLINT1 clathrin interactor 1 -0.0199284
RPS3 ribosomal protein S3 -0.0196948
RRBP1 ribosome binding protein 1 -0.019585
NPEPPS aminopeptidase puromycin sensitive -0.0195727
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0194353
VDAC1 voltage-dependent anion channel 1 -0.0194086
RPS5 ribosomal protein S5 -0.0193704
RPL36 ribosomal protein L36 -0.0193683
AFF4 AF4/FMR2 family, member 4 -0.0192893
GPC5 glypican 5 -0.0192683
PDIA6 protein disulfide isomerase family A, member 6 -0.0191839
RAI14 retinoic acid induced 14 -0.0191217
AHNAK AHNAK nucleoprotein -0.019093
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0189885
WSB1 WD repeat and SOCS box containing 1 -0.0188094
ZC3H15 zinc finger CCCH-type containing 15 -0.0185566
H3-3B H3.3 histone B -0.0184272
OGA O-GlcNAcase -0.0183791
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0181152
KPNB1 karyopherin (importin) beta 1 -0.0181055
RHOBTB3 Rho-related BTB domain containing 3 -0.0179574
NCAM2 neural cell adhesion molecule 2 -0.0174684
RANBP17 RAN binding protein 17 -0.0174609
NOP58 NOP58 ribonucleoprotein -0.0174067
UBE2B ubiquitin-conjugating enzyme E2B -0.0173333
AKAP10 A kinase (PRKA) anchor protein 10 -0.0172832
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0171969
RPLP2 ribosomal protein, large, P2 -0.0171032
IGFBP4 insulin-like growth factor binding protein 4 -0.0170787
RPS6 ribosomal protein S6 -0.0170787
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0170397
PRR11 proline rich 11 -0.0169404
RPL18 ribosomal protein L18 -0.0167294
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0166687
FAM162A family with sequence similarity 162, member A -0.0166145
ANXA2 annexin A2 -0.0165104
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0164744
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0164348