Dimethyl fumarate_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.248631
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.101018
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0980831
SEPTIN9 septin 9 0.0756056
TRIO trio Rho guanine nucleotide exchange factor 0.060824
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0540476
FNDC3B fibronectin type III domain containing 3B 0.0505061
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0478837
MCL1 myeloid cell leukemia 1 0.0472392
NAV2 neuron navigator 2 0.0460358
FLNA filamin A, alpha 0.0410167
DUSP6 dual specificity phosphatase 6 0.0400862
MYH9 myosin, heavy chain 9, non-muscle 0.04
PRELID2 PRELI domain containing 2 0.0396171
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0391771
MSN moesin 0.037795
CD44 CD44 molecule (Indian blood group) 0.0367006
PCBP3 poly(rC) binding protein 3 0.036304
GOLGA4 golgin A4 0.0359762
SHB Src homology 2 domain containing adaptor protein B 0.0346005
FNIP1 folliculin interacting protein 1 0.0341689
SMAD3 SMAD family member 3 0.0333613
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0323499
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0317967
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0317842
CD109 CD109 molecule 0.031159
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0311095
LOC112694756 uncharaterized LOC112694756 0.0306942
SBF2 SET binding factor 2 0.0305387
NGLY1 N-glycanase 1 0.0293738
ANKRD12 ankyrin repeat domain 12 0.0281276
RB1CC1 RB1-inducible coiled-coil 1 0.027233
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0271312
COL6A2 collagen, type VI, alpha 2 0.0262865
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0262026
OGA O-GlcNAcase 0.0258767
TMF1 TATA element modulatory factor 1 0.0255417
BACE2 beta-site APP-cleaving enzyme 2 0.0255252
FLNB filamin B, beta 0.0247165
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0243919
YEATS2 YEATS domain containing 2 0.0243024
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.024047
TGFBI transforming growth factor, beta-induced, 68kDa 0.0234517
EPN2 epsin 2 0.023411
CDK19 cyclin-dependent kinase 19 0.022519
PLEC plectin 0.0220011
ESYT2 extended synaptotagmin-like protein 2 0.0216533
TNS1 tensin 1 0.0216349
RTN4 reticulon 4 0.021478
DNMBP dynamin binding protein 0.0209141
SP3 Sp3 transcription factor 0.0208061
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0204871
PDE10A phosphodiesterase 10A 0.0203481
AGRN agrin 0.0201161
CAMTA1 calmodulin binding transcription activator 1 0.0198628
JARID2 jumonji, AT rich interactive domain 2 0.0198316
CENPF centromere protein F, 350/400kDa 0.0197953
AKAP9 A kinase (PRKA) anchor protein 9 0.0196765
GOLGB1 golgin B1 0.0195679
SRRM2 serine/arginine repetitive matrix 2 0.0192516
GRB10 growth factor receptor-bound protein 10 0.0192038
MIS18BP1 MIS18 binding protein 1 0.0191468
SPRED1 sprouty-related, EVH1 domain containing 1 0.0190558
LPIN2 lipin 2 0.0189589
ANGPTL4 angiopoietin-like 4 0.0188588
FAM13A family with sequence similarity 13, member A 0.0188077
EFNA5 ephrin-A5 0.0187595
DOT1L DOT1-like histone H3K79 methyltransferase 0.0185439
FAM219A family with sequence similarity 219, member A 0.0184951
ENO1 enolase 1, (alpha) 0.0182129
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0181675
SYAP1 synapse associated protein 1 0.0181375
TXNIP thioredoxin interacting protein 0.0181276
CEP192 centrosomal protein 192kDa 0.0180701
SDC4 syndecan 4 0.0178861
FAM114A1 family with sequence similarity 114, member A1 0.0173893
ARFGEF3 ARFGEF family member 3 0.0173676
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.017357
RND3 Rho family GTPase 3 0.0170831
PRRC2A proline-rich coiled-coil 2A 0.0170153
TBC1D23 TBC1 domain family, member 23 0.016926
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0167981
ACTN1 actinin, alpha 1 0.0166658
METTL15 methyltransferase like 15 0.0166196
DSCAM Down syndrome cell adhesion molecule 0.0165245
RNF220 ring finger protein 220 0.0163941
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0163555
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0163461
POM121 POM121 transmembrane nucleoporin 0.0162221
KDM2A lysine (K)-specific demethylase 2A 0.0161594
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0160881
TAS2R14 taste receptor, type 2, member 14 0.0158907
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0158668
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0158322
SEC23A Sec23 homolog A (S. cerevisiae) 0.0157945
MARCHF7 membrane associated ring-CH-type finger 7 0.0157538
RUNX1 runt-related transcription factor 1 0.0156117
PTPRM protein tyrosine phosphatase, receptor type, M 0.0155785
BBX bobby sox homolog (Drosophila) 0.0155555
DDIT4 DNA-damage-inducible transcript 4 0.0155057

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.233785
TMSB10 thymosin beta 10 -0.167921
IGF2 insulin-like growth factor 2 -0.130081
MYO10 myosin X -0.0919477
EXT1 exostosin glycosyltransferase 1 -0.0904207
FN1 fibronectin 1 -0.0851827
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0831427
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0815384
HMGA2 high mobility group AT-hook 2 -0.0798959
RAI14 retinoic acid induced 14 -0.0792121
COL5A1 collagen, type V, alpha 1 -0.076385
AHNAK AHNAK nucleoprotein -0.0731851
ASPH aspartate beta-hydroxylase -0.0688416
CDH13 cadherin 13 -0.0655161
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0644753
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0643274
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0615971
PTMA prothymosin, alpha -0.0569468
CLMP CXADR-like membrane protein -0.0519967
NALF1 NALCN channel auxiliary factor 1 -0.0490341
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0423918
RPLP1 ribosomal protein, large, P1 -0.0421874
IER3 immediate early response 3 -0.0414437
CCND1 cyclin D1 -0.0397273
MAML3 mastermind-like 3 (Drosophila) -0.0394454
CALR calreticulin -0.0392095
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0389038
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0386407
FTL ferritin, light polypeptide -0.0369246
TPT1 tumor protein, translationally-controlled 1 -0.0362246
INHBA inhibin, beta A -0.0359239
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.035845
IGFBP3 insulin-like growth factor binding protein 3 -0.0350348
PRSS23 protease, serine, 23 -0.0350031
NDRG1 N-myc downstream regulated 1 -0.0345041
TPM1 tropomyosin 1 (alpha) -0.0335162
ANXA2 annexin A2 -0.0332661
PGK1 phosphoglycerate kinase 1 -0.0331646
TFRC transferrin receptor -0.0325204
WSB1 WD repeat and SOCS box containing 1 -0.0309286
PKM pyruvate kinase, muscle -0.0306017
DST dystonin -0.0304759
S100A10 S100 calcium binding protein A10 -0.0301735
RPL35A ribosomal protein L35a -0.0297587
RYBP RING1 and YY1 binding protein -0.0297134
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0295827
TPM4 tropomyosin 4 -0.0284589
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0273812
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.02684
USP3 ubiquitin specific peptidase 3 -0.0268208
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.026367
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0263617
PDIA3 protein disulfide isomerase family A, member 3 -0.0263412
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0261483
QKI QKI, KH domain containing, RNA binding -0.0260102
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0256971
COL1A1 collagen, type I, alpha 1 -0.0252308
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0249734
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0247602
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0246416
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0245142
BICD1 bicaudal D homolog 1 (Drosophila) -0.0243161
ACTG1 actin gamma 1 -0.0243025
RAB31 RAB31, member RAS oncogene family -0.0242712
CDK6 cyclin-dependent kinase 6 -0.0242237
F3 coagulation factor III (thromboplastin, tissue factor) -0.0241523
RPS24 ribosomal protein S24 -0.0241368
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0235582
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0231078
ARHGAP22 Rho GTPase activating protein 22 -0.0229487
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0229327
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.022917
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0227563
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0226787
FAM162A family with sequence similarity 162, member A -0.0226657
PTPRG protein tyrosine phosphatase, receptor type, G -0.022314
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0220156
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0219603
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0217583
ZFAND3 zinc finger, AN1-type domain 3 -0.0215194
FOXP1 forkhead box P1 -0.021308
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0213026
LAMB3 laminin, beta 3 -0.0212284
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0211504
CUX1 cut-like homeobox 1 -0.0208803
TCF12 transcription factor 12 -0.0207343
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0206767
DNER delta/notch-like EGF repeat containing -0.0206494
UGCG UDP-glucose ceramide glucosyltransferase -0.0204669
RNF145 ring finger protein 145 -0.0204293
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0203781
AKAP12 A kinase (PRKA) anchor protein 12 -0.0199792
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0198288
ZBTB20 zinc finger and BTB domain containing 20 -0.0197957
KPNB1 karyopherin (importin) beta 1 -0.0197732
DIAPH2 diaphanous-related formin 2 -0.01971
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0196512
NAMPT nicotinamide phosphoribosyltransferase -0.019603
LOX lysyl oxidase -0.0190434
FBXO11 F-box protein 11 -0.0189455