Dimethyl fumarate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.185229
MTSS1 metastasis suppressor 1 0.126717
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.125452
CEMIP cell migration inducing protein, hyaluronan binding 0.124805
FOXO1 forkhead box O1 0.103912
DOCK5 dedicator of cytokinesis 5 0.10186
BCL2L1 BCL2-like 1 0.0967657
LAMA5 laminin, alpha 5 0.087553
TGM2 transglutaminase 2 0.0840454
MYH9 myosin, heavy chain 9, non-muscle 0.083796
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0758004
RIN2 Ras and Rab interactor 2 0.073091
EZR ezrin 0.0720102
APLP2 amyloid beta (A4) precursor-like protein 2 0.071281
PLEC plectin 0.0704573
CD44 CD44 molecule (Indian blood group) 0.0690561
H1-0 H1.0 linker histone 0.0689218
MEF2A myocyte enhancer factor 2A 0.0653527
ESYT2 extended synaptotagmin-like protein 2 0.0632326
MYOF myoferlin 0.0613897
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0602374
SMAD3 SMAD family member 3 0.0591894
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0590653
PODXL podocalyxin-like 0.0590119
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0575248
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0566802
FLNA filamin A, alpha 0.056091
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0560602
ASPH aspartate beta-hydroxylase 0.0554865
EPHA2 EPH receptor A2 0.0553291
CALU calumenin 0.0551876
ENO1 enolase 1, (alpha) 0.0548046
NEK7 NIMA-related kinase 7 0.0541469
PRELID2 PRELI domain containing 2 0.0541392
LOC112694756 uncharaterized LOC112694756 0.0541067
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0501613
MSN moesin 0.0501332
NRG1 neuregulin 1 0.048389
BLCAP bladder cancer associated protein 0.0480402
PLAT plasminogen activator, tissue 0.047802
PDLIM1 PDZ and LIM domain 1 0.04736
EFHD2 EF-hand domain family, member D2 0.0473377
METTL15 methyltransferase like 15 0.0468248
BCAR3 breast cancer anti-estrogen resistance 3 0.0463747
ITGA6 integrin, alpha 6 0.0463116
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0455961
ANKRD33B ankyrin repeat domain 33B 0.0454685
OSMR oncostatin M receptor 0.0449084
CD59 CD59 molecule, complement regulatory protein 0.0445736
MBNL1 muscleblind-like splicing regulator 1 0.0444079
NCOR2 nuclear receptor corepressor 2 0.0438533
CMIP c-Maf inducing protein 0.0426756
JAG1 jagged 1 0.0419512
ANXA11 annexin A11 0.0412897
TSC22D1 TSC22 domain family, member 1 0.0410073
EMP1 epithelial membrane protein 1 0.0394556
KTN1 kinectin 1 (kinesin receptor) 0.0394064
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0392016
NAMPT nicotinamide phosphoribosyltransferase 0.0386066
FNDC3B fibronectin type III domain containing 3B 0.0381826
ANXA2 annexin A2 0.0380662
ARHGAP21 Rho GTPase activating protein 21 0.0375478
CLU clusterin 0.036877
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0368339
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0362389
FNIP1 folliculin interacting protein 1 0.036218
LUZP1 leucine zipper protein 1 0.0359691
NF1 neurofibromin 1 0.0359037
NIBAN2 niban apoptosis regulator 2 0.0355809
SEPTIN9 septin 9 0.0354855
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0354097
TPM3 tropomyosin 3 0.03504
ANO6 anoctamin 6 0.0350076
BARX2 BARX homeobox 2 0.0348239
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0347579
NRIP1 nuclear receptor interacting protein 1 0.0341321
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0332044
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.032872
APP amyloid beta (A4) precursor protein 0.0327757
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0318913
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0312339
COPA coatomer protein complex, subunit alpha 0.0312267
RPL3 ribosomal protein L3 0.031077
TNS4 tensin 4 0.0310346
AKAP9 A kinase (PRKA) anchor protein 9 0.030896
SOX13 SRY (sex determining region Y)-box 13 0.0308062
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0305477
FAM114A1 family with sequence similarity 114, member A1 0.0305224
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0304955
KIF16B kinesin family member 16B 0.0304683
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0304398
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0302464
MBNL2 muscleblind-like splicing regulator 2 0.0300308
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0298918
ARGLU1 arginine and glutamate rich 1 0.0294037
SH3PXD2A SH3 and PX domains 2A 0.0291461
SLC45A4 solute carrier family 45, member 4 0.0290235
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.028949
RICTOR RPTOR independent companion of MTOR, complex 2 0.0288166
KIAA1217 KIAA1217 0.0287275

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.307914
TIMP3 TIMP metallopeptidase inhibitor 3 -0.169412
LMO7 LIM domain 7 -0.105066
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103327
ABI3BP ABI family, member 3 (NESH) binding protein -0.0778516
ALCAM activated leukocyte cell adhesion molecule -0.0737702
PDLIM5 PDZ and LIM domain 5 -0.0684412
PTMA prothymosin, alpha -0.059362
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0581611
INTS6 integrator complex subunit 6 -0.0561065
PDE4D phosphodiesterase 4D, cAMP-specific -0.0553503
DPYD dihydropyrimidine dehydrogenase -0.0493975
TPT1 tumor protein, translationally-controlled 1 -0.0487432
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0480521
SAMD9 sterile alpha motif domain containing 9 -0.0478448
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0443625
RABGAP1L RAB GTPase activating protein 1-like -0.0431061
TMSB10 thymosin beta 10 -0.043014
RPS24 ribosomal protein S24 -0.0407623
ZMYND8 zinc finger, MYND-type containing 8 -0.0398592
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0379848
PLS3 plastin 3 -0.0377687
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0377442
SULF1 sulfatase 1 -0.037099
RAB7A RAB7A, member RAS oncogene family -0.0366918
STC1 stanniocalcin 1 -0.0366005
RIGI RNA sensor RIG-I -0.0362478
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0346539
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.03362
KLF5 Kruppel-like factor 5 (intestinal) -0.0317497
RPL34 ribosomal protein L34 -0.0312939
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0308281
AHNAK AHNAK nucleoprotein -0.0306951
S100A10 S100 calcium binding protein A10 -0.0304442
GNAS GNAS complex locus -0.0298885
FBXO11 F-box protein 11 -0.0296845
HMGA2 high mobility group AT-hook 2 -0.0296329
PRSS23 protease, serine, 23 -0.0294203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0293766
RPLP1 ribosomal protein, large, P1 -0.0291882
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0289708
IGF2 insulin-like growth factor 2 -0.0281375
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0279295
S100A11 S100 calcium binding protein A11 -0.0276517
B2M beta-2-microglobulin -0.0274349
UTRN utrophin -0.0270017
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0259621
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0258759
F3 coagulation factor III (thromboplastin, tissue factor) -0.0255476
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0253993
AFG2A AFG2 AAA ATPase homolog A -0.0249275
SLC35F3 solute carrier family 35, member F3 -0.0249137
CRACDL CRACD like -0.024047
NAP1L1 nucleosome assembly protein 1-like 1 -0.023915
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0232039
THBD thrombomodulin -0.0231531
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0229549
TMSB4X thymosin beta 4, X-linked -0.0228567
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0227597
RPS23 ribosomal protein S23 -0.0222692
RGS4 regulator of G-protein signaling 4 -0.0219968
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0217568
FTL ferritin, light polypeptide -0.0216836
CDK6 cyclin-dependent kinase 6 -0.0216051
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0213461
LARS1 leucyl-tRNA synthetase 1 -0.0212105
FN1 fibronectin 1 -0.021159
RPS25 ribosomal protein S25 -0.0211483
DENND1A DENN/MADD domain containing 1A -0.0210576
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0209663
DSG2 desmoglein 2 -0.0209321
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0208527
FRMD4B FERM domain containing 4B -0.0207333
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0205261
RPS21 ribosomal protein S21 -0.0204243
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0203627
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0203553
LAMC2 laminin, gamma 2 -0.0199537
CTBP2 C-terminal binding protein 2 -0.0197729
RPS19 ribosomal protein S19 -0.0197028
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0194607
RPL35A ribosomal protein L35a -0.019432
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.019414
KISS1 KiSS-1 metastasis-suppressor -0.0192725
CALR calreticulin -0.0190474
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0190292
WSB1 WD repeat and SOCS box containing 1 -0.0188748
WNT2B wingless-type MMTV integration site family, member 2B -0.0188415
IFITM1 interferon induced transmembrane protein 1 -0.018684
SOD2 superoxide dismutase 2, mitochondrial -0.0186632
CSTB cystatin B (stefin B) -0.018527
CALB1 calbindin 1, 28kDa -0.0184907
RPLP2 ribosomal protein, large, P2 -0.0181793
ERBIN erbb2 interacting protein -0.0180226
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.018001
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0179159
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.017908
PCDH9 protocadherin 9 -0.0178398
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0178035
MTDH metadherin -0.0177911